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- W4282960533 abstract "Abstract The heterogeneity of glioblastoma multiforme (GBM) leads to poor patient prognosis. Here, we aim to investigate the mechanism through which GBM heterogeneity is coordinated to promote tumor progression. We find that proneural (PN)-GBM stem cells (GSCs) secreted dopamine (DA) and transferrin (TF), inducing the proliferation of mesenchymal (MES)-GSCs and enhancing their susceptibility toward ferroptosis. PN-GSC-derived TF stimulates MES-GSC proliferation in an iron-dependent manner. DA acts in an autocrine on PN-GSC growth in a DA receptor D1-dependent manner, while in a paracrine it induces TF receptor 1 expression in MES-GSCs to assist iron uptake and thus enhance ferroptotic vulnerability. Analysis of public datasets reveals worse prognosis of patients with heterogeneous GBM with high iron uptake than those with other GBM subtypes. Collectively, the findings here provide evidence of commensalism symbiosis that causes MES-GSCs to become iron-addicted, which in turn provides a rationale for targeting ferroptosis to treat resistant MES GBM." @default.
- W4282960533 created "2022-06-17" @default.
- W4282960533 creator A5007985227 @default.
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- W4282960533 creator A5015677553 @default.
- W4282960533 creator A5048484380 @default.
- W4282960533 creator A5055833995 @default.
- W4282960533 date "2022-06-16" @default.
- W4282960533 modified "2023-10-07" @default.
- W4282960533 title "Iron commensalism of mesenchymal glioblastoma promotes ferroptosis susceptibility upon dopamine treatment" @default.
- W4282960533 cites W1572656384 @default.
- W4282960533 cites W1653244371 @default.
- W4282960533 cites W1891848729 @default.
- W4282960533 cites W1974273159 @default.
- W4282960533 cites W1975355918 @default.
- W4282960533 cites W1997183854 @default.
- W4282960533 cites W2011728195 @default.
- W4282960533 cites W2012049731 @default.
- W4282960533 cites W2017007251 @default.
- W4282960533 cites W2024672608 @default.
- W4282960533 cites W2025183726 @default.
- W4282960533 cites W2026491871 @default.
- W4282960533 cites W2029142270 @default.
- W4282960533 cites W2030017878 @default.
- W4282960533 cites W2037404794 @default.
- W4282960533 cites W2040458067 @default.
- W4282960533 cites W2063756151 @default.
- W4282960533 cites W2068638436 @default.
- W4282960533 cites W2079487111 @default.
- W4282960533 cites W2083927153 @default.
- W4282960533 cites W2088256943 @default.
- W4282960533 cites W2089466390 @default.
- W4282960533 cites W2094683614 @default.
- W4282960533 cites W2099540110 @default.
- W4282960533 cites W2108765715 @default.
- W4282960533 cites W2113942802 @default.
- W4282960533 cites W2114843025 @default.
- W4282960533 cites W2121625674 @default.
- W4282960533 cites W2122690956 @default.
- W4282960533 cites W2123040085 @default.
- W4282960533 cites W2123106337 @default.
- W4282960533 cites W2127771118 @default.
- W4282960533 cites W2128469603 @default.
- W4282960533 cites W2130410032 @default.
- W4282960533 cites W2141055671 @default.
- W4282960533 cites W2144024165 @default.
- W4282960533 cites W2148977460 @default.
- W4282960533 cites W2149441684 @default.
- W4282960533 cites W2151208819 @default.
- W4282960533 cites W2151357246 @default.
- W4282960533 cites W2161099760 @default.
- W4282960533 cites W2161289668 @default.
- W4282960533 cites W2163294546 @default.
- W4282960533 cites W2166469535 @default.
- W4282960533 cites W2171992248 @default.
- W4282960533 cites W2252688218 @default.
- W4282960533 cites W2258066491 @default.
- W4282960533 cites W2291869867 @default.
- W4282960533 cites W2314755831 @default.
- W4282960533 cites W2507365884 @default.
- W4282960533 cites W2508132062 @default.
- W4282960533 cites W2554863679 @default.
- W4282960533 cites W2584260978 @default.
- W4282960533 cites W2586910755 @default.
- W4282960533 cites W2616749209 @default.
- W4282960533 cites W2626522020 @default.
- W4282960533 cites W2727828415 @default.
- W4282960533 cites W2740108964 @default.
- W4282960533 cites W2748329310 @default.
- W4282960533 cites W2761941966 @default.
- W4282960533 cites W2772937917 @default.
- W4282960533 cites W2802561340 @default.
- W4282960533 cites W2808930783 @default.
- W4282960533 cites W2884741638 @default.
- W4282960533 cites W2885447929 @default.
- W4282960533 cites W2914810762 @default.
- W4282960533 cites W2929298692 @default.
- W4282960533 cites W2937030578 @default.
- W4282960533 cites W2950749236 @default.
- W4282960533 cites W2971359181 @default.
- W4282960533 cites W2981700910 @default.
- W4282960533 cites W3007767645 @default.
- W4282960533 cites W3009723063 @default.
- W4282960533 cites W3015719480 @default.
- W4282960533 cites W3021221826 @default.
- W4282960533 cites W3022428126 @default.
- W4282960533 cites W3031224726 @default.
- W4282960533 cites W3047440828 @default.
- W4282960533 cites W3097232537 @default.
- W4282960533 cites W3128851051 @default.
- W4282960533 cites W3132583844 @default.
- W4282960533 cites W3135035839 @default.
- W4282960533 cites W3164052211 @default.
- W4282960533 cites W3185385391 @default.
- W4282960533 cites W4211105004 @default.
- W4282960533 cites W4211132876 @default.
- W4282960533 doi "https://doi.org/10.1038/s42003-022-03538-y" @default.
- W4282960533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35710828" @default.
- W4282960533 hasPublicationYear "2022" @default.
- W4282960533 type Work @default.