FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282976727> ?p ?o ?g. }

• W4282976727 abstract "MicroRNAs (MiRNAs) are known to participate in preadipocyte differentiation, but the manner in which miR-146a-5p participates in this process remains unclear. This study was performed to examine the participation of miR-146a-5p in 3T3-L1 cell differentiation.miR-146a-5p expression was upregulated and down-regulated to examine effects on 3T3-L1 cell differentiation. Bioinformatics analysis was performed to predict its target genes, and the signaling pathway it regulates was identified by qRT-PCR and Western blotting. The expression of miR-146a-5p in epididymal adipose tissue from obese mice and in an obese mouse adipose cell model was examined by qRT-PCR.3T3-L1 cells differentiated into mature adipocytes successfully, as verified by increased areas of intracellular lipid droplets and elevated expression of mature adipocyte markers, and these cells had elevated miR-146a-5p expression. The intracellular lipid droplet and triglyceride contents and the expression of mature adipocyte markers were significantly increased in miR-146a-5p-overexpressing 3T3-L1 cells and markedly decreased in miR-146a-5p-inhibited 3T3-L1 cells. ErbB4 was a predicted target gene of miR-146a-5p. In miR-146a-5p-overexpressing 3T3-L1 cells, ErbB4 expression and ERK1/2 phosphorylation were decreased and the expression of PPAR-γ was increased; the opposite was observed in miR-146a-5p-inhibited 3T3-L1 cells. In addition, miR-146a-5p expression was significantly increased in the mouse epididymal adipose tissue and adipose cell model.Upregulated miR-146a-5p expression was related to 3T3-L1 cell differentiation. MiR-146a-5p promoted 3T3-L1 cell differentiation by targeting ErbB4 and via the ERK1/2/PPAR-γ signaling pathway." @default.
• W4282976727 created "2022-06-17" @default.
• W4282976727 creator A5012752526 @default.
• W4282976727 creator A5050289410 @default.
• W4282976727 creator A5053008794 @default.
• W4282976727 creator A5056311862 @default.
• W4282976727 creator A5061114195 @default.
• W4282976727 creator A5090600960 @default.
• W4282976727 date "2022-06-15" @default.
• W4282976727 modified "2023-10-17" @default.
• W4282976727 title "MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway" @default.
• W4282976727 cites W1546868324 @default.
• W4282976727 cites W1572518524 @default.
• W4282976727 cites W1780918613 @default.
• W4282976727 cites W1907219612 @default.
• W4282976727 cites W1975998449 @default.
• W4282976727 cites W1981332939 @default.
• W4282976727 cites W1982810858 @default.
• W4282976727 cites W2016701686 @default.
• W4282976727 cites W2019141607 @default.
• W4282976727 cites W2025029856 @default.
• W4282976727 cites W2031944234 @default.
• W4282976727 cites W2093856697 @default.
• W4282976727 cites W2098285533 @default.
• W4282976727 cites W2116726599 @default.
• W4282976727 cites W2123206362 @default.
• W4282976727 cites W2130596514 @default.
• W4282976727 cites W2166094946 @default.
• W4282976727 cites W2212051246 @default.
• W4282976727 cites W2268685530 @default.
• W4282976727 cites W2284659436 @default.
• W4282976727 cites W2397243787 @default.
• W4282976727 cites W2402511072 @default.
• W4282976727 cites W2574062068 @default.
• W4282976727 cites W2593570718 @default.
• W4282976727 cites W2735376054 @default.
• W4282976727 cites W2788658193 @default.
• W4282976727 cites W2790735034 @default.
• W4282976727 cites W2794544623 @default.
• W4282976727 cites W2810036321 @default.
• W4282976727 cites W2886880537 @default.
• W4282976727 cites W2905188402 @default.
• W4282976727 cites W2908617306 @default.
• W4282976727 cites W2912786033 @default.
• W4282976727 cites W2913202413 @default.
• W4282976727 cites W2914315230 @default.
• W4282976727 cites W2937917611 @default.
• W4282976727 cites W2944549000 @default.
• W4282976727 cites W2946333265 @default.
• W4282976727 cites W2947432735 @default.
• W4282976727 cites W2970300251 @default.
• W4282976727 cites W3013624372 @default.
• W4282976727 cites W3016392911 @default.
• W4282976727 cites W3026172159 @default.
• W4282976727 cites W3128998005 @default.
• W4282976727 doi "https://doi.org/10.1186/s12944-022-01662-6" @default.
• W4282976727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35705996" @default.
• W4282976727 hasPublicationYear "2022" @default.
• W4282976727 type Work @default.
• W4282976727 citedByCount "2" @default.
• W4282976727 countsByYear W42829767272023 @default.
• W4282976727 crossrefType "journal-article" @default.
• W4282976727 hasAuthorship W4282976727A5012752526 @default.
• W4282976727 hasAuthorship W4282976727A5050289410 @default.
• W4282976727 hasAuthorship W4282976727A5053008794 @default.
• W4282976727 hasAuthorship W4282976727A5056311862 @default.
• W4282976727 hasAuthorship W4282976727A5061114195 @default.
• W4282976727 hasAuthorship W4282976727A5090600960 @default.
• W4282976727 hasBestOaLocation W42829767271 @default.
• W4282976727 hasConcept C104317684 @default.
• W4282976727 hasConcept C122927707 @default.
• W4282976727 hasConcept C126322002 @default.
• W4282976727 hasConcept C127561419 @default.
• W4282976727 hasConcept C134018914 @default.
• W4282976727 hasConcept C142536801 @default.
• W4282976727 hasConcept C145059251 @default.
• W4282976727 hasConcept C148738053 @default.
• W4282976727 hasConcept C1491633281 @default.
• W4282976727 hasConcept C171089720 @default.
• W4282976727 hasConcept C25095133 @default.
• W4282976727 hasConcept C2776175234 @default.
• W4282976727 hasConcept C2781018059 @default.
• W4282976727 hasConcept C29537977 @default.
• W4282976727 hasConcept C55493867 @default.
• W4282976727 hasConcept C71924100 @default.
• W4282976727 hasConcept C86803240 @default.
• W4282976727 hasConcept C95444343 @default.
• W4282976727 hasConceptScore W4282976727C104317684 @default.
• W4282976727 hasConceptScore W4282976727C122927707 @default.
• W4282976727 hasConceptScore W4282976727C126322002 @default.
• W4282976727 hasConceptScore W4282976727C127561419 @default.
• W4282976727 hasConceptScore W4282976727C134018914 @default.
• W4282976727 hasConceptScore W4282976727C142536801 @default.
• W4282976727 hasConceptScore W4282976727C145059251 @default.
• W4282976727 hasConceptScore W4282976727C148738053 @default.
• W4282976727 hasConceptScore W4282976727C1491633281 @default.
• W4282976727 hasConceptScore W4282976727C171089720 @default.
• W4282976727 hasConceptScore W4282976727C25095133 @default.
• W4282976727 hasConceptScore W4282976727C2776175234 @default.
• W4282976727 hasConceptScore W4282976727C2781018059 @default.

• next