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- W4282968235 abstract "Cohesin is a DNA translocase that is instrumental in the folding of the genome into chromatin loops, with functional consequences on DNA-related processes. Chromatin loop length and organization likely depend on cohesin processivity, translocation rate and stability on DNA. Here, we investigate and provide a comprehensive overview of the roles of various cohesin regulators in tuning chromatin loop expansion in budding yeast Saccharomyces cerevisiae. We demonstrate that Scc2, which stimulates cohesin ATPase activity, is also essential for cohesin translocation, driving loop expansion in vivo. Smc3 acetylation during the S phase counteracts this activity through the stabilization of Pds5, which finely tunes the size and stability of loops in G2. Here, authors use targeted degradation and Hi-C in eukaryotic cells to show that acetylation of the cohesin subunit Smc3 stops loop extrusion during DNA replication by recruiting Pds5, also required for sister chromatid cohesion, and by preventing Scc2-dependent loop expansion." @default.
- W4282968235 created "2022-06-17" @default.
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- W4282968235 date "2022-06-01" @default.
- W4282968235 modified "2023-10-17" @default.
- W4282968235 title "Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops" @default.
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- W4282968235 doi "https://doi.org/10.1038/s41594-022-00780-0" @default.
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