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• W4282942007 abstract "Objective: To compare the anesthetic effects of mivacurium and cisatracurium besylate in laser laryngeal microsurgery, and to provide clinical evidence and reference for further optimization of muscle relaxation application. Methods: From October 2021 to January 2022, fifty-six patients of Beijing Tongren Hospital, Capital Medical University, scheduled for laser laryngeal microsurgery with general anesthesia, were enrolled. These patients, aged 18-65 years old, 25 males and 31 females, were divided into two groups (n=28) by random number table method. Cisatracurium besylate group (group C): cisatracurium besylate was injected at 0.1 mg/kg. Normal saline was continuously infused during operation. Mivacurium group (group M):Mivacurium was injected at 0.25 mg/kg and continuously infused at 0.3 mg·kg-1·h-1 during operation.The intubation time, the extubation time, recovery index, Cooper's score, Cormack-Lehane grade, surgical condition grade, postoperative residual neuromuscular block and allergic related adverse events were compared between the two groups. Results: The intubation time and the extubation time of group M were (3.7±1.1) and (16.2±5.0) min, which were statistically significant shorter than those of group C (4.9±0.7) and (26.4±8.6) min (all P<0.05). The recovery indexes of the patients in group M and group C were (4.5±3.4) and (6.2±5.0) min. The Cooper's scores of the two groups were both 9(9, 9). The Cormack-Lehane grades of the two groups were all grade Ⅰ. The number of cases with good/excellent surgical condition grades in group M and group C were 5/23 and 0/28. There were no significant differences in recovery index, Cooper's score, Cormack-Lehane grades and surgical condition grades between the two groups (all P>0.05). The TOF ratio of group M in the post anesthesia care unit (PACU) was (95.7±2.6) %, which was significantly higher than (92.9±3.9) % of group C(P=0.015). There were no significant differences in MAP and HR between the two groups at different time points (all P>0.05). The incidence of skin flushing in group M and group C was 10.7% (3/28) and 0, and the difference was not statistically significant (P=0.074). There were no cases of severe hypotension, significantly elevated airway pressure or airway spasm in both groups. Conclusion: In laser laryngeal microsurgery, compared with cisatracurium besylate, mivacurium has shorter intubation time and extubation time, stable hemodynamics, no significant increase in allergic related adverse events. mivacurium is safe and effective.目的： 比较米库氯铵和苯磺顺阿曲库铵在激光喉显微手术中的麻醉效果，为进一步优化肌松方案提供临床依据。 方法： 选择2021年10月至2022年1月首都医科大学附属北京同仁医院择期拟行全身麻醉下激光喉显微手术的患者56例。年龄18~65岁，男25例，女31例，采用随机数字表法分为两组（n=28）。苯磺顺阿曲库铵组（C组）：苯磺顺阿曲库铵0.1 mg/kg诱导，生理盐水术中持续输注；米库氯铵组（M组）：米库氯铵0.25 mg/kg诱导，0.3 mg·kg-1·h-1术中持续输注。比较两组患者的插管时间、拔管时间、恢复指数、Cooper′s 气管插管评分、C-L喉镜暴露分级、手术条件分级、术后肌松残余、过敏相关不良事件等。 结果： M组患者的插管时间和拔管时间分别为（3.7±1.1）、（16.2±5.0）min，短于C组的（4.9±0.7）、（26.4±8.6）min（均P<0.05）；M组和C组患者的恢复指数分别为（4.5±3.4）、（6.2±5.0）min，Cooper′s 评分［M（Q1，Q3）］均为9（9，9）分，C-L喉镜暴露分级均为Ⅰ级，手术条件分级比例（良/优）分别为5/23、0/28，差异均无统计学意义（均P>0.05）；M组患者在麻醉后监测治疗室（PACU）的四个成串刺激（TOF）值为（95.7±2.6）%，高于C组的（92.9±3.9）%（P=0.015）；两组患者在不同时间点的平均动脉压、心率比较差异均无统计学意义（均P>0.05）。M组和C组患者皮肤潮红发生率分别为10.7%（3/28）、0，差异无统计学意义（P=0.074）；两组患者均未发生严重低血压、气道压显著升高或气道痉挛。 结论： 在激光喉显微手术中，米库氯铵比苯磺顺阿曲库铵的插管时间、拔管时间更短，血流动力学平稳，过敏相关不良事件未见明显增加，安全有效。." @default.
• W4282942007 created "2022-06-16" @default.
• W4282942007 date "2022-06-07" @default.
• W4282942007 modified "2023-09-29" @default.
• W4282942007 title "[Comparison of the anesthetic effects of mivacurium and cisatracurium besylate in laser laryngeal microsurgery]." @default.
• W4282942007 doi "https://doi.org/10.3760/cma.j.cn112137-20220204-00234" @default.
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