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- W4283011229 endingPage "605" @default.
- W4283011229 startingPage "589" @default.
- W4283011229 abstract "Bone marrow adipose tissues (BMATs) and their main cellular component, bone marrow adipocytes (BMAds), are found within the bone marrow (BM), which is a niche for the development of hematological malignancies as well as bone metastasis from solid tumors such as breast and prostate cancers. In humans, BMAds are present within the hematopoietic or red BMAT and in the yellow BMAT where they are more densely packed. BMAds are emerging as new actors in tumor progression; however, there are many outstanding questions regarding their precise role. In this review, we summarized our current knowledge regarding the development, distribution, and regulation by external stimuli of the BMATs in mice and humans and addressed how obesity could affect these traits. We then discussed the specific metabolic phenotype of BMAds that appear to be different from classical white adipocytes, since they are devoid of lipolytic function. According to this characterization, we presented how tumor cells affect the in vitro and in vivo phenotype of BMAds and the signals emanating from BMAds that are susceptible to modulate tumor behavior with a specific emphasis on their metabolic crosstalk with cancer cells. Finally, we discussed how obesity could affect this crosstalk. Deciphering the role of BMAds in tumor progression would certainly lead to the identification of new targets in oncology in the near future." @default.
- W4283011229 created "2022-06-18" @default.
- W4283011229 creator A5025135656 @default.
- W4283011229 creator A5057718660 @default.
- W4283011229 creator A5067815543 @default.
- W4283011229 creator A5076644154 @default.
- W4283011229 date "2022-06-16" @default.
- W4283011229 modified "2023-10-11" @default.
- W4283011229 title "The role of bone marrow adipocytes in cancer progression: the impact of obesity" @default.
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