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- W4282939884 abstract "To investigate the molecular mechanism of one patient with abnormal serological phenotype in RhD and discuss the transfusion strategy.The RhD variant sample was screened from a patient with IgM type anti-D antibody and further determined by three different sources of anti-D antibodies. Ten exons and the adjacent introns of the RHD gene were amplified, purified and sequenced. RhCE phenotypes and RHCE genotypes were detected.The patient with Rh variant showed abnormal results of serological tests. The RHD gene sequence analysis showed that the RHD*01W.01 with a variation (c.809T>G, p.Val270Gly) in exon 6 of the RHD gene was found in the patient. The RhCE phenotype was CcEe. The genotyping results of RHCE were consistent with the serological typing results.The Rh variant of the patient is RHD*01W.01, these findings indicate that RhD variants should be analyzed by molecular assays for the sake of safe transfusion.Rh弱D1变异型鉴定及输血策略讨论.分析血清学表现异常的1例RhD抗原变异体患者基因变异情况，探讨输血策略.RhD来源于一位IgM抗-D初筛为弱阳性的患者，经3种不同来源抗血清鉴定RhD变异体，对RHD基因10个外显子及邻近的内含子进行PCR扩增、纯化及测序，并检测RhCE抗原分型和RHCE基因型.患者的血清学表现为D变异型，RHD基因测序分析显示，第6外显子的809位碱基发生T>G变异（c.809T>G，p.Val270Gly），为RHD*01W.01型；RhCE抗原分型为CcEe，RHCE基因型结果与血清学表型一致.此患者RhD抗原变异体为RHD*01W.01型，应对D变异体进行基因分型研究，进而采取安全有效的输血策略." @default.
- W4282939884 created "2022-06-16" @default.
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- W4282939884 date "2022-06-01" @default.
- W4282939884 modified "2023-10-01" @default.
- W4282939884 title "[Identification of Weak D Type 1 in Rh Blood Group System and Discussion of Transfusion Strategy]." @default.
- W4282939884 doi "https://doi.org/10.19746/j.cnki.issn.1009-2137.2022.03.032" @default.
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