Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282946131> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4282946131 endingPage "181" @default.
- W4282946131 startingPage "170" @default.
- W4282946131 abstract "Perilipins (PLINs), peripheral lipid droplet (LD) proteins, play important roles in lipid accumulation and maturation in adipocytes. The relationship between PLIN family proteins and macrophage polarization in atherosclerosis has not been elucidated.The experiments used tissues from human arteries of 65 patients who had undergone a carotid endarterectomy, and cultured macrophages generated from healthy human peripheral blood mononuclear cells.Plaque immunohistochemistry demonstrated co-expression of PLIN1 and PLIN2 in both symptomatic (n=31) and asymptomatic patients (n=34). PLIN2 mRNA expression increased 3.38-fold in the symptomatic group compared with those from asymptomatic. PLIN1 was not expressed on small LDs at a shorter incubation but was on large LDs at longer incubation with oxidized LDL and VLDL, while PLIN2 was observed after 24 h and increased with a longer incubation in cultured M1 macrophage. In M2 macrophages, PLIN1 was seen as early as 24 h following incubation with VLDL, and LD size increased with longer incubation. PLIN1 overexpression increased the size of LDs in M1 macrophages, even after a short incubation, and reduced the RNA expression of TNFA, MMP2, ABCA1, and ABCG1 versus the M1 control. Conversely, silencing of PLIN1 in M2 macrophages had the opposite effects on LD size and RNA expression.There was a relationship between macrophage polarity, cytosolic LD size, and PLIN1/PLIN2 expression levels. PLIN2 was mainly expressed in arterial plaques in symptomatic stroke patients, and associated with the inflammatory phenotype of human macrophages, while PLIN1 expression is closely associated with plaque stability and the anti-inflammatory phenotype." @default.
- W4282946131 created "2022-06-16" @default.
- W4282946131 creator A5032820934 @default.
- W4282946131 creator A5055696290 @default.
- W4282946131 creator A5078843127 @default.
- W4282946131 creator A5079071350 @default.
- W4282946131 creator A5083132381 @default.
- W4282946131 date "2023-02-01" @default.
- W4282946131 modified "2023-10-03" @default.
- W4282946131 title "Lipid Droplet Protein PLIN1 Regulates Inflammatory Polarity in Human Macrophages and is Involved in Atherosclerotic Plaque Development by Promoting Stable Lipid Storage" @default.
- W4282946131 cites W1504753880 @default.
- W4282946131 cites W1593931056 @default.
- W4282946131 cites W1966723744 @default.
- W4282946131 cites W1984874281 @default.
- W4282946131 cites W1995729577 @default.
- W4282946131 cites W2001944628 @default.
- W4282946131 cites W2014191391 @default.
- W4282946131 cites W2047113599 @default.
- W4282946131 cites W2047600616 @default.
- W4282946131 cites W2066963386 @default.
- W4282946131 cites W2072892707 @default.
- W4282946131 cites W2075231903 @default.
- W4282946131 cites W2080788427 @default.
- W4282946131 cites W2080981566 @default.
- W4282946131 cites W2096519088 @default.
- W4282946131 cites W2118796844 @default.
- W4282946131 cites W2119598335 @default.
- W4282946131 cites W2129909114 @default.
- W4282946131 cites W2131135287 @default.
- W4282946131 cites W2139192127 @default.
- W4282946131 cites W2140802932 @default.
- W4282946131 cites W2141421880 @default.
- W4282946131 cites W2147593845 @default.
- W4282946131 cites W2153579916 @default.
- W4282946131 cites W2155722642 @default.
- W4282946131 cites W2166373023 @default.
- W4282946131 cites W2194719839 @default.
- W4282946131 cites W2554722168 @default.
- W4282946131 cites W2606386991 @default.
- W4282946131 cites W2788328098 @default.
- W4282946131 cites W2898164600 @default.
- W4282946131 cites W4200401092 @default.
- W4282946131 doi "https://doi.org/10.5551/jat.63153" @default.
- W4282946131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35662076" @default.
- W4282946131 hasPublicationYear "2023" @default.
- W4282946131 type Work @default.
- W4282946131 citedByCount "3" @default.
- W4282946131 countsByYear W42829461312023 @default.
- W4282946131 crossrefType "journal-article" @default.
- W4282946131 hasAuthorship W4282946131A5032820934 @default.
- W4282946131 hasAuthorship W4282946131A5055696290 @default.
- W4282946131 hasAuthorship W4282946131A5078843127 @default.
- W4282946131 hasAuthorship W4282946131A5079071350 @default.
- W4282946131 hasAuthorship W4282946131A5083132381 @default.
- W4282946131 hasBestOaLocation W42829461311 @default.
- W4282946131 hasConcept C126322002 @default.
- W4282946131 hasConcept C134018914 @default.
- W4282946131 hasConcept C137061746 @default.
- W4282946131 hasConcept C171089720 @default.
- W4282946131 hasConcept C202751555 @default.
- W4282946131 hasConcept C25095133 @default.
- W4282946131 hasConcept C2776175234 @default.
- W4282946131 hasConcept C39567582 @default.
- W4282946131 hasConcept C55493867 @default.
- W4282946131 hasConcept C71924100 @default.
- W4282946131 hasConcept C86803240 @default.
- W4282946131 hasConceptScore W4282946131C126322002 @default.
- W4282946131 hasConceptScore W4282946131C134018914 @default.
- W4282946131 hasConceptScore W4282946131C137061746 @default.
- W4282946131 hasConceptScore W4282946131C171089720 @default.
- W4282946131 hasConceptScore W4282946131C202751555 @default.
- W4282946131 hasConceptScore W4282946131C25095133 @default.
- W4282946131 hasConceptScore W4282946131C2776175234 @default.
- W4282946131 hasConceptScore W4282946131C39567582 @default.
- W4282946131 hasConceptScore W4282946131C55493867 @default.
- W4282946131 hasConceptScore W4282946131C71924100 @default.
- W4282946131 hasConceptScore W4282946131C86803240 @default.
- W4282946131 hasIssue "2" @default.
- W4282946131 hasLocation W42829461311 @default.
- W4282946131 hasLocation W42829461312 @default.
- W4282946131 hasLocation W42829461313 @default.
- W4282946131 hasOpenAccess W4282946131 @default.
- W4282946131 hasPrimaryLocation W42829461311 @default.
- W4282946131 hasRelatedWork W1634675873 @default.
- W4282946131 hasRelatedWork W1971218426 @default.
- W4282946131 hasRelatedWork W2000149821 @default.
- W4282946131 hasRelatedWork W2078924987 @default.
- W4282946131 hasRelatedWork W2096961084 @default.
- W4282946131 hasRelatedWork W2114953965 @default.
- W4282946131 hasRelatedWork W2144886284 @default.
- W4282946131 hasRelatedWork W2156518031 @default.
- W4282946131 hasRelatedWork W2436614493 @default.
- W4282946131 hasRelatedWork W2748952813 @default.
- W4282946131 hasVolume "30" @default.
- W4282946131 isParatext "false" @default.
- W4282946131 isRetracted "false" @default.
- W4282946131 workType "article" @default.