Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282965362> ?p ?o ?g. }
- W4282965362 endingPage "911" @default.
- W4282965362 startingPage "911" @default.
- W4282965362 abstract "C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of the heart, respectively, CNP is regarded as an autocrine/paracrine regulator with broad expression in the body. Because of its low expression levels compared to ANP and BNP, early studies failed to show its existence and role in the heart. However, recent studies have revealed the physiological and pathophysiological importance of CNP in the heart; in concert with the distribution of its specific natriuretic peptide receptor-B (NPR-B), CNP has come to be regarded as the major heart-protective natriuretic peptide in the failed heart. NPR-B generates intracellular cyclic guanosine 3′,5′-monophosphate (cGMP) upon CNP binding, followed by various molecular effects including the activation of cGMP-dependent protein kinases, which generates diverse cytoprotective actions in cardiomyocytes, as well as in cardiac fibroblasts. CNP exerts negative inotropic and positive lusitropic responses in both normal and failing heart models. Furthermore, osteocrin, the intrinsic and specific ligand for the clearance receptor for natriuretic peptides, can augment the effects of CNP and may supply a novel therapeutic strategy for cardiac protection." @default.
- W4282965362 created "2022-06-17" @default.
- W4282965362 creator A5053373538 @default.
- W4282965362 date "2022-06-14" @default.
- W4282965362 modified "2023-10-18" @default.
- W4282965362 title "Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart" @default.
- W4282965362 cites W1496206652 @default.
- W4282965362 cites W1530911438 @default.
- W4282965362 cites W1537905458 @default.
- W4282965362 cites W1542279315 @default.
- W4282965362 cites W1553668020 @default.
- W4282965362 cites W1770829436 @default.
- W4282965362 cites W1910149726 @default.
- W4282965362 cites W1959432500 @default.
- W4282965362 cites W1965162414 @default.
- W4282965362 cites W1967586250 @default.
- W4282965362 cites W1968130104 @default.
- W4282965362 cites W1968740258 @default.
- W4282965362 cites W1970184826 @default.
- W4282965362 cites W1970880226 @default.
- W4282965362 cites W1971172250 @default.
- W4282965362 cites W1971583678 @default.
- W4282965362 cites W1975213526 @default.
- W4282965362 cites W1975748795 @default.
- W4282965362 cites W1976078806 @default.
- W4282965362 cites W1977410653 @default.
- W4282965362 cites W1979659033 @default.
- W4282965362 cites W1980783383 @default.
- W4282965362 cites W1982121289 @default.
- W4282965362 cites W1985951474 @default.
- W4282965362 cites W1991892051 @default.
- W4282965362 cites W1993536160 @default.
- W4282965362 cites W1994485752 @default.
- W4282965362 cites W1994871589 @default.
- W4282965362 cites W1995842368 @default.
- W4282965362 cites W1996482234 @default.
- W4282965362 cites W1997049660 @default.
- W4282965362 cites W2001115693 @default.
- W4282965362 cites W2003934560 @default.
- W4282965362 cites W2006189281 @default.
- W4282965362 cites W2010443928 @default.
- W4282965362 cites W2012187332 @default.
- W4282965362 cites W2015853348 @default.
- W4282965362 cites W2019530341 @default.
- W4282965362 cites W2020211786 @default.
- W4282965362 cites W2021867660 @default.
- W4282965362 cites W2022181932 @default.
- W4282965362 cites W2024105372 @default.
- W4282965362 cites W2025214867 @default.
- W4282965362 cites W2028554439 @default.
- W4282965362 cites W2029860021 @default.
- W4282965362 cites W2033155132 @default.
- W4282965362 cites W2034508878 @default.
- W4282965362 cites W2035100090 @default.
- W4282965362 cites W2037187602 @default.
- W4282965362 cites W2037761331 @default.
- W4282965362 cites W2038589125 @default.
- W4282965362 cites W2040654758 @default.
- W4282965362 cites W2043814983 @default.
- W4282965362 cites W2044657479 @default.
- W4282965362 cites W2047830824 @default.
- W4282965362 cites W2049157359 @default.
- W4282965362 cites W2050380620 @default.
- W4282965362 cites W2050434322 @default.
- W4282965362 cites W2051927271 @default.
- W4282965362 cites W2061896017 @default.
- W4282965362 cites W2063916180 @default.
- W4282965362 cites W2063918788 @default.
- W4282965362 cites W2065417808 @default.
- W4282965362 cites W2065930317 @default.
- W4282965362 cites W2066223913 @default.
- W4282965362 cites W2066581100 @default.
- W4282965362 cites W2073040810 @default.
- W4282965362 cites W2074862244 @default.
- W4282965362 cites W2079509424 @default.
- W4282965362 cites W2079686275 @default.
- W4282965362 cites W2080159477 @default.
- W4282965362 cites W2084299578 @default.
- W4282965362 cites W2084885847 @default.
- W4282965362 cites W2085011800 @default.
- W4282965362 cites W2085661728 @default.
- W4282965362 cites W2086660182 @default.
- W4282965362 cites W2087288758 @default.
- W4282965362 cites W2087394027 @default.
- W4282965362 cites W2088881200 @default.
- W4282965362 cites W2090926515 @default.
- W4282965362 cites W2093392163 @default.
- W4282965362 cites W2096722709 @default.
- W4282965362 cites W2098150638 @default.
- W4282965362 cites W2100969193 @default.
- W4282965362 cites W2102099714 @default.
- W4282965362 cites W2104083234 @default.
- W4282965362 cites W2105157791 @default.
- W4282965362 cites W2105697810 @default.
- W4282965362 cites W2110614029 @default.
- W4282965362 cites W2112893967 @default.
- W4282965362 cites W2118152368 @default.
- W4282965362 cites W2118318099 @default.