Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282942582> ?p ?o ?g. }
- W4282942582 endingPage "103906" @default.
- W4282942582 startingPage "103906" @default.
- W4282942582 abstract "Senecio spp. is one of the most frequent plant-related poisonings in cattle. Its ingestion generates the disease seneciosis, characterized by hepatic damages. Liver biopsies and serum markers dosage are tools used in diagnosis; however, many breeding cattle are undiagnosed. MicroRNAs are non-coding RNA, stable in biological fluids. Their difference in expression levels may indicate the presence of the poisoning. We analyzed the miRNA profiling to identify potential diagnostic biomarkers for Senecio brasiliensis poisoning. The expression of miR-21, miR-885, miR-122, miR-181b, miR-30a, miR-378, and let-7 f were evaluated in the serum of exposed cattle. At least one histological change was found in liver and lower quantity of albumin and high AST and ALP were also detected. MiRNAs miR-30a, miR-378, miR-21, miR-885, and miR-122 presented significantly higher expression in intoxicated animals than in healthy animals. Furthermore, miR-122, miR-885, and, especially, miR-21 signatures demonstrated high sensitivity and specificity, with potential application for detecting poisoning. • MiR-30a, −378, −21, −885, and −122 were more expressed in intoxicated animals. • MiR-122, −885 and −21 signatures demonstrated high sensitivity and specificity. • MiRNAs can be used as biomarkers for minimally invasive seneciosis diagnostic." @default.
- W4282942582 created "2022-06-16" @default.
- W4282942582 creator A5011267275 @default.
- W4282942582 creator A5030188398 @default.
- W4282942582 creator A5047859651 @default.
- W4282942582 creator A5054176695 @default.
- W4282942582 creator A5063177340 @default.
- W4282942582 creator A5070115607 @default.
- W4282942582 creator A5076379449 @default.
- W4282942582 creator A5079257845 @default.
- W4282942582 date "2022-08-01" @default.
- W4282942582 modified "2023-10-16" @default.
- W4282942582 title "MicroRNAs as serum biomarker for Senecio brasiliensis poisoning in cattle" @default.
- W4282942582 cites W1505654555 @default.
- W4282942582 cites W1596082116 @default.
- W4282942582 cites W1640689074 @default.
- W4282942582 cites W1802593107 @default.
- W4282942582 cites W1910297422 @default.
- W4282942582 cites W1974997620 @default.
- W4282942582 cites W1976760756 @default.
- W4282942582 cites W1984678094 @default.
- W4282942582 cites W1989277040 @default.
- W4282942582 cites W1992318779 @default.
- W4282942582 cites W1992398113 @default.
- W4282942582 cites W1998404710 @default.
- W4282942582 cites W1999787016 @default.
- W4282942582 cites W2002268425 @default.
- W4282942582 cites W2006531594 @default.
- W4282942582 cites W2010035733 @default.
- W4282942582 cites W2010180766 @default.
- W4282942582 cites W2014946489 @default.
- W4282942582 cites W2015338806 @default.
- W4282942582 cites W2016200390 @default.
- W4282942582 cites W2016476680 @default.
- W4282942582 cites W2016675130 @default.
- W4282942582 cites W2026531690 @default.
- W4282942582 cites W2029375279 @default.
- W4282942582 cites W2030398171 @default.
- W4282942582 cites W2054277700 @default.
- W4282942582 cites W2054984901 @default.
- W4282942582 cites W2055776709 @default.
- W4282942582 cites W2059450038 @default.
- W4282942582 cites W2060691243 @default.
- W4282942582 cites W2065381360 @default.
- W4282942582 cites W2079075061 @default.
- W4282942582 cites W2080109550 @default.
- W4282942582 cites W2088243224 @default.
- W4282942582 cites W2089188085 @default.
- W4282942582 cites W2091122525 @default.
- W4282942582 cites W2091154547 @default.
- W4282942582 cites W2094895072 @default.
- W4282942582 cites W2104806799 @default.
- W4282942582 cites W2105423509 @default.
- W4282942582 cites W2105686255 @default.
- W4282942582 cites W2114741516 @default.
- W4282942582 cites W2156733926 @default.
- W4282942582 cites W2167715370 @default.
- W4282942582 cites W2170069771 @default.
- W4282942582 cites W2179842400 @default.
- W4282942582 cites W2193625671 @default.
- W4282942582 cites W2215714925 @default.
- W4282942582 cites W2295893099 @default.
- W4282942582 cites W2513687207 @default.
- W4282942582 cites W2517746301 @default.
- W4282942582 cites W2530032545 @default.
- W4282942582 cites W2531407311 @default.
- W4282942582 cites W2542814679 @default.
- W4282942582 cites W2549879271 @default.
- W4282942582 cites W2559819932 @default.
- W4282942582 cites W2600822593 @default.
- W4282942582 cites W2604216480 @default.
- W4282942582 cites W2737488499 @default.
- W4282942582 cites W2744731404 @default.
- W4282942582 cites W2754527362 @default.
- W4282942582 cites W2755810686 @default.
- W4282942582 cites W2762965150 @default.
- W4282942582 cites W2765192292 @default.
- W4282942582 cites W2765451139 @default.
- W4282942582 cites W2794589539 @default.
- W4282942582 cites W2794890204 @default.
- W4282942582 cites W2795547145 @default.
- W4282942582 cites W2804401579 @default.
- W4282942582 cites W2884860441 @default.
- W4282942582 cites W2886356958 @default.
- W4282942582 cites W2889198652 @default.
- W4282942582 cites W2890391525 @default.
- W4282942582 cites W2898808102 @default.
- W4282942582 cites W2990297257 @default.
- W4282942582 cites W2991066270 @default.
- W4282942582 cites W3001618156 @default.
- W4282942582 cites W3014366813 @default.
- W4282942582 cites W3029717128 @default.
- W4282942582 cites W3045265280 @default.
- W4282942582 cites W3091877675 @default.
- W4282942582 cites W3093106575 @default.
- W4282942582 cites W3098354438 @default.
- W4282942582 cites W3137125623 @default.
- W4282942582 cites W3144310889 @default.