Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282937523> ?p ?o ?g. }
- W4282937523 abstract "Tumor-associated antigen mucin 1 (MUC1) is highly expressed in colorectal cancer and is positively correlated with advanced stage at diagnosis and poor patient outcomes. The combination of irinotecan and capecitabine is standard chemotherapy for metastatic colorectal cancer and is known as XELIRI or CAPIRI, which significantly prolongs the progression-free survival and overall survival of colorectal cancer patients compared to a single drug alone. We previously reported that peanut agglutinin (PNA)-conjugated liposomes showed enhanced drug delivery efficiency to MUC1-positive liver cancer cells. In this study, we prepared irinotecan hydrochloride (IRI) and capecitabine (CAP)-coloaded liposomes modified by peanut agglutinin (IRI/CAP-PNA-Lips) to target MUC1-positive colorectal cancer. The results showed that IRI/CAP-PNA-Lips showed an enhanced ability to target MUC1-positive colorectal cancer cells compared to unmodified liposomes. Treatment with IRI/CAP-PNA-Lips also increased the proportion of apoptotic cells and inhibited the proliferation of colorectal cancer cells. The targeting specificity for tumor cells and the antitumor effects of PNA-modified liposomes were significantly increased in tumor-bearing mice with no severe cytotoxicity to normal tissues. These results suggest that PNA-modified liposomes could provide a new delivery strategy for the synergistic treatment of colorectal cancer with clinical chemotherapeutic agents." @default.
- W4282937523 created "2022-06-16" @default.
- W4282937523 creator A5010260063 @default.
- W4282937523 creator A5012271804 @default.
- W4282937523 creator A5016613742 @default.
- W4282937523 creator A5023918475 @default.
- W4282937523 creator A5027833059 @default.
- W4282937523 creator A5028481015 @default.
- W4282937523 creator A5036752617 @default.
- W4282937523 creator A5044005435 @default.
- W4282937523 creator A5051342685 @default.
- W4282937523 creator A5054533567 @default.
- W4282937523 creator A5061646717 @default.
- W4282937523 creator A5068286917 @default.
- W4282937523 creator A5068318066 @default.
- W4282937523 creator A5084537817 @default.
- W4282937523 creator A5086883094 @default.
- W4282937523 date "2022-06-15" @default.
- W4282937523 modified "2023-09-27" @default.
- W4282937523 title "PNA-Modified Liposomes Improve the Delivery Efficacy of CAPIRI for the Synergistic Treatment of Colorectal Cancer" @default.
- W4282937523 cites W1129784260 @default.
- W4282937523 cites W1199355021 @default.
- W4282937523 cites W1535876276 @default.
- W4282937523 cites W1978739865 @default.
- W4282937523 cites W1989230986 @default.
- W4282937523 cites W1992553088 @default.
- W4282937523 cites W2010001534 @default.
- W4282937523 cites W2030087487 @default.
- W4282937523 cites W2035345231 @default.
- W4282937523 cites W2052441727 @default.
- W4282937523 cites W2076226743 @default.
- W4282937523 cites W2080926921 @default.
- W4282937523 cites W2087675944 @default.
- W4282937523 cites W2117142296 @default.
- W4282937523 cites W2123237110 @default.
- W4282937523 cites W2168739610 @default.
- W4282937523 cites W2250377728 @default.
- W4282937523 cites W2289752352 @default.
- W4282937523 cites W2418260427 @default.
- W4282937523 cites W2514106337 @default.
- W4282937523 cites W2532272712 @default.
- W4282937523 cites W2603461243 @default.
- W4282937523 cites W2604987087 @default.
- W4282937523 cites W2605172092 @default.
- W4282937523 cites W2619324674 @default.
- W4282937523 cites W2732625227 @default.
- W4282937523 cites W2737268492 @default.
- W4282937523 cites W2740207635 @default.
- W4282937523 cites W2770147253 @default.
- W4282937523 cites W2783686102 @default.
- W4282937523 cites W2790768119 @default.
- W4282937523 cites W2889029945 @default.
- W4282937523 cites W2903377348 @default.
- W4282937523 cites W2905006914 @default.
- W4282937523 cites W2906239489 @default.
- W4282937523 cites W2906607297 @default.
- W4282937523 cites W2908738395 @default.
- W4282937523 cites W2910346583 @default.
- W4282937523 cites W2911425042 @default.
- W4282937523 cites W2914977264 @default.
- W4282937523 cites W2915422452 @default.
- W4282937523 cites W2938630570 @default.
- W4282937523 cites W2962835043 @default.
- W4282937523 cites W2968818285 @default.
- W4282937523 cites W2972284379 @default.
- W4282937523 cites W2982701461 @default.
- W4282937523 cites W2984986820 @default.
- W4282937523 cites W2995919583 @default.
- W4282937523 cites W3014037184 @default.
- W4282937523 cites W3024311661 @default.
- W4282937523 cites W3034111719 @default.
- W4282937523 cites W3037291653 @default.
- W4282937523 cites W3041400665 @default.
- W4282937523 cites W3093306906 @default.
- W4282937523 cites W3093730945 @default.
- W4282937523 cites W3119707796 @default.
- W4282937523 cites W3128646645 @default.
- W4282937523 cites W3190179005 @default.
- W4282937523 doi "https://doi.org/10.3389/fphar.2022.893151" @default.
- W4282937523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35784721" @default.
- W4282937523 hasPublicationYear "2022" @default.
- W4282937523 type Work @default.
- W4282937523 citedByCount "2" @default.
- W4282937523 countsByYear W42829375232022 @default.
- W4282937523 countsByYear W42829375232023 @default.
- W4282937523 crossrefType "journal-article" @default.
- W4282937523 hasAuthorship W4282937523A5010260063 @default.
- W4282937523 hasAuthorship W4282937523A5012271804 @default.
- W4282937523 hasAuthorship W4282937523A5016613742 @default.
- W4282937523 hasAuthorship W4282937523A5023918475 @default.
- W4282937523 hasAuthorship W4282937523A5027833059 @default.
- W4282937523 hasAuthorship W4282937523A5028481015 @default.
- W4282937523 hasAuthorship W4282937523A5036752617 @default.
- W4282937523 hasAuthorship W4282937523A5044005435 @default.
- W4282937523 hasAuthorship W4282937523A5051342685 @default.
- W4282937523 hasAuthorship W4282937523A5054533567 @default.
- W4282937523 hasAuthorship W4282937523A5061646717 @default.
- W4282937523 hasAuthorship W4282937523A5068286917 @default.
- W4282937523 hasAuthorship W4282937523A5068318066 @default.
- W4282937523 hasAuthorship W4282937523A5084537817 @default.