Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282941906> ?p ?o ?g. }
- W4282941906 endingPage "710" @default.
- W4282941906 startingPage "697" @default.
- W4282941906 abstract "Abstract The Piezo channel family, including Piezo1 and Piezo2, includes essential mechanosensitive transduction molecules in mammals. Functioning in the conversion of mechanical signals to biological signals to regulate a plethora of physiological processes, Piezo channels, which have a unique homotrimeric three-blade propeller-shaped structure, utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Piezo channels have a wide range of biological roles in various human systems, both in vitro and in vivo. Currently, there is a lack of comprehensive understanding of their antagonists and agonists, and therefore further investigation is needed. Remarkably, increasingly compelling evidence demonstrates that Piezo channel function in the urinary system is important. This review article systematically summarizes the existing evidence of the importance of Piezo channels, including protein structure, mechanogating mechanisms, and pharmacological characteristics, with a particular focus on their physiological and pathophysiological roles in the urinary system. Collectively, this review aims to provide a direction for future clinical applications in urinary system diseases." @default.
- W4282941906 created "2022-06-16" @default.
- W4282941906 creator A5013794668 @default.
- W4282941906 creator A5016082098 @default.
- W4282941906 creator A5047806041 @default.
- W4282941906 creator A5052394090 @default.
- W4282941906 creator A5065312383 @default.
- W4282941906 date "2022-06-14" @default.
- W4282941906 modified "2023-10-14" @default.
- W4282941906 title "Piezo channels in the urinary system" @default.
- W4282941906 cites W1533971716 @default.
- W4282941906 cites W1601034261 @default.
- W4282941906 cites W1684606992 @default.
- W4282941906 cites W1767633497 @default.
- W4282941906 cites W1921540853 @default.
- W4282941906 cites W1928745964 @default.
- W4282941906 cites W1972071814 @default.
- W4282941906 cites W1973994485 @default.
- W4282941906 cites W1975854407 @default.
- W4282941906 cites W1978838803 @default.
- W4282941906 cites W1979069664 @default.
- W4282941906 cites W1982652247 @default.
- W4282941906 cites W1983897833 @default.
- W4282941906 cites W1984602413 @default.
- W4282941906 cites W1987139248 @default.
- W4282941906 cites W1988378570 @default.
- W4282941906 cites W1989979419 @default.
- W4282941906 cites W1991643569 @default.
- W4282941906 cites W1996711923 @default.
- W4282941906 cites W1999720993 @default.
- W4282941906 cites W2004809846 @default.
- W4282941906 cites W2022651241 @default.
- W4282941906 cites W2023072510 @default.
- W4282941906 cites W2033485430 @default.
- W4282941906 cites W2041940817 @default.
- W4282941906 cites W2050448556 @default.
- W4282941906 cites W2053355175 @default.
- W4282941906 cites W2055774746 @default.
- W4282941906 cites W2062950942 @default.
- W4282941906 cites W2070099436 @default.
- W4282941906 cites W2072024311 @default.
- W4282941906 cites W2074739115 @default.
- W4282941906 cites W2076047381 @default.
- W4282941906 cites W2077981632 @default.
- W4282941906 cites W2079597091 @default.
- W4282941906 cites W2083824794 @default.
- W4282941906 cites W2096926884 @default.
- W4282941906 cites W2101859335 @default.
- W4282941906 cites W2104154771 @default.
- W4282941906 cites W2104989250 @default.
- W4282941906 cites W2107634021 @default.
- W4282941906 cites W2113018006 @default.
- W4282941906 cites W2114339186 @default.
- W4282941906 cites W2120259730 @default.
- W4282941906 cites W2125942201 @default.
- W4282941906 cites W2134182567 @default.
- W4282941906 cites W2134577432 @default.
- W4282941906 cites W2143897453 @default.
- W4282941906 cites W2149079172 @default.
- W4282941906 cites W2161535250 @default.
- W4282941906 cites W2166599924 @default.
- W4282941906 cites W2171246574 @default.
- W4282941906 cites W2184968222 @default.
- W4282941906 cites W2193068214 @default.
- W4282941906 cites W2256087259 @default.
- W4282941906 cites W2260991120 @default.
- W4282941906 cites W2272911234 @default.
- W4282941906 cites W2286255985 @default.
- W4282941906 cites W2301678655 @default.
- W4282941906 cites W2322467581 @default.
- W4282941906 cites W2334551212 @default.
- W4282941906 cites W2400045719 @default.
- W4282941906 cites W2439478085 @default.
- W4282941906 cites W2460164747 @default.
- W4282941906 cites W2505300434 @default.
- W4282941906 cites W2520576094 @default.
- W4282941906 cites W2522174175 @default.
- W4282941906 cites W2530833951 @default.
- W4282941906 cites W2534139145 @default.
- W4282941906 cites W2542750476 @default.
- W4282941906 cites W2561631604 @default.
- W4282941906 cites W2566932600 @default.
- W4282941906 cites W2568618669 @default.
- W4282941906 cites W2568917699 @default.
- W4282941906 cites W2570138915 @default.
- W4282941906 cites W2571743364 @default.
- W4282941906 cites W2588123864 @default.
- W4282941906 cites W2599561734 @default.
- W4282941906 cites W2604154469 @default.
- W4282941906 cites W2605543068 @default.
- W4282941906 cites W2606450485 @default.
- W4282941906 cites W2645647341 @default.
- W4282941906 cites W2724183530 @default.
- W4282941906 cites W2747918806 @default.
- W4282941906 cites W2750938041 @default.
- W4282941906 cites W2753378915 @default.
- W4282941906 cites W2754574141 @default.
- W4282941906 cites W2765101069 @default.