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• W4282936700 abstract "Malignant mixed mesodermal sarcomas (myxoid leiomyosarcomas - MLMS) are a rare form of uterine cancer developed from the smooth muscles of the uterus. It usually affects women in the postmenopausal period and has an aggressive character with an unfavorable evolution and prognosis. This paper presents a case where MLMS was postoperatively confirmed with the aid of the histopathological (HP) examination coupled with specific immunolabeling techniques. In addition, we reviewed modern literature to compare our results. Clinically, patients may present with a pelvic tumor, vaginal bleeding, or abdominal pressure. Imagistic investigations, such as pelvic ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET)-CT may support the diagnosis. Nevertheless, solely the HP examination establishes it. Macroscopically, MLMS is soft and gelatinous, unlike the conventional rigid and spiral leiomyoma appearance. Furthermore, the infiltrative, irregular tumor margin is characteristic of MLMS. From a microscopic point of view, the following are present: tumor cell necrosis, nuclear pleomorphism, and variable mitotic activity. With classical Hematoxylin-Eosin (HE) staining, myometrium presents a leiomyomatous structure and multiple nodular formations with the aspect of malignant tumor proliferation, most likely mesenchymal. We used multiple special immunolabeling techniques. Thus, we observed the intense reactivity of the cells to the anti-vimentin antibody, which immunolabeled type III intermediate filament (IF) protein expressed in mesenchymal cells, thus demonstrating tumor mesenchymal affiliation. Smooth cell positivity for alpha-smooth muscle actin (α-SMA) demonstrates that the tumor is present in its whole myometrial structure. Tumor cells also underwent mutations involving the p53 tumor suppressor gene demonstrated by the number of tumoral cells in division immunolabeled with anti-Ki67 proliferation antibody. Tumor development was demonstrated by protein activation of cyclin-dependent kinase (CDK) and the presence of c-Kit-bound hematopoietic stem cells, immunolabeled with the anti-cluster of differentiation 117 (anti-CD117) antibodies. The anti-desmin antibody demonstrates, along with α-SMA, the involvement of myocytes in the tumoral process. The following microscopic characteristics laid the foundation for the diagnosis of MLMS: irregular myometrial invasion, rare mitosis on high-power fields (HPFs), cell pleomorphism, predominant myxoid component that gave a hypocellular appearance, the matrix rich in proteoglycans and glycosaminoglycans, especially hyaluronic acid." @default.
• W4282936700 created "2022-06-16" @default.
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• W4282936700 date "2022-06-07" @default.
• W4282936700 modified "2023-10-01" @default.
• W4282936700 title "Uterine myxoid leiomyosarcoma – a rare malignant tumor: the role of complex morphopathological assay. Review and case presentation" @default.
• W4282936700 cites W133038788 @default.
• W4282936700 cites W1480357432 @default.
• W4282936700 cites W1519598930 @default.
• W4282936700 cites W1560490367 @default.
• W4282936700 cites W1586414137 @default.
• W4282936700 cites W1771837493 @default.
• W4282936700 cites W1840967916 @default.
• W4282936700 cites W1909357483 @default.
• W4282936700 cites W1923636344 @default.
• W4282936700 cites W1930527465 @default.
• W4282936700 cites W1978250292 @default.
• W4282936700 cites W1983500753 @default.
• W4282936700 cites W1983626262 @default.
• W4282936700 cites W1983789135 @default.
• W4282936700 cites W1985888795 @default.
• W4282936700 cites W1988111529 @default.
• W4282936700 cites W1990238686 @default.
• W4282936700 cites W1995366332 @default.
• W4282936700 cites W1996113298 @default.
• W4282936700 cites W1996319104 @default.
• W4282936700 cites W1997073961 @default.
• W4282936700 cites W2003175034 @default.
• W4282936700 cites W2004716010 @default.
• W4282936700 cites W2006662348 @default.
• W4282936700 cites W2007529700 @default.
• W4282936700 cites W2017846490 @default.
• W4282936700 cites W2020619763 @default.
• W4282936700 cites W2023189554 @default.
• W4282936700 cites W2024641771 @default.
• W4282936700 cites W2025543561 @default.
• W4282936700 cites W2027584970 @default.
• W4282936700 cites W2029810285 @default.
• W4282936700 cites W2031391627 @default.
• W4282936700 cites W2034036012 @default.
• W4282936700 cites W2036762185 @default.
• W4282936700 cites W2043654243 @default.
• W4282936700 cites W2052897249 @default.
• W4282936700 cites W2055332455 @default.
• W4282936700 cites W2055524139 @default.
• W4282936700 cites W2058304326 @default.
• W4282936700 cites W2058742695 @default.
• W4282936700 cites W2058766318 @default.
• W4282936700 cites W2059119097 @default.
• W4282936700 cites W2073497172 @default.
• W4282936700 cites W2074865334 @default.
• W4282936700 cites W2080239906 @default.
• W4282936700 cites W2080860848 @default.
• W4282936700 cites W2083135587 @default.
• W4282936700 cites W2085575652 @default.
• W4282936700 cites W2092279593 @default.
• W4282936700 cites W2094818680 @default.
• W4282936700 cites W2100164970 @default.
• W4282936700 cites W2102942479 @default.
• W4282936700 cites W2108401821 @default.
• W4282936700 cites W2110289140 @default.
• W4282936700 cites W2131464730 @default.
• W4282936700 cites W2141087172 @default.
• W4282936700 cites W2141532348 @default.
• W4282936700 cites W2145431452 @default.
• W4282936700 cites W2149142217 @default.
• W4282936700 cites W2157059052 @default.
• W4282936700 cites W2158770127 @default.
• W4282936700 cites W2162751861 @default.
• W4282936700 cites W2165422610 @default.
• W4282936700 cites W2166535515 @default.
• W4282936700 cites W2331809926 @default.
• W4282936700 cites W2337929499 @default.
• W4282936700 cites W2380751451 @default.
• W4282936700 cites W2400373317 @default.
• W4282936700 cites W2409071178 @default.
• W4282936700 cites W2415944286 @default.
• W4282936700 cites W2428002933 @default.
• W4282936700 cites W2467426025 @default.
• W4282936700 cites W2472456336 @default.
• W4282936700 cites W2508912450 @default.
• W4282936700 cites W2529162428 @default.
• W4282936700 cites W2560022845 @default.
• W4282936700 cites W2564089663 @default.
• W4282936700 cites W2745001222 @default.
• W4282936700 cites W2790811691 @default.
• W4282936700 cites W2797908775 @default.

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