Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282973158> ?p ?o ?g. }
- W4282973158 endingPage "120721" @default.
- W4282973158 startingPage "120721" @default.
- W4282973158 abstract "Litter size reduction on the first days of life results in increased body weight and adiposity, with higher levels of circulating glucocorticoids. Obese rodents are more sensitive to the anabolic effects of glucocorticoids and less responsive to glucocorticoids feedback on hypothalamic-pituitary-adrenal (HPA) axis. This study aimed to evaluate effects of the treatment with corticosterone on metabolic responses and HPA axis in adult male rats reared in small litters.From postnatal day (PND) 60 to 88, adult male rats of normal (NL- 10 pups/dam) and small (SL- 3 pups/dam) litters received oral treatment with Corticosterone (CORT-15 mg/L) in the drinking water or no treatment, composing the four experimental groups (NL-water; NL-CORT; SL-water and SL-CORT), for the evaluation of energy homeostasis and HPA axis.Male rats of SL-water group presented on PND88: glucose intolerance, higher adiposity, plasma triglycerides, free fatty acids, total and low-density lipoprotein (LDL) cholesterol and corticosterone. SL-water animals showed increased mRNA of corticotrophin-releasing hormone (CRH) in the hypothalamic paraventricular nucleus (PVN) and proopiomelanocortin (POMC) in the pituitary, with decreased mRNA expression of PVN mineralocorticoid receptor. NL-CORT animals presented glucose intolerance, increased body weight, food intake, total and LDL cholesterol. Glucocorticoid treatment reduced corticosterone levels and adrenal cortex thickness in NL group, associated with increased mRNA of PVN CRH and pituitary POMC, without effects on SL animals.Lactation overnutrition promotes hyperreactivity of HPA axis and reduces the responsiveness to glucocorticoids effects on energy balance and negative feedback of HPA axis in adult male rats." @default.
- W4282973158 created "2022-06-17" @default.
- W4282973158 creator A5006671471 @default.
- W4282973158 creator A5007162207 @default.
- W4282973158 creator A5010212787 @default.
- W4282973158 creator A5021967574 @default.
- W4282973158 creator A5028656307 @default.
- W4282973158 creator A5032364136 @default.
- W4282973158 creator A5050907593 @default.
- W4282973158 creator A5073942392 @default.
- W4282973158 creator A5088268165 @default.
- W4282973158 creator A5091359000 @default.
- W4282973158 date "2022-09-01" @default.
- W4282973158 modified "2023-10-18" @default.
- W4282973158 title "Lactation overnutrition-induced obesity impairs effects of exogenous corticosterone on energy homeostasis and hypothalamic-pituitary-adrenal axis in male rats" @default.
- W4282973158 cites W123183545 @default.
- W4282973158 cites W177125011 @default.
- W4282973158 cites W1849085477 @default.
- W4282973158 cites W1971383287 @default.
- W4282973158 cites W1977944738 @default.
- W4282973158 cites W1982286481 @default.
- W4282973158 cites W1995343404 @default.
- W4282973158 cites W2004576893 @default.
- W4282973158 cites W2005344985 @default.
- W4282973158 cites W2019778386 @default.
- W4282973158 cites W2021726807 @default.
- W4282973158 cites W2028907433 @default.
- W4282973158 cites W2036704745 @default.
- W4282973158 cites W2051410584 @default.
- W4282973158 cites W2060644077 @default.
- W4282973158 cites W2079998168 @default.
- W4282973158 cites W2084912383 @default.
- W4282973158 cites W2095491277 @default.
- W4282973158 cites W2111330476 @default.
- W4282973158 cites W2111638230 @default.
- W4282973158 cites W2121568828 @default.
- W4282973158 cites W2128734278 @default.
- W4282973158 cites W2163509562 @default.
- W4282973158 cites W2166651133 @default.
- W4282973158 cites W2166857841 @default.
- W4282973158 cites W2167093292 @default.
- W4282973158 cites W2167384091 @default.
- W4282973158 cites W2169458819 @default.
- W4282973158 cites W2244806526 @default.
- W4282973158 cites W2337287253 @default.
- W4282973158 cites W2413555945 @default.
- W4282973158 cites W2556171273 @default.
- W4282973158 cites W2907251097 @default.
- W4282973158 cites W2923635651 @default.
- W4282973158 cites W2930803004 @default.
- W4282973158 cites W2952114048 @default.
- W4282973158 cites W4254913758 @default.
- W4282973158 doi "https://doi.org/10.1016/j.lfs.2022.120721" @default.
- W4282973158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35716735" @default.
- W4282973158 hasPublicationYear "2022" @default.
- W4282973158 type Work @default.
- W4282973158 citedByCount "1" @default.
- W4282973158 countsByYear W42829731582023 @default.
- W4282973158 crossrefType "journal-article" @default.
- W4282973158 hasAuthorship W4282973158A5006671471 @default.
- W4282973158 hasAuthorship W4282973158A5007162207 @default.
- W4282973158 hasAuthorship W4282973158A5010212787 @default.
- W4282973158 hasAuthorship W4282973158A5021967574 @default.
- W4282973158 hasAuthorship W4282973158A5028656307 @default.
- W4282973158 hasAuthorship W4282973158A5032364136 @default.
- W4282973158 hasAuthorship W4282973158A5050907593 @default.
- W4282973158 hasAuthorship W4282973158A5073942392 @default.
- W4282973158 hasAuthorship W4282973158A5088268165 @default.
- W4282973158 hasAuthorship W4282973158A5091359000 @default.
- W4282973158 hasConcept C126322002 @default.
- W4282973158 hasConcept C134018914 @default.
- W4282973158 hasConcept C2491326 @default.
- W4282973158 hasConcept C2777003273 @default.
- W4282973158 hasConcept C2778458438 @default.
- W4282973158 hasConcept C2779146795 @default.
- W4282973158 hasConcept C2780352252 @default.
- W4282973158 hasConcept C2780841215 @default.
- W4282973158 hasConcept C511355011 @default.
- W4282973158 hasConcept C71315377 @default.
- W4282973158 hasConcept C71924100 @default.
- W4282973158 hasConcept C86803240 @default.
- W4282973158 hasConceptScore W4282973158C126322002 @default.
- W4282973158 hasConceptScore W4282973158C134018914 @default.
- W4282973158 hasConceptScore W4282973158C2491326 @default.
- W4282973158 hasConceptScore W4282973158C2777003273 @default.
- W4282973158 hasConceptScore W4282973158C2778458438 @default.
- W4282973158 hasConceptScore W4282973158C2779146795 @default.
- W4282973158 hasConceptScore W4282973158C2780352252 @default.
- W4282973158 hasConceptScore W4282973158C2780841215 @default.
- W4282973158 hasConceptScore W4282973158C511355011 @default.
- W4282973158 hasConceptScore W4282973158C71315377 @default.
- W4282973158 hasConceptScore W4282973158C71924100 @default.
- W4282973158 hasConceptScore W4282973158C86803240 @default.
- W4282973158 hasLocation W42829731581 @default.
- W4282973158 hasLocation W42829731582 @default.
- W4282973158 hasOpenAccess W4282973158 @default.
- W4282973158 hasPrimaryLocation W42829731581 @default.
- W4282973158 hasRelatedWork W1986331805 @default.