Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282982170> ?p ?o ?g. }
- W4282982170 abstract "ABSTRACT Motile cilia generate cell propulsion and extracellular fluid flows that are crucial for airway clearance, fertility and left-right patterning. Motility is powered by dynein arm complexes that are assembled in the cytoplasm then imported into the cilium. Studies in Chlamydomonas reinhardtii showed that ODA16 is a cofactor which promotes dynein arm import. Here, we demonstrate that the zebrafish homolog of ODA16, Daw1, facilitates the onset of robust cilia motility during development. Without Daw1, cilia showed markedly reduced motility during early development; however, motility subsequently increased to attain close to wild-type levels. Delayed motility onset led to differential effects on early and late cilia-dependent processes. Remarkably, abnormal body axis curves, which formed during the first day of development due to reduced cilia motility, self-corrected when motility later reached wild-type levels. Zebrafish larva therefore possess the ability to survey and correct body shape abnormalities. This work defines Daw1 as a factor which promotes the onset of timely cilia motility and can explain why human patients harboring DAW1 mutations exhibit significant laterality perturbations but mild airway and fertility complications." @default.
- W4282982170 created "2022-06-17" @default.
- W4282982170 creator A5034235673 @default.
- W4282982170 creator A5045211106 @default.
- W4282982170 creator A5045859023 @default.
- W4282982170 creator A5046298931 @default.
- W4282982170 creator A5067255047 @default.
- W4282982170 creator A5078259766 @default.
- W4282982170 creator A5091628067 @default.
- W4282982170 creator A5091846963 @default.
- W4282982170 date "2022-06-15" @default.
- W4282982170 modified "2023-10-14" @default.
- W4282982170 title "Daw1 regulates the timely onset of cilia motility during development" @default.
- W4282982170 cites W1809267070 @default.
- W4282982170 cites W1915704240 @default.
- W4282982170 cites W1983831423 @default.
- W4282982170 cites W1987279648 @default.
- W4282982170 cites W2016262076 @default.
- W4282982170 cites W2017068376 @default.
- W4282982170 cites W2017224987 @default.
- W4282982170 cites W2025073905 @default.
- W4282982170 cites W2030939638 @default.
- W4282982170 cites W2039498015 @default.
- W4282982170 cites W2041085963 @default.
- W4282982170 cites W2053768951 @default.
- W4282982170 cites W2058525645 @default.
- W4282982170 cites W2069089843 @default.
- W4282982170 cites W2109822773 @default.
- W4282982170 cites W2117634438 @default.
- W4282982170 cites W2167279371 @default.
- W4282982170 cites W2278997980 @default.
- W4282982170 cites W2416325988 @default.
- W4282982170 cites W2461942481 @default.
- W4282982170 cites W2514995173 @default.
- W4282982170 cites W2585610501 @default.
- W4282982170 cites W2593296415 @default.
- W4282982170 cites W2602325707 @default.
- W4282982170 cites W2606745140 @default.
- W4282982170 cites W2735207367 @default.
- W4282982170 cites W2735570916 @default.
- W4282982170 cites W2752837578 @default.
- W4282982170 cites W2794487108 @default.
- W4282982170 cites W2805068795 @default.
- W4282982170 cites W2810058136 @default.
- W4282982170 cites W2883339193 @default.
- W4282982170 cites W2888151186 @default.
- W4282982170 cites W2898810121 @default.
- W4282982170 cites W2901630657 @default.
- W4282982170 cites W2908047046 @default.
- W4282982170 cites W2951506174 @default.
- W4282982170 cites W2989923168 @default.
- W4282982170 cites W2998970366 @default.
- W4282982170 cites W3014767585 @default.
- W4282982170 cites W3016857842 @default.
- W4282982170 cites W3022979658 @default.
- W4282982170 cites W3036246898 @default.
- W4282982170 cites W3042237238 @default.
- W4282982170 cites W3095432680 @default.
- W4282982170 cites W3095668021 @default.
- W4282982170 cites W3104572769 @default.
- W4282982170 cites W4211135382 @default.
- W4282982170 doi "https://doi.org/10.1242/dev.200017" @default.
- W4282982170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35708608" @default.
- W4282982170 hasPublicationYear "2022" @default.
- W4282982170 type Work @default.
- W4282982170 citedByCount "5" @default.
- W4282982170 countsByYear W42829821702022 @default.
- W4282982170 countsByYear W42829821702023 @default.
- W4282982170 crossrefType "journal-article" @default.
- W4282982170 hasAuthorship W4282982170A5034235673 @default.
- W4282982170 hasAuthorship W4282982170A5045211106 @default.
- W4282982170 hasAuthorship W4282982170A5045859023 @default.
- W4282982170 hasAuthorship W4282982170A5046298931 @default.
- W4282982170 hasAuthorship W4282982170A5067255047 @default.
- W4282982170 hasAuthorship W4282982170A5078259766 @default.
- W4282982170 hasAuthorship W4282982170A5091628067 @default.
- W4282982170 hasAuthorship W4282982170A5091846963 @default.
- W4282982170 hasBestOaLocation W42829821701 @default.
- W4282982170 hasConcept C100094513 @default.
- W4282982170 hasConcept C104317684 @default.
- W4282982170 hasConcept C106987784 @default.
- W4282982170 hasConcept C115811362 @default.
- W4282982170 hasConcept C195267511 @default.
- W4282982170 hasConcept C20418707 @default.
- W4282982170 hasConcept C24870808 @default.
- W4282982170 hasConcept C2776878037 @default.
- W4282982170 hasConcept C2777632594 @default.
- W4282982170 hasConcept C2910722709 @default.
- W4282982170 hasConcept C54355233 @default.
- W4282982170 hasConcept C58207958 @default.
- W4282982170 hasConcept C86803240 @default.
- W4282982170 hasConcept C95444343 @default.
- W4282982170 hasConceptScore W4282982170C100094513 @default.
- W4282982170 hasConceptScore W4282982170C104317684 @default.
- W4282982170 hasConceptScore W4282982170C106987784 @default.
- W4282982170 hasConceptScore W4282982170C115811362 @default.
- W4282982170 hasConceptScore W4282982170C195267511 @default.
- W4282982170 hasConceptScore W4282982170C20418707 @default.
- W4282982170 hasConceptScore W4282982170C24870808 @default.
- W4282982170 hasConceptScore W4282982170C2776878037 @default.