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- W4282973704 abstract "Multiciliated cells (MCC) are evolutionary conserved, highly specialized cell types that contain dozens to hundreds of motile cilia that they use to propel fluid directionally. To template these cilia, each MCC produces between 30 and 500 basal bodies via a process termed centriole amplification. Much progress has been made in recent years in understanding the pathways involved in MCC fate determination, differentiation, and ciliogenesis. Recent studies using mammalian cell culture systems, mice, Xenopus, and other model organisms have started to uncover the mechanisms involved in centriole and cilia biogenesis. Yet, how MCC progenitor cells regulate the precise number of centrioles and cilia during their differentiation remains largely unknown. In this review, we will examine recent findings that address this fundamental question." @default.
- W4282973704 created "2022-06-17" @default.
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- W4282973704 date "2022-08-01" @default.
- W4282973704 modified "2023-09-29" @default.
- W4282973704 title "Development of a multiciliated cell" @default.
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- W4282973704 doi "https://doi.org/10.1016/j.ceb.2022.102105" @default.
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