FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282938106> ?p ?o ?g. }

• W4282938106 endingPage "1653" @default.
• W4282938106 startingPage "1644" @default.
• W4282938106 abstract "Genome-wide association studies in combination with single-cell genomic atlases can provide insights into the mechanisms of disease-causal genetic variation. However, identification of disease-relevant or trait-relevant cell types, states and trajectories is often hampered by sparsity and noise, particularly in the analysis of single-cell epigenomic data. To overcome these challenges, we present SCAVENGE, a computational algorithm that uses network propagation to map causal variants to their relevant cellular context at single-cell resolution. We demonstrate how SCAVENGE can help identify key biological mechanisms underlying human genetic variation, applying the method to blood traits at distinct stages of human hematopoiesis, to monocyte subsets that increase the risk for severe Coronavirus Disease 2019 (COVID-19) and to intermediate lymphocyte developmental states that predispose to acute leukemia. Our approach not only provides a framework for enabling variant-to-function insights at single-cell resolution but also suggests a more general strategy for maximizing the inferences that can be made using single-cell genomic data." @default.
• W4282938106 created "2022-06-16" @default.
• W4282938106 creator A5000074913 @default.
• W4282938106 creator A5026663934 @default.
• W4282938106 creator A5028716177 @default.
• W4282938106 creator A5040881212 @default.
• W4282938106 creator A5043076766 @default.
• W4282938106 creator A5047265349 @default.
• W4282938106 creator A5048046433 @default.
• W4282938106 creator A5050200171 @default.
• W4282938106 creator A5053877118 @default.
• W4282938106 creator A5059967860 @default.
• W4282938106 creator A5077513980 @default.
• W4282938106 date "2022-06-06" @default.
• W4282938106 modified "2023-10-05" @default.
• W4282938106 title "Variant to function mapping at single-cell resolution through network propagation" @default.
• W4282938106 cites W1492083415 @default.
• W4282938106 cites W1631320694 @default.
• W4282938106 cites W1844405070 @default.
• W4282938106 cites W1980860344 @default.
• W4282938106 cites W1984065010 @default.
• W4282938106 cites W1993287310 @default.
• W4282938106 cites W2003338662 @default.
• W4282938106 cites W2033151532 @default.
• W4282938106 cites W2056198580 @default.
• W4282938106 cites W2066636486 @default.
• W4282938106 cites W2090160477 @default.
• W4282938106 cites W2133299088 @default.
• W4282938106 cites W2151645052 @default.
• W4282938106 cites W2155449815 @default.
• W4282938106 cites W2171172082 @default.
• W4282938106 cites W2297080912 @default.
• W4282938106 cites W2297334215 @default.
• W4282938106 cites W2514448720 @default.
• W4282938106 cites W2550031966 @default.
• W4282938106 cites W2624021832 @default.
• W4282938106 cites W2750049634 @default.
• W4282938106 cites W2782225074 @default.
• W4282938106 cites W2794521141 @default.
• W4282938106 cites W2806225217 @default.
• W4282938106 cites W2844212995 @default.
• W4282938106 cites W2887694579 @default.
• W4282938106 cites W2889326414 @default.
• W4282938106 cites W2894662039 @default.
• W4282938106 cites W2920191405 @default.
• W4282938106 cites W2925075625 @default.
• W4282938106 cites W2951516098 @default.
• W4282938106 cites W2953047957 @default.
• W4282938106 cites W2965985232 @default.
• W4282938106 cites W2973326578 @default.
• W4282938106 cites W2977079874 @default.
• W4282938106 cites W2979464975 @default.
• W4282938106 cites W2984472267 @default.
• W4282938106 cites W2989061519 @default.
• W4282938106 cites W2991023348 @default.
• W4282938106 cites W2991283206 @default.
• W4282938106 cites W2993894543 @default.
• W4282938106 cites W3006033724 @default.
• W4282938106 cites W3025060722 @default.
• W4282938106 cites W3047402958 @default.
• W4282938106 cites W3047880178 @default.
• W4282938106 cites W3081528139 @default.
• W4282938106 cites W3085648431 @default.
• W4282938106 cites W3087350907 @default.
• W4282938106 cites W3091873738 @default.
• W4282938106 cites W3099179344 @default.
• W4282938106 cites W3106188259 @default.
• W4282938106 cites W3112105690 @default.
• W4282938106 cites W3119915862 @default.
• W4282938106 cites W3125524953 @default.
• W4282938106 cites W3131634425 @default.
• W4282938106 cites W3149376923 @default.
• W4282938106 cites W3152578692 @default.
• W4282938106 cites W3156830838 @default.
• W4282938106 cites W3160822910 @default.
• W4282938106 cites W3162303048 @default.
• W4282938106 cites W3172855121 @default.
• W4282938106 cites W3178245612 @default.
• W4282938106 cites W3197241550 @default.
• W4282938106 cites W3198476511 @default.
• W4282938106 cites W3210860076 @default.
• W4282938106 cites W3211973977 @default.
• W4282938106 cites W3214158901 @default.
• W4282938106 cites W3214960152 @default.
• W4282938106 cites W4214884216 @default.
• W4282938106 doi "https://doi.org/10.1038/s41587-022-01341-y" @default.
• W4282938106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35668323" @default.
• W4282938106 hasPublicationYear "2022" @default.
• W4282938106 type Work @default.
• W4282938106 citedByCount "15" @default.
• W4282938106 countsByYear W42829381062022 @default.
• W4282938106 countsByYear W42829381062023 @default.
• W4282938106 crossrefType "journal-article" @default.
• W4282938106 hasAuthorship W4282938106A5000074913 @default.
• W4282938106 hasAuthorship W4282938106A5026663934 @default.
• W4282938106 hasAuthorship W4282938106A5028716177 @default.
• W4282938106 hasAuthorship W4282938106A5040881212 @default.
• W4282938106 hasAuthorship W4282938106A5043076766 @default.

• next