Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282945196> ?p ?o ?g. }
- W4282945196 endingPage "513" @default.
- W4282945196 startingPage "506" @default.
- W4282945196 abstract "Metformin (Met) and liraglutide (Lira) have been approved to treat type 2 diabetes mellitus and have cardioprotective effects.Human umbilical vein endothelial cells (HUVECs) were incubated with Met, Lira, or their combination in this study.Results showed that the synergistic inhibitory effect of the two drugs on HUVECs proliferation was significant (75%) after 48 hr drug exposure. In addition, either Lira or Met alone had a marked tendency to inhibit the migration of HUVECs (42% and 39%). Almost a complete inhibition (97%) was demonstrated in combinational use after 48 hr treatment. After combining these two drugs, the apoptosis rate raised to 68%, which was a significant approval of synergistic apoptosis induction of Met and Lira. The combinational group indicated a substantial increase in VEGF, PDGF, and MMP-9 at 24 hr compared with the control.This study showed that combination therapy with Lira and Met could effectively reduce cell proliferation, induce apoptosis, and inhibit cell migration in the HUVECs. This study provides evidence to support using Met in combination with Lira as a treatment option for patients with type-2 diabetes and cancer." @default.
- W4282945196 created "2022-06-16" @default.
- W4282945196 creator A5002963928 @default.
- W4282945196 creator A5023498648 @default.
- W4282945196 creator A5031841417 @default.
- W4282945196 creator A5039241592 @default.
- W4282945196 creator A5041686337 @default.
- W4282945196 creator A5043420575 @default.
- W4282945196 creator A5070531282 @default.
- W4282945196 creator A5086705861 @default.
- W4282945196 date "2022-04-01" @default.
- W4282945196 modified "2023-09-25" @default.
- W4282945196 title "Metformin exerts synergistic anti-proliferative effects with liraglutide in human umbilical vein endothelial cells (HUVECs)." @default.
- W4282945196 cites W1038585844 @default.
- W4282945196 cites W1525305507 @default.
- W4282945196 cites W1989453119 @default.
- W4282945196 cites W2008026539 @default.
- W4282945196 cites W2027742580 @default.
- W4282945196 cites W2032347891 @default.
- W4282945196 cites W2037187996 @default.
- W4282945196 cites W2052882363 @default.
- W4282945196 cites W2081283952 @default.
- W4282945196 cites W2093664485 @default.
- W4282945196 cites W2102414144 @default.
- W4282945196 cites W2104236657 @default.
- W4282945196 cites W2104634297 @default.
- W4282945196 cites W2140983197 @default.
- W4282945196 cites W2142097676 @default.
- W4282945196 cites W2157160375 @default.
- W4282945196 cites W2160980311 @default.
- W4282945196 cites W2171151314 @default.
- W4282945196 cites W2274894148 @default.
- W4282945196 cites W2301822706 @default.
- W4282945196 cites W2345340599 @default.
- W4282945196 cites W2475233216 @default.
- W4282945196 cites W2492133223 @default.
- W4282945196 cites W2537063920 @default.
- W4282945196 cites W2583152045 @default.
- W4282945196 cites W2614231898 @default.
- W4282945196 cites W2731227355 @default.
- W4282945196 cites W2755440592 @default.
- W4282945196 cites W2767825527 @default.
- W4282945196 cites W2773214455 @default.
- W4282945196 cites W2800652755 @default.
- W4282945196 cites W2808511456 @default.
- W4282945196 cites W2884044632 @default.
- W4282945196 cites W2897957750 @default.
- W4282945196 cites W2951485519 @default.
- W4282945196 cites W2954315745 @default.
- W4282945196 cites W2990541661 @default.
- W4282945196 cites W2996301762 @default.
- W4282945196 cites W2997891042 @default.
- W4282945196 cites W2998956088 @default.
- W4282945196 cites W3015945042 @default.
- W4282945196 cites W767473666 @default.
- W4282945196 doi "https://doi.org/10.22038/ijbms.2022.64117.14117" @default.
- W4282945196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35656067" @default.
- W4282945196 hasPublicationYear "2022" @default.
- W4282945196 type Work @default.
- W4282945196 citedByCount "0" @default.
- W4282945196 crossrefType "journal-article" @default.
- W4282945196 hasAuthorship W4282945196A5002963928 @default.
- W4282945196 hasAuthorship W4282945196A5023498648 @default.
- W4282945196 hasAuthorship W4282945196A5031841417 @default.
- W4282945196 hasAuthorship W4282945196A5039241592 @default.
- W4282945196 hasAuthorship W4282945196A5041686337 @default.
- W4282945196 hasAuthorship W4282945196A5043420575 @default.
- W4282945196 hasAuthorship W4282945196A5070531282 @default.
- W4282945196 hasAuthorship W4282945196A5086705861 @default.
- W4282945196 hasConcept C134018914 @default.
- W4282945196 hasConcept C139719470 @default.
- W4282945196 hasConcept C162324750 @default.
- W4282945196 hasConcept C185592680 @default.
- W4282945196 hasConcept C190283241 @default.
- W4282945196 hasConcept C202751555 @default.
- W4282945196 hasConcept C2776988154 @default.
- W4282945196 hasConcept C2777163752 @default.
- W4282945196 hasConcept C2777180221 @default.
- W4282945196 hasConcept C2777411675 @default.
- W4282945196 hasConcept C2780323712 @default.
- W4282945196 hasConcept C2781308992 @default.
- W4282945196 hasConcept C55493867 @default.
- W4282945196 hasConcept C555293320 @default.
- W4282945196 hasConcept C71924100 @default.
- W4282945196 hasConcept C98274493 @default.
- W4282945196 hasConceptScore W4282945196C134018914 @default.
- W4282945196 hasConceptScore W4282945196C139719470 @default.
- W4282945196 hasConceptScore W4282945196C162324750 @default.
- W4282945196 hasConceptScore W4282945196C185592680 @default.
- W4282945196 hasConceptScore W4282945196C190283241 @default.
- W4282945196 hasConceptScore W4282945196C202751555 @default.
- W4282945196 hasConceptScore W4282945196C2776988154 @default.
- W4282945196 hasConceptScore W4282945196C2777163752 @default.
- W4282945196 hasConceptScore W4282945196C2777180221 @default.
- W4282945196 hasConceptScore W4282945196C2777411675 @default.
- W4282945196 hasConceptScore W4282945196C2780323712 @default.
- W4282945196 hasConceptScore W4282945196C2781308992 @default.
- W4282945196 hasConceptScore W4282945196C55493867 @default.