Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282942516> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4282942516 abstract "Abstract Background Cluster of differentiation (CD) 73, encoded by the NT5E gene, plays important enzymatic and non-enzymatic roles in cells. There is growing evidence show that CD73 is a key regulator in the development of tumor. Nasopharyngeal carcinoma (NPC) is one of the most common cancers in east and southeast Asia. It is urgent to know more about the mechanism of NPC development and find diagnose markers for the patients. Methods and Results Western blot, IHC and qRT-PCR were used to investigate the expression level of CD73 in NPC and we found NPC tissues had higher expression of CD73 than normal tissues. We also detected the relationship between its expression level with the clinicopathology and prognosis of NPC patients. The results showed CD73 expression was related to the clinical stages, lymph node metastasis and survival state of NPC patients. More importantly, patients with higher expression of CD73 had poorer prognosis. Then, CD73 was knocked down in NPC cells (CNE2 and CNE1), and the effects of CD73 on cell proliferation and migration were investigated by CCK8, colony formation, Transwell and wound-healing assays. We found knocking down the expression of CD73 in NPC cells could inhibit cells malignant phenotype. Conclusion CD73 plays important roles in NPC malignant behavior and might be used as a novel target for the diagnose and treatment of NPC." @default.
- W4282942516 created "2022-06-16" @default.
- W4282942516 creator A5005983379 @default.
- W4282942516 creator A5011052693 @default.
- W4282942516 creator A5021541475 @default.
- W4282942516 creator A5050705863 @default.
- W4282942516 creator A5056436929 @default.
- W4282942516 creator A5064358056 @default.
- W4282942516 creator A5078370650 @default.
- W4282942516 date "2022-06-15" @default.
- W4282942516 modified "2023-10-12" @default.
- W4282942516 title "Effects of abnormal expression of CD73 on malignant phenotype in nasopharyngeal carcinoma" @default.
- W4282942516 doi "https://doi.org/10.21203/rs.3.rs-1732297/v1" @default.
- W4282942516 hasPublicationYear "2022" @default.
- W4282942516 type Work @default.
- W4282942516 citedByCount "0" @default.
- W4282942516 crossrefType "posted-content" @default.
- W4282942516 hasAuthorship W4282942516A5005983379 @default.
- W4282942516 hasAuthorship W4282942516A5011052693 @default.
- W4282942516 hasAuthorship W4282942516A5021541475 @default.
- W4282942516 hasAuthorship W4282942516A5050705863 @default.
- W4282942516 hasAuthorship W4282942516A5056436929 @default.
- W4282942516 hasAuthorship W4282942516A5064358056 @default.
- W4282942516 hasAuthorship W4282942516A5078370650 @default.
- W4282942516 hasBestOaLocation W42829425161 @default.
- W4282942516 hasConcept C104317684 @default.
- W4282942516 hasConcept C121608353 @default.
- W4282942516 hasConcept C126322002 @default.
- W4282942516 hasConcept C127716648 @default.
- W4282942516 hasConcept C142724271 @default.
- W4282942516 hasConcept C203014093 @default.
- W4282942516 hasConcept C204232928 @default.
- W4282942516 hasConcept C2776415932 @default.
- W4282942516 hasConcept C2777546739 @default.
- W4282942516 hasConcept C2778997737 @default.
- W4282942516 hasConcept C2779013556 @default.
- W4282942516 hasConcept C502942594 @default.
- W4282942516 hasConcept C509974204 @default.
- W4282942516 hasConcept C54355233 @default.
- W4282942516 hasConcept C71924100 @default.
- W4282942516 hasConcept C86803240 @default.
- W4282942516 hasConceptScore W4282942516C104317684 @default.
- W4282942516 hasConceptScore W4282942516C121608353 @default.
- W4282942516 hasConceptScore W4282942516C126322002 @default.
- W4282942516 hasConceptScore W4282942516C127716648 @default.
- W4282942516 hasConceptScore W4282942516C142724271 @default.
- W4282942516 hasConceptScore W4282942516C203014093 @default.
- W4282942516 hasConceptScore W4282942516C204232928 @default.
- W4282942516 hasConceptScore W4282942516C2776415932 @default.
- W4282942516 hasConceptScore W4282942516C2777546739 @default.
- W4282942516 hasConceptScore W4282942516C2778997737 @default.
- W4282942516 hasConceptScore W4282942516C2779013556 @default.
- W4282942516 hasConceptScore W4282942516C502942594 @default.
- W4282942516 hasConceptScore W4282942516C509974204 @default.
- W4282942516 hasConceptScore W4282942516C54355233 @default.
- W4282942516 hasConceptScore W4282942516C71924100 @default.
- W4282942516 hasConceptScore W4282942516C86803240 @default.
- W4282942516 hasLocation W42829425161 @default.
- W4282942516 hasOpenAccess W4282942516 @default.
- W4282942516 hasPrimaryLocation W42829425161 @default.
- W4282942516 hasRelatedWork W1184393961 @default.
- W4282942516 hasRelatedWork W1985774067 @default.
- W4282942516 hasRelatedWork W2001230109 @default.
- W4282942516 hasRelatedWork W2103085388 @default.
- W4282942516 hasRelatedWork W2140369224 @default.
- W4282942516 hasRelatedWork W2161796049 @default.
- W4282942516 hasRelatedWork W2363423024 @default.
- W4282942516 hasRelatedWork W2372253583 @default.
- W4282942516 hasRelatedWork W2378468641 @default.
- W4282942516 hasRelatedWork W2888260350 @default.
- W4282942516 isParatext "false" @default.
- W4282942516 isRetracted "false" @default.
- W4282942516 workType "article" @default.