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- W4283008833 abstract "Objective: Pulse contour cardiac output (CO) monitoring systems have provided less invasive methods for estimating CO using arterial blood pressure (ABP) waveforms. The accuracy of these CO monitoring systems is assessed through clinical trials by comparing device measurements with those from a reference thermodilution method. However, evaluating other characteristics of CO monitoring systems including time response, CO resolution, and stroke volume variation (SVV) resolution through clinical trials and animal models are invasive, or not practical due to the limitations of the thermodilution method and clinical studies. Here, we present a mock circulatory loop (MCL) for evaluating key characteristics of the CO monitoring systems. Methods: We developed an MCL (Fig. 1A) with peripheral radial components and a programmable gear pump capable of generating high resolution flow/pressure conditions. The MCL can reproducibly simulate different hemodynamic states and enables beat-to-beat control over the morphology of pressure/flow waveforms. The MCL was configured to simulate a normovolemic state and assessed for stability of pressure/flow waveforms over time, aortic-to-radial pressure relationship (transfer function), and repeatability. Results: The MCL was tuned to simulate average hemodynamics of the normovolemic population (Fig. 1B). The aortic-to-radial pressure transfer function of the MCL was comparable to those reported in the literature within the frequency range of 0 to ~3.3Hz, where 98% of ascending aortic and radial pressure pulse power is contained within (shaded area in Fig. 1C). The MCL maintained beat-to-beat stability and repeatability over the test duration (CO (L/min): 5.3±0.12, and mean ABP (mmHg): 109±0.2). Conclusions: Here, we assessed the performance of an MCL that could be used in a bench testing framework to evaluate different characteristics of pulse contour CO monitoring systems. The system provides beat-to-beat controllability that is required for time response, CO and SVV resolution tests. Disclaimer: The mention of commercial products, their sources, or their use in connection with material reported herein is not to be construed as either an actual or implied endorsement of such products by the Department of Health and Human Services. This article reflects the views of the authors and should not be construed to represent FDA’s views or policies." @default.
- W4283008833 created "2022-06-18" @default.
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- W4283008833 date "2022-06-01" @default.
- W4283008833 modified "2023-09-26" @default.
- W4283008833 title "P76: Simulating aortic flow and radial pressure waveforms using a mock circulatory loop for testing pulse contour cardiac output monitoring systems" @default.
- W4283008833 doi "https://doi.org/10.1097/01.mat.0000841520.68137.31" @default.
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