Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282936679> ?p ?o ?g. }
- W4282936679 endingPage "C460" @default.
- W4282936679 startingPage "C439" @default.
- W4282936679 abstract "G protein-gated inwardly rectifying K + (GIRK/Kir3) channels exert a critical inhibitory influence on neurons. Neuronal GIRK channels mediate the G protein-dependent, direct/postsynaptic inhibitory effect of many neurotransmitters including γ-aminobutyric acid (GABA), serotonin, dopamine, adenosine, somatostatin, and enkephalin. In addition to their complex regulation by G proteins, neuronal GIRK channel activity is sensitive to phosphatidylinositol 4,5-bisphosphate (PIP 2 ), phosphorylation, regulator of G protein signaling (RGS) proteins, intracellular Na + and Ca 2+ , and cholesterol. The application of genetic and viral manipulations in rodent models, together with recent progress in the development of GIRK channel modulators, has increased our understanding of the physiological and behavioral impact of neuronal GIRK channels. Work in rodent models has also revealed that neuronal GIRK channel activity is modified, transiently or persistently, by various stimuli including exposure drugs of abuse, changes in neuronal activity patterns, and aversive experience. A growing body of preclinical and clinical evidence suggests that dysregulation of GIRK channel activity contributes to neurological diseases and disorders. The primary goals of this review are to highlight fundamental principles of neuronal GIRK channel biology, mechanisms of GIRK channel regulation and plasticity, the nascent landscape of GIRK channel pharmacology, and the potential relevance of GIRK channels to the pathophysiology and treatment of neurological diseases and disorders." @default.
- W4282936679 created "2022-06-16" @default.
- W4282936679 creator A5054992094 @default.
- W4282936679 creator A5082179634 @default.
- W4282936679 creator A5091599894 @default.
- W4282936679 date "2022-08-01" @default.
- W4282936679 modified "2023-10-15" @default.
- W4282936679 title "Neuronal G protein-gated K<sup>+</sup> channels" @default.
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