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- W4282966906 abstract "Abstract One of the important goals of cancer treatment in drug delivery systems (DSS) is to increase the concentration of the drug only around the tumor cells to prevent damage to normal cells. In this study, doxorubicin HCl (DOX) was imprinted by the cationic polymer, graphene quantum dots (GQD) Poly (methacrylic acid-co-diallyldimethylammonium chloride) (PMA-DDA-DOX). Chemical structure (PMA-DDA-DOX) was investigated and confirmed by using Fourier-transform infrared spectroscopy (FT-IR). Particle size and morphology of (PMA-DDA-DOX) was evaluated by Field Emission Scanning Electron Microscope (FE-SEM). Then the toxicity of (PMA-DDA-DOX) was investigated in vitro study. Also to evaluate the effectiveness of (PMA-DDA-DOX) in the living organism, Nanoparticles were injected into BALB/C mice containing 4T1 breast cancer cells. Then in vivo imaging was performed at the excitation wavelength of 400 nm and emission of 535 nm. The images showed that particles (PMA-DDA-DOX) had accumulated around the cancer cell." @default.
- W4282966906 created "2022-06-17" @default.
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- W4282966906 date "2022-06-16" @default.
- W4282966906 modified "2023-09-24" @default.
- W4282966906 title "Graphene quantum dots coated cationic polymer for targeted drug delivery and imaging of breast cancer" @default.
- W4282966906 doi "https://doi.org/10.21203/rs.3.rs-1740614/v1" @default.
- W4282966906 hasPublicationYear "2022" @default.
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