Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282942839> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4282942839 endingPage "373" @default.
- W4282942839 startingPage "370" @default.
- W4282942839 abstract "Objective: To establish a high performance liquid chromatography method for the determination of 2-thioxothiazolidine-4-carboxylic acid (TTCA) in urine. Methods: After acidification with hydrochloric acid, TTCA in urine was first extracted by ethyl acetate with excessive sodium chloride, then gradient separated by a symmetry C18 column and then detected by a diode array detector. The quantification was based on a working curve of external standard method. Results: The linear relationship of TTCA in urine was good in the range of 0.03-10.00 mg/L, and the correlation coefficient was 0.9999. The detection limit and minimum quantitative concentration of TTCA in urine were 0.008 mg/L and 0.027 mg/L. The intra-assay precision of the method was 0.9%-1.4%, the inter-assay precision was 1.3%-3.5%, and the average recovery was 85.0%-92.7% while the concentrations of TTCA in urine was 0.8, 2.0 and 8.0 mg/L, respectively (n=6) . Conclusion: The gradient elution high performance liquid chromatography method has simple operation and high sensitivity, and it is suitable for the determination of TTCA on a low level in urine for occupational workers exposure to carbon disulfide.目的： 建立尿中2-硫代噻唑烷-4-羧酸（TTCA）的高效液相色谱测定方法。 方法： 尿样以盐酸酸化，加过量氯化钠作盐析剂，用乙酸乙酯萃取尿中TTCA，经反相C18色谱柱梯度条件洗脱分离，二极管阵列检测器检测，外标法工作曲线定量。 结果： 尿中TTCA在0.03~10.00 mg/L的浓度范围内线性关系良好，相关系数r为0.999 9，方法检出限为0.008 mg/L，最低定量下限为0.027 mg/L。尿中TTCA浓度为0.8、2.0和8.0 mg/L时，方法的批内精密度为0.9%~1.4%，批间精密度为1.3%~3.5%，加标回收率为85.0%~92.7%（n=6）。 结论： 该梯度洗脱高效液相色谱测定方法操作简单、灵敏度高，适用于二硫化碳接触人群尿中TTCA低浓度含量的测定。." @default.
- W4282942839 created "2022-06-16" @default.
- W4282942839 creator A5000516056 @default.
- W4282942839 creator A5034627047 @default.
- W4282942839 creator A5035356849 @default.
- W4282942839 creator A5062237239 @default.
- W4282942839 creator A5085623351 @default.
- W4282942839 date "2022-05-20" @default.
- W4282942839 modified "2023-09-27" @default.
- W4282942839 title "[Study on determination of 2-thioxothiazolidine-4-carboxylic Acid in urine by high performance liquid chromatography]." @default.
- W4282942839 doi "https://doi.org/10.3760/cma.j.cn121094-20210129-00061" @default.
- W4282942839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35680582" @default.
- W4282942839 hasPublicationYear "2022" @default.
- W4282942839 type Work @default.
- W4282942839 citedByCount "0" @default.
- W4282942839 crossrefType "journal-article" @default.
- W4282942839 hasAuthorship W4282942839A5000516056 @default.
- W4282942839 hasAuthorship W4282942839A5034627047 @default.
- W4282942839 hasAuthorship W4282942839A5035356849 @default.
- W4282942839 hasAuthorship W4282942839A5062237239 @default.
- W4282942839 hasAuthorship W4282942839A5085623351 @default.
- W4282942839 hasConcept C119128265 @default.
- W4282942839 hasConcept C178790620 @default.
- W4282942839 hasConcept C179998833 @default.
- W4282942839 hasConcept C185592680 @default.
- W4282942839 hasConcept C2779607818 @default.
- W4282942839 hasConcept C2780026642 @default.
- W4282942839 hasConcept C43617362 @default.
- W4282942839 hasConcept C537181965 @default.
- W4282942839 hasConcept C55493867 @default.
- W4282942839 hasConcept C73826308 @default.
- W4282942839 hasConceptScore W4282942839C119128265 @default.
- W4282942839 hasConceptScore W4282942839C178790620 @default.
- W4282942839 hasConceptScore W4282942839C179998833 @default.
- W4282942839 hasConceptScore W4282942839C185592680 @default.
- W4282942839 hasConceptScore W4282942839C2779607818 @default.
- W4282942839 hasConceptScore W4282942839C2780026642 @default.
- W4282942839 hasConceptScore W4282942839C43617362 @default.
- W4282942839 hasConceptScore W4282942839C537181965 @default.
- W4282942839 hasConceptScore W4282942839C55493867 @default.
- W4282942839 hasConceptScore W4282942839C73826308 @default.
- W4282942839 hasIssue "5" @default.
- W4282942839 hasLocation W42829428391 @default.
- W4282942839 hasOpenAccess W4282942839 @default.
- W4282942839 hasPrimaryLocation W42829428391 @default.
- W4282942839 hasRelatedWork W16441005 @default.
- W4282942839 hasRelatedWork W17635473 @default.
- W4282942839 hasRelatedWork W22251234 @default.
- W4282942839 hasRelatedWork W23763557 @default.
- W4282942839 hasRelatedWork W29133270 @default.
- W4282942839 hasRelatedWork W31231256 @default.
- W4282942839 hasRelatedWork W33836046 @default.
- W4282942839 hasRelatedWork W35268460 @default.
- W4282942839 hasRelatedWork W35994801 @default.
- W4282942839 hasRelatedWork W5978781 @default.
- W4282942839 hasVolume "40" @default.
- W4282942839 isParatext "false" @default.
- W4282942839 isRetracted "false" @default.
- W4282942839 workType "article" @default.