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• W4282938934 abstract "ABSTRACTExogenous oestrogen 17β-oestradiol (E2) has been shown to effectively induce feminization in teleosts. However, the molecular mechanisms underlying the process remain unclear. Here, we determined global DNA methylation and gene expression profiles of channel catfish (Ictalurus punctatus) during early sex differentiation after E2 treatment. Overall, the levels of global DNA methylation after E2 treatment were not significantly different from those of controls. However, a specific set of genes were differentially methylated, which included many sex differentiation-related pathways, such as MARK signalling, adrenergic signalling, Wnt signalling, GnRH signalling, ErbB signalling, and ECM–receptor interactions. Many genes involved in these pathways were also differentially expressed after E2 treatment. Specifically, E2 treatments resulted in upregulation of female-related genes and downregulation of male-related genes in genetic males during sex reversal. However, E2-induced sex reversal did not cause sex-specific changes in methylation profiles or gene expression within the sex determination region (SDR) on chromosome 4, suggesting that E2-induced sex reversal was a downstream process independent of the sex determination process that was regulated by sex-specific methylation within the SDR.KEYWORDS: Sex reversalmethylationoestrogentranscriptionsex differentiationteleost AcknowledgmentsThis project was supported by the Agriculture and Food Research Initiative (AFRI) Competitive Grants 2019-67015-29409 from the USDA National Institute of Food and Agriculture (NIFA) Animal Reproduction Program.Data availability statementThe authors confirm that the data supporting the findings of this study are available within the article [and/or] its supplementary materials. The short sequence reads were deposited to NCBI SRA https://www.ncbi.nlm.nih.gov/sra/docs/ with the BioProject ID PRJNA826119.Disclosure statementNo potential conflict of interest was reported by the author(s).Ethical approvalExperimental protocols of animal care and tissue collection were approved by the Auburn University Institutional Animal Care and Use Committee (AU-IACUC).Supplementary materialSupplemental data for this article can be accessed online at https://doi.org/10.1080/15592294.2022.2086725Additional informationFundingThis work was supported by the National Institute of Food and Agriculture [2019-67015-29409]." @default.
• W4282938934 created "2022-06-16" @default.
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• W4282938934 date "2022-06-15" @default.
• W4282938934 modified "2023-10-07" @default.
• W4282938934 title "Feminization of channel catfish with 17β-oestradiol involves methylation and expression of a specific set of genes independent of the sex determination region" @default.
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