Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282968259> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4282968259 abstract "Abstract Background: Triple-negative breast cancer (TNBC) still lacks effective treatments, and understanding the causes of its tumorigenesis and tumor progression is helpful for prognostic evaluation. N(4)-acetylcytidine (ac4C), an epigenetic modification of RNA, whose regulatory mechanism is still unclear in TNBC tumors may provide a new perspective for understanding the development of TNBC.Methods: Two pairs of TNBC patient tissues were sequenced at the genome level using acRIP-seq technology, and differential ac4C genes were identified by Robust Rank Aggregation (RRA). Then, by integrating genome-wide lncRNA expression profiles in TCGA, we constructed a co-expression network containing 180 ac4C genes and mined 1080 lncRNA gene relationship pairs. And use cox regression analysis to screen genes associated with prognosis. Additionally, drug sensitivity was predicted using a drug target network of differential ac4C genes.Results: We screened a total of 180 differential ac4c genes, of which 6 genes were significantly associated with prognosis. In addition, we screened out three lncRNAs interacting with prognostic risk genes, and the corresponding interaction pairs were LINC01614-COL3A1, OIP5-AS1-USP8 and RP5-908M14.9-TRIR. Significant ac4C genes COL3A, USP8 and TRIR1 were accurately predicted with the sensitivity of Doxorubicin and Paclitaxel, the main chemotherapy drugs in TNBC. Conclusions: This study suggests that RNA ac4C acetylation may be a potential marker of prognosis and drug sensitivity/target through the involvement of lncRNA. These results will be used as a guide for experiments." @default.
- W4282968259 created "2022-06-17" @default.
- W4282968259 creator A5006651636 @default.
- W4282968259 creator A5007542519 @default.
- W4282968259 creator A5013597705 @default.
- W4282968259 creator A5050613147 @default.
- W4282968259 creator A5058906397 @default.
- W4282968259 creator A5064562120 @default.
- W4282968259 creator A5080539307 @default.
- W4282968259 creator A5080796063 @default.
- W4282968259 creator A5086855515 @default.
- W4282968259 creator A5089711319 @default.
- W4282968259 date "2022-05-12" @default.
- W4282968259 modified "2023-09-30" @default.
- W4282968259 title "Landscape of N(4)- acetylcytidine modified genes in triple-negative breast cancer Revealing the potential markers of N(4)-acetylcytidine through acRIP-seq in triple-negative breast cancer" @default.
- W4282968259 doi "https://doi.org/10.21203/rs.3.rs-1633136/v1" @default.
- W4282968259 hasPublicationYear "2022" @default.
- W4282968259 type Work @default.
- W4282968259 citedByCount "0" @default.
- W4282968259 crossrefType "posted-content" @default.
- W4282968259 hasAuthorship W4282968259A5006651636 @default.
- W4282968259 hasAuthorship W4282968259A5007542519 @default.
- W4282968259 hasAuthorship W4282968259A5013597705 @default.
- W4282968259 hasAuthorship W4282968259A5050613147 @default.
- W4282968259 hasAuthorship W4282968259A5058906397 @default.
- W4282968259 hasAuthorship W4282968259A5064562120 @default.
- W4282968259 hasAuthorship W4282968259A5080539307 @default.
- W4282968259 hasAuthorship W4282968259A5080796063 @default.
- W4282968259 hasAuthorship W4282968259A5086855515 @default.
- W4282968259 hasAuthorship W4282968259A5089711319 @default.
- W4282968259 hasBestOaLocation W42829682591 @default.
- W4282968259 hasConcept C104317684 @default.
- W4282968259 hasConcept C121608353 @default.
- W4282968259 hasConcept C135763542 @default.
- W4282968259 hasConcept C150194340 @default.
- W4282968259 hasConcept C153209595 @default.
- W4282968259 hasConcept C162317418 @default.
- W4282968259 hasConcept C2777292972 @default.
- W4282968259 hasConcept C2780110267 @default.
- W4282968259 hasConcept C41091548 @default.
- W4282968259 hasConcept C502942594 @default.
- W4282968259 hasConcept C530470458 @default.
- W4282968259 hasConcept C54355233 @default.
- W4282968259 hasConcept C555283112 @default.
- W4282968259 hasConcept C70721500 @default.
- W4282968259 hasConcept C86803240 @default.
- W4282968259 hasConceptScore W4282968259C104317684 @default.
- W4282968259 hasConceptScore W4282968259C121608353 @default.
- W4282968259 hasConceptScore W4282968259C135763542 @default.
- W4282968259 hasConceptScore W4282968259C150194340 @default.
- W4282968259 hasConceptScore W4282968259C153209595 @default.
- W4282968259 hasConceptScore W4282968259C162317418 @default.
- W4282968259 hasConceptScore W4282968259C2777292972 @default.
- W4282968259 hasConceptScore W4282968259C2780110267 @default.
- W4282968259 hasConceptScore W4282968259C41091548 @default.
- W4282968259 hasConceptScore W4282968259C502942594 @default.
- W4282968259 hasConceptScore W4282968259C530470458 @default.
- W4282968259 hasConceptScore W4282968259C54355233 @default.
- W4282968259 hasConceptScore W4282968259C555283112 @default.
- W4282968259 hasConceptScore W4282968259C70721500 @default.
- W4282968259 hasConceptScore W4282968259C86803240 @default.
- W4282968259 hasLocation W42829682591 @default.
- W4282968259 hasOpenAccess W4282968259 @default.
- W4282968259 hasPrimaryLocation W42829682591 @default.
- W4282968259 hasRelatedWork W12565879 @default.
- W4282968259 hasRelatedWork W13070214 @default.
- W4282968259 hasRelatedWork W13408133 @default.
- W4282968259 hasRelatedWork W16537264 @default.
- W4282968259 hasRelatedWork W28937596 @default.
- W4282968259 hasRelatedWork W31114520 @default.
- W4282968259 hasRelatedWork W32323463 @default.
- W4282968259 hasRelatedWork W32699073 @default.
- W4282968259 hasRelatedWork W4094339 @default.
- W4282968259 hasRelatedWork W7746579 @default.
- W4282968259 isParatext "false" @default.
- W4282968259 isRetracted "false" @default.
- W4282968259 workType "article" @default.