FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282975612> ?p ?o ?g. }

• W4282975612 abstract "The parasite Trypanosoma brucei causes African sleeping sickness that is fatal to patients if untreated. Parasite differentiation from a replicative slender form into a quiescent stumpy form promotes host survival and parasite transmission. Long noncoding RNAs (lncRNAs) are known to regulate cell differentiation in other eukaryotes. To determine whether lncRNAs are also involved in parasite differentiation, we used RNA sequencing to survey the T. brucei genome, identifying 1428 previously uncharacterized lncRNA genes. We find that grumpy lncRNA is a key regulator that promotes parasite differentiation into the quiescent stumpy form. This function is promoted by a small nucleolar RNA encoded within the grumpy lncRNA. snoGRUMPY binds to messenger RNAs of at least two stumpy regulatory genes, promoting their expression. grumpy overexpression reduces parasitemia in infected mice. Our analyses suggest that T. brucei lncRNAs modulate parasite-host interactions and provide a mechanism by which grumpy regulates cell differentiation in trypanosomes." @default.
• W4282975612 created "2022-06-17" @default.
• W4282975612 creator A5006646678 @default.
• W4282975612 creator A5028872705 @default.
• W4282975612 creator A5029772844 @default.
• W4282975612 creator A5031040469 @default.
• W4282975612 creator A5036619595 @default.
• W4282975612 creator A5042121447 @default.
• W4282975612 creator A5042571199 @default.
• W4282975612 creator A5056279786 @default.
• W4282975612 creator A5058332830 @default.
• W4282975612 creator A5075252986 @default.
• W4282975612 creator A5075837228 @default.
• W4282975612 creator A5079904690 @default.
• W4282975612 creator A5082888270 @default.
• W4282975612 creator A5084967116 @default.
• W4282975612 creator A5087255793 @default.
• W4282975612 date "2022-06-17" @default.
• W4282975612 modified "2023-10-18" @default.
• W4282975612 title "A long noncoding RNA promotes parasite differentiation in African trypanosomes" @default.
• W4282975612 cites W104136475 @default.
• W4282975612 cites W1503377827 @default.
• W4282975612 cites W1973767731 @default.
• W4282975612 cites W1976459963 @default.
• W4282975612 cites W1976776701 @default.
• W4282975612 cites W1985557583 @default.
• W4282975612 cites W2001197674 @default.
• W4282975612 cites W2003553455 @default.
• W4282975612 cites W2034383160 @default.
• W4282975612 cites W2036897871 @default.
• W4282975612 cites W2043841998 @default.
• W4282975612 cites W2055043387 @default.
• W4282975612 cites W2058615001 @default.
• W4282975612 cites W2063205329 @default.
• W4282975612 cites W2074701664 @default.
• W4282975612 cites W2080752012 @default.
• W4282975612 cites W2089351045 @default.
• W4282975612 cites W2093404711 @default.
• W4282975612 cites W2093822146 @default.
• W4282975612 cites W2095256515 @default.
• W4282975612 cites W2099591523 @default.
• W4282975612 cites W2103441770 @default.
• W4282975612 cites W2103874817 @default.
• W4282975612 cites W2105349784 @default.
• W4282975612 cites W2109700867 @default.
• W4282975612 cites W2112321215 @default.
• W4282975612 cites W2114091126 @default.
• W4282975612 cites W2116350092 @default.
• W4282975612 cites W2123139638 @default.
• W4282975612 cites W2123210059 @default.
• W4282975612 cites W2125022130 @default.
• W4282975612 cites W2137586531 @default.
• W4282975612 cites W2152645648 @default.
• W4282975612 cites W2153023888 @default.
• W4282975612 cites W2156559790 @default.
• W4282975612 cites W2157107905 @default.
• W4282975612 cites W2158427156 @default.
• W4282975612 cites W2162758337 @default.
• W4282975612 cites W2163473231 @default.
• W4282975612 cites W2171143303 @default.
• W4282975612 cites W2259938310 @default.
• W4282975612 cites W2281680465 @default.
• W4282975612 cites W2338889021 @default.
• W4282975612 cites W2345999730 @default.
• W4282975612 cites W2363081453 @default.
• W4282975612 cites W2399029136 @default.
• W4282975612 cites W2481299664 @default.
• W4282975612 cites W2514258009 @default.
• W4282975612 cites W2528660759 @default.
• W4282975612 cites W2593479908 @default.
• W4282975612 cites W2597131514 @default.
• W4282975612 cites W2615786037 @default.
• W4282975612 cites W2734292862 @default.
• W4282975612 cites W2750876973 @default.
• W4282975612 cites W2769011958 @default.
• W4282975612 cites W2789843538 @default.
• W4282975612 cites W2809918388 @default.
• W4282975612 cites W2895607350 @default.
• W4282975612 cites W2903926301 @default.
• W4282975612 cites W2918407275 @default.
• W4282975612 cites W2943588752 @default.
• W4282975612 cites W2947963640 @default.
• W4282975612 cites W2964973973 @default.
• W4282975612 cites W2969302517 @default.
• W4282975612 cites W2989499631 @default.
• W4282975612 cites W3014228495 @default.
• W4282975612 cites W3014232414 @default.
• W4282975612 cites W3018251988 @default.
• W4282975612 cites W3097320691 @default.
• W4282975612 cites W3115880421 @default.
• W4282975612 cites W3120085474 @default.
• W4282975612 cites W3205926432 @default.
• W4282975612 cites W4221019092 @default.
• W4282975612 cites W4252834064 @default.
• W4282975612 cites W70041852 @default.
• W4282975612 doi "https://doi.org/10.1126/sciadv.abn2706" @default.
• W4282975612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35704590" @default.
• W4282975612 hasPublicationYear "2022" @default.
• W4282975612 type Work @default.
• W4282975612 citedByCount "10" @default.

• next