FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282961586> ?p ?o ?g. }

• W4282961586 endingPage "439" @default.
• W4282961586 startingPage "417" @default.
• W4282961586 abstract "Depression is one of the most frequent and burdensome non-motor symptoms in Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression has a great impact on quality of life for these patients and their caregivers. Accordingly, accurate diagnosis, supported by validated scales, identification of risk factors, and recognition of motor and non-motor symptoms comorbid to depression are critical to understanding the neurobiology of depression, which in turn determines the effectiveness of dopaminergic drugs, antidepressants and non-pharmacological interventions. Recent advances using in vivo functional and structural imaging demonstrate that PD depression is underpinned by dysfunction of limbic networks and monoaminergic systems, depending on the stage of PD and its associated symptoms, including apathy, anxiety, rapid eye movement sleep behavior disorder (RBD), cognitive impairment and dementia. In particular, the evolution of serotonergic, noradrenergic, and dopaminergic dysfunction and abnormalities of limbic circuits across time, involving the anterior cingulate and orbitofrontal cortices, amygdala, thalamus and ventral striatum, help to delineate the variable expression of depression in patients with prodromal, early and advanced PD. Evidence is accumulating to support the use of dual serotonin and noradrenaline reuptake inhibitors (desipramine, nortriptyline, venlafaxine) in patients with PD and moderate to severe depression, while selective serotonin reuptake inhibitors, repetitive transcranial magnetic stimulation and cognitive behavioral therapy may also be considered. In all patients, recent findings advocate that optimization of dopamine replacement therapy and evaluation of deep brain stimulation of the subthalamic nucleus to improve motor symptoms represents an important first step, in addition to physical activity. Overall, this review indicates that increasing understanding of neurobiological changes help to implement a roadmap of tailored interventions for patients with PD and depression, depending on the stage and comorbid symptoms underlying PD subtypes and their prognosis." @default.
• W4282961586 created "2022-06-17" @default.
• W4282961586 creator A5019348696 @default.
• W4282961586 creator A5034341014 @default.
• W4282961586 creator A5038392407 @default.
• W4282961586 creator A5042915964 @default.
• W4282961586 creator A5050926946 @default.
• W4282961586 date "2022-06-01" @default.
• W4282961586 modified "2023-10-17" @default.
• W4282961586 title "Depression in Patients with Parkinson’s Disease: Current Understanding of its Neurobiology and Implications for Treatment" @default.
• W4282961586 cites W121091050 @default.
• W4282961586 cites W1486943840 @default.
• W4282961586 cites W1571372337 @default.
• W4282961586 cites W1576172814 @default.
• W4282961586 cites W1583624660 @default.
• W4282961586 cites W1623400675 @default.
• W4282961586 cites W1649311764 @default.
• W4282961586 cites W1654896864 @default.
• W4282961586 cites W1728922767 @default.
• W4282961586 cites W1750226992 @default.
• W4282961586 cites W1826105565 @default.
• W4282961586 cites W1849784746 @default.
• W4282961586 cites W186129900 @default.
• W4282961586 cites W1879602048 @default.
• W4282961586 cites W1894822386 @default.
• W4282961586 cites W1924412317 @default.
• W4282961586 cites W1925250651 @default.
• W4282961586 cites W1940826098 @default.
• W4282961586 cites W1964551143 @default.
• W4282961586 cites W1964951154 @default.
• W4282961586 cites W1965358782 @default.
• W4282961586 cites W1967498373 @default.
• W4282961586 cites W1968726432 @default.
• W4282961586 cites W1969355958 @default.
• W4282961586 cites W1969842477 @default.
• W4282961586 cites W1969926186 @default.
• W4282961586 cites W1970065851 @default.
• W4282961586 cites W1975546859 @default.
• W4282961586 cites W1977576077 @default.
• W4282961586 cites W1978531300 @default.
• W4282961586 cites W1980281322 @default.
• W4282961586 cites W1980749912 @default.
• W4282961586 cites W1982091811 @default.
• W4282961586 cites W1982391914 @default.
• W4282961586 cites W1984797595 @default.
• W4282961586 cites W1987034315 @default.
• W4282961586 cites W1988772153 @default.
• W4282961586 cites W1989438307 @default.
• W4282961586 cites W1989989056 @default.
• W4282961586 cites W1990103681 @default.
• W4282961586 cites W1993194746 @default.
• W4282961586 cites W1993790483 @default.
• W4282961586 cites W1995194331 @default.
• W4282961586 cites W1997185618 @default.
• W4282961586 cites W1997302489 @default.
• W4282961586 cites W1997537030 @default.
• W4282961586 cites W1999630261 @default.
• W4282961586 cites W1999738332 @default.
• W4282961586 cites W1999950938 @default.
• W4282961586 cites W2000123680 @default.
• W4282961586 cites W2001666803 @default.
• W4282961586 cites W2002983139 @default.
• W4282961586 cites W2003660587 @default.
• W4282961586 cites W2003982930 @default.
• W4282961586 cites W2004103828 @default.
• W4282961586 cites W2005456488 @default.
• W4282961586 cites W2005532083 @default.
• W4282961586 cites W2006373435 @default.
• W4282961586 cites W2007567369 @default.
• W4282961586 cites W2007704800 @default.
• W4282961586 cites W2009501816 @default.
• W4282961586 cites W2009552365 @default.
• W4282961586 cites W2012392954 @default.
• W4282961586 cites W2015267200 @default.
• W4282961586 cites W2016289276 @default.
• W4282961586 cites W2016620552 @default.
• W4282961586 cites W2017156283 @default.
• W4282961586 cites W2018188468 @default.
• W4282961586 cites W2020230250 @default.
• W4282961586 cites W2020250303 @default.
• W4282961586 cites W2020522596 @default.
• W4282961586 cites W2020996348 @default.
• W4282961586 cites W2021056351 @default.
• W4282961586 cites W2022532739 @default.
• W4282961586 cites W2022533807 @default.
• W4282961586 cites W2022947342 @default.
• W4282961586 cites W2024737755 @default.
• W4282961586 cites W2025720422 @default.
• W4282961586 cites W2025843054 @default.
• W4282961586 cites W2026884117 @default.
• W4282961586 cites W2027845654 @default.
• W4282961586 cites W2028064682 @default.
• W4282961586 cites W2029624330 @default.
• W4282961586 cites W2030093766 @default.
• W4282961586 cites W2030755872 @default.
• W4282961586 cites W2032616672 @default.
• W4282961586 cites W2033023107 @default.
• W4282961586 cites W2033623894 @default.

• next