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- W4282969069 abstract "Epileptic seizures are due to excessive and synchronous neural activity. Extensive modelling of seizures has been done on the neuronal level, but it remains a challenge to scale these models up to whole brain models. Measurements of the brain's activity over several spatiotemporal scales follow a power-law distribution in terms of frequency. During normal brain activity, the power-law exponent is often found to be around 2 for frequencies between a few Hz and up to 150 Hz, but is higher during seizures and for higher frequencies. The Bidomain model has been used with success in modelling the electrical activity of the heart, but has been explored far less in the context of the brain. This study extends previous models of epileptic seizures on the neuronal level to the whole brain using the Bidomain model. Our approach is evaluated in terms of power-law distributions. The electric potentials were simulated in 7 idealized two-dimensional models and 3 three-dimensional patient-specific models derived from magnetic resonance images (MRI). Computed electric potentials were found to follow power-law distributions with slopes ranging from 2 to 5 for frequencies greater than 10-30 Hz." @default.
- W4282969069 created "2022-06-17" @default.
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- W4282969069 date "2022-06-16" @default.
- W4282969069 modified "2023-10-09" @default.
- W4282969069 title "Simulating epileptic seizures using the bidomain model" @default.
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- W4282969069 doi "https://doi.org/10.1038/s41598-022-12101-y" @default.
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