Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282938612> ?p ?o ?g. }
- W4282938612 endingPage "773" @default.
- W4282938612 startingPage "762" @default.
- W4282938612 abstract "Mucins are large gel-forming polymers inside the mucus barrier that inhibit the yeast-to-hyphal transition of Candida albicans, a key virulence trait of this important human fungal pathogen. However, the molecular motifs in mucins that inhibit filamentation remain unclear despite their potential for therapeutic interventions. Here, we determined that mucins display an abundance of virulence-attenuating molecules in the form of mucin O-glycans. We isolated and cataloged >100 mucin O-glycans from three major mucosal surfaces and established that they suppress filamentation and related phenotypes relevant to infection, including surface adhesion, biofilm formation and cross-kingdom competition between C. albicans and the bacterium Pseudomonas aeruginosa. Using synthetic O-glycans, we identified three structures (core 1, core 1 + fucose and core 2 + galactose) that are sufficient to inhibit filamentation with potency comparable to the complex O-glycan pool. Overall, this work identifies mucin O-glycans as host molecules with untapped therapeutic potential to manage fungal pathogens." @default.
- W4282938612 created "2022-06-16" @default.
- W4282938612 creator A5003488124 @default.
- W4282938612 creator A5009270827 @default.
- W4282938612 creator A5016397939 @default.
- W4282938612 creator A5018986675 @default.
- W4282938612 creator A5023341393 @default.
- W4282938612 creator A5024622354 @default.
- W4282938612 creator A5026950078 @default.
- W4282938612 creator A5036093282 @default.
- W4282938612 creator A5039254217 @default.
- W4282938612 creator A5043688508 @default.
- W4282938612 creator A5055078294 @default.
- W4282938612 creator A5056310890 @default.
- W4282938612 creator A5061597642 @default.
- W4282938612 creator A5065444339 @default.
- W4282938612 creator A5076155587 @default.
- W4282938612 creator A5077008466 @default.
- W4282938612 creator A5077591315 @default.
- W4282938612 creator A5078952644 @default.
- W4282938612 date "2022-06-06" @default.
- W4282938612 modified "2023-10-01" @default.
- W4282938612 title "Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity" @default.
- W4282938612 cites W1501227022 @default.
- W4282938612 cites W1907372042 @default.
- W4282938612 cites W197316820 @default.
- W4282938612 cites W1976830636 @default.
- W4282938612 cites W1978743314 @default.
- W4282938612 cites W1982151856 @default.
- W4282938612 cites W1986668372 @default.
- W4282938612 cites W1990652136 @default.
- W4282938612 cites W1993800351 @default.
- W4282938612 cites W1994403582 @default.
- W4282938612 cites W1995935584 @default.
- W4282938612 cites W1997437177 @default.
- W4282938612 cites W2002613342 @default.
- W4282938612 cites W2018448767 @default.
- W4282938612 cites W2021225422 @default.
- W4282938612 cites W2040484264 @default.
- W4282938612 cites W2042304168 @default.
- W4282938612 cites W2044434705 @default.
- W4282938612 cites W2049012206 @default.
- W4282938612 cites W2053937029 @default.
- W4282938612 cites W2057049168 @default.
- W4282938612 cites W2057583358 @default.
- W4282938612 cites W2062503200 @default.
- W4282938612 cites W2083260383 @default.
- W4282938612 cites W2098979038 @default.
- W4282938612 cites W2101911260 @default.
- W4282938612 cites W2102861863 @default.
- W4282938612 cites W2107018762 @default.
- W4282938612 cites W2110905563 @default.
- W4282938612 cites W2113880496 @default.
- W4282938612 cites W2114409750 @default.
- W4282938612 cites W2132092226 @default.
- W4282938612 cites W2137526110 @default.
- W4282938612 cites W2138207763 @default.
- W4282938612 cites W2141572369 @default.
- W4282938612 cites W2142140971 @default.
- W4282938612 cites W2145725787 @default.
- W4282938612 cites W2146512944 @default.
- W4282938612 cites W2157151790 @default.
- W4282938612 cites W2157594666 @default.
- W4282938612 cites W2163110564 @default.
- W4282938612 cites W2170764510 @default.
- W4282938612 cites W2179438025 @default.
- W4282938612 cites W2555188306 @default.
- W4282938612 cites W2595497888 @default.
- W4282938612 cites W2755985677 @default.
- W4282938612 cites W2761420273 @default.
- W4282938612 cites W2765666007 @default.
- W4282938612 cites W2917101543 @default.
- W4282938612 cites W2917207851 @default.
- W4282938612 cites W2939138733 @default.
- W4282938612 cites W2965934528 @default.
- W4282938612 cites W2979382042 @default.
- W4282938612 cites W3012389880 @default.
- W4282938612 cites W3040007890 @default.
- W4282938612 cites W3047565428 @default.
- W4282938612 cites W3099527489 @default.
- W4282938612 cites W3104349756 @default.
- W4282938612 cites W3163962956 @default.
- W4282938612 cites W4211178015 @default.
- W4282938612 cites W4234503887 @default.
- W4282938612 doi "https://doi.org/10.1038/s41589-022-01035-1" @default.
- W4282938612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35668191" @default.
- W4282938612 hasPublicationYear "2022" @default.
- W4282938612 type Work @default.
- W4282938612 citedByCount "15" @default.
- W4282938612 countsByYear W42829386122022 @default.
- W4282938612 countsByYear W42829386122023 @default.
- W4282938612 crossrefType "journal-article" @default.
- W4282938612 hasAuthorship W4282938612A5003488124 @default.
- W4282938612 hasAuthorship W4282938612A5009270827 @default.
- W4282938612 hasAuthorship W4282938612A5016397939 @default.
- W4282938612 hasAuthorship W4282938612A5018986675 @default.
- W4282938612 hasAuthorship W4282938612A5023341393 @default.
- W4282938612 hasAuthorship W4282938612A5024622354 @default.