Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282942158> ?p ?o ?g. }
- W4282942158 abstract "RNA interference (RNAi) is a primitive evolutionary mechanism developed to escape incorporation of foreign genetic material. siRNA has been instrumental in achieving the therapeutic potential of RNAi by theoretically silencing any gene of interest in a reversible and sequence-specific manner. Extrinsically administered siRNA generally needs a delivery vehicle to span across different physiological barriers and load into the RISC complex in the cytoplasm in its functional form to show its efficacy. This review discusses the designing principles and examples of different classes of delivery vehicles that have proved to be efficient in RNAi therapeutics. We also briefly discuss the role of RNAi therapeutics in genetic and rare diseases, epigenetic modifications, immunomodulation and combination modality to inch closer in creating a personalized therapy for metastatic cancer. At the end, we present, strategies and look into the opportunities to develop efficient delivery vehicles for RNAi which can be translated into clinics." @default.
- W4282942158 created "2022-06-16" @default.
- W4282942158 creator A5003320776 @default.
- W4282942158 creator A5013646416 @default.
- W4282942158 creator A5020086176 @default.
- W4282942158 creator A5034666842 @default.
- W4282942158 creator A5055369909 @default.
- W4282942158 creator A5084155277 @default.
- W4282942158 creator A5090326427 @default.
- W4282942158 date "2022-06-30" @default.
- W4282942158 modified "2023-10-14" @default.
- W4282942158 title "Emerging Approaches for Enabling RNAi Therapeutics" @default.
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