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- W4282936341 abstract "Intracranial tumors rarely accompany Down syndrome. Although germ cell tumor and glioma have been reported in Down syndrome, primary central nervous system lymphoma (PCNSL) has not been reported in Down syndrome. We report our experience with a patient with Down syndrome in whom PCNSL was diagnosed. The patient, a 48-year-old man with a diagnosis of Down syndrome, had no history of malignant tumors. The patient visited the hospital with complaints of left hemiparesis and gait disturbance. A thorough examination revealed the brain tumors, and tumor biopsy confirmed the diagnosis of PCNSL. The final pathological diagnosis was diffuse large B-cell lymphoma of the central nervous system. Chemotherapy with rituximab, methotrexate, procarbazine, and vincristine was administered, and whole-brain irradiation was planned in conjunction with chemotherapy. It is unclear whether the chromosomal abnormalities of Down syndrome were involved in the development of PCNSL or not. Further molecular biological analysis may clarify the mechanism of the combination of Down syndrome and PCNSL." @default.
- W4282936341 created "2022-06-16" @default.
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- W4282936341 date "2023-08-25" @default.
- W4282936341 modified "2023-09-25" @default.
- W4282936341 title "Primary Central Nervous System Lymphoma in a Patient with Down Syndrome" @default.
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- W4282936341 doi "https://doi.org/10.1272/jnms.jnms.2023_90-502" @default.
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