Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282960688> ?p ?o ?g. }
- W4282960688 endingPage "944" @default.
- W4282960688 startingPage "944" @default.
- W4282960688 abstract "Several approaches have produced an effective vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since millions of people are exposed to influenza virus and SARS-CoV-2, it is of great interest to develop a two-in-one vaccine that will be able to protect against infection of both viruses. We have developed a hybrid vaccine for SARS-CoV-2 and influenza viruses using influenza virus-like particles (VLP) incorporated by protein transfer with glycosylphosphatidylinositol (GPI)-anchored SARS-CoV-2 RBD fused to GM-CSF as an adjuvant. GPI-RBD-GM-CSF fusion protein was expressed in CHO-S cells, purified and incorporated onto influenza VLPs to develop the hybrid vaccine. Our results show that the hybrid vaccine induced a strong antibody response and protected mice from both influenza virus and mouse-adapted SARS-CoV-2 challenges, with vaccinated mice having significantly lower lung viral titers compared to naive mice. These results suggest that a hybrid vaccine strategy is a promising approach for developing multivalent vaccines to prevent influenza A and SARS-CoV-2 infections." @default.
- W4282960688 created "2022-06-17" @default.
- W4282960688 creator A5007681513 @default.
- W4282960688 creator A5008336615 @default.
- W4282960688 creator A5009964369 @default.
- W4282960688 creator A5013869733 @default.
- W4282960688 creator A5016371780 @default.
- W4282960688 creator A5016830792 @default.
- W4282960688 creator A5026188447 @default.
- W4282960688 creator A5026534985 @default.
- W4282960688 creator A5030546746 @default.
- W4282960688 creator A5031713882 @default.
- W4282960688 creator A5034758466 @default.
- W4282960688 creator A5044656194 @default.
- W4282960688 creator A5057802881 @default.
- W4282960688 creator A5060072950 @default.
- W4282960688 creator A5061894546 @default.
- W4282960688 creator A5066410462 @default.
- W4282960688 creator A5067139739 @default.
- W4282960688 creator A5068285388 @default.
- W4282960688 creator A5073494284 @default.
- W4282960688 creator A5081113436 @default.
- W4282960688 creator A5082196610 @default.
- W4282960688 creator A5090887063 @default.
- W4282960688 date "2022-06-14" @default.
- W4282960688 modified "2023-10-06" @default.
- W4282960688 title "Influenza Virus-like Particle-Based Hybrid Vaccine Containing RBD Induces Immunity against Influenza and SARS-CoV-2 Viruses" @default.
- W4282960688 cites W1482487875 @default.
- W4282960688 cites W1485703951 @default.
- W4282960688 cites W1493941926 @default.
- W4282960688 cites W1566615131 @default.
- W4282960688 cites W1607695063 @default.
- W4282960688 cites W1609710757 @default.
- W4282960688 cites W1617101517 @default.
- W4282960688 cites W1649131555 @default.
- W4282960688 cites W1787996156 @default.
- W4282960688 cites W1821988420 @default.
- W4282960688 cites W1978529234 @default.
- W4282960688 cites W1979341960 @default.
- W4282960688 cites W2011653164 @default.
- W4282960688 cites W2013340158 @default.
- W4282960688 cites W2023718350 @default.
- W4282960688 cites W2024238985 @default.
- W4282960688 cites W2044768277 @default.
- W4282960688 cites W2046182783 @default.
- W4282960688 cites W2061051459 @default.
- W4282960688 cites W2062757204 @default.
- W4282960688 cites W2073242835 @default.
- W4282960688 cites W2078009629 @default.
- W4282960688 cites W2092235636 @default.
- W4282960688 cites W2101838529 @default.
- W4282960688 cites W2103959341 @default.
- W4282960688 cites W2114914602 @default.
- W4282960688 cites W2150109375 @default.
- W4282960688 cites W2152403065 @default.
- W4282960688 cites W2152912310 @default.
- W4282960688 cites W2156528651 @default.
- W4282960688 cites W2159339541 @default.
- W4282960688 cites W2169258216 @default.
- W4282960688 cites W2169965860 @default.
- W4282960688 cites W2256756668 @default.
- W4282960688 cites W249403745 @default.
- W4282960688 cites W2753483322 @default.
- W4282960688 cites W2898144861 @default.
- W4282960688 cites W2963220452 @default.
- W4282960688 cites W3004280078 @default.
- W4282960688 cites W3004563347 @default.
- W4282960688 cites W3013348202 @default.
- W4282960688 cites W3014067025 @default.
- W4282960688 cites W3014553071 @default.
- W4282960688 cites W3015751519 @default.
- W4282960688 cites W3034173374 @default.
- W4282960688 cites W3047704640 @default.
- W4282960688 cites W3087207483 @default.
- W4282960688 cites W3095090886 @default.
- W4282960688 cites W3098741165 @default.
- W4282960688 cites W3119412259 @default.
- W4282960688 cites W3134129466 @default.
- W4282960688 cites W3135734644 @default.
- W4282960688 cites W3160600871 @default.
- W4282960688 cites W3162029874 @default.
- W4282960688 cites W3204768578 @default.
- W4282960688 cites W3216059092 @default.
- W4282960688 cites W4200131705 @default.
- W4282960688 cites W4212774086 @default.
- W4282960688 cites W4213148302 @default.
- W4282960688 cites W4225358271 @default.
- W4282960688 cites W4225723258 @default.
- W4282960688 cites W4232131065 @default.
- W4282960688 doi "https://doi.org/10.3390/vaccines10060944" @default.
- W4282960688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35746552" @default.
- W4282960688 hasPublicationYear "2022" @default.
- W4282960688 type Work @default.
- W4282960688 citedByCount "5" @default.
- W4282960688 countsByYear W42829606882022 @default.
- W4282960688 countsByYear W42829606882023 @default.
- W4282960688 crossrefType "journal-article" @default.
- W4282960688 hasAuthorship W4282960688A5007681513 @default.