FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283013453> ?p ?o ?g. }

• W4283013453 endingPage "86" @default.
• W4283013453 startingPage "81" @default.
• W4283013453 abstract "Cell therapy is a promising alternative treatment approach currently under study for osteoarthritis (OA), the most common chronic musculoskeletal disease. However, the mesenchymal stem cells (MSCs) used in cell therapy to treat OA are usually expanded in vitro to obtain sufficient numbers for transplantation, and their safety has not been fully assessed from multiple perspectives. Analysis of karyotypic abnormalities, in particular, is important to ensure the safety of cells; however, chromosomal mutations may also occur during the cell-expansion process. In addition, there have been many reports showing chromosome abnormalities, mainly trisomy 7, in the cartilage and synovium of patients with OA as well as in normal tissues. The suitability of cells with these karyotypic abnormalities as cells for cell therapy has not been evaluated. Recently, we assessed the safety of using cells with trisomy 7 from the osteoarthritic joint of a patient for transplantation, and we followed up with the patient for 5 years. This study showed analysis for copy number variant and whole-genome sequencing, compared with blood DNA from the same patient. We did not find any abnormalities in the genes regardless of trisomy 7. No side effects were observed for at least 5 years in the human clinical study. This suggests that the transplantation of cultured cells with trisomy 7 isolated from an osteoarthritic joint and transplanted into the osteoarthritic joints of the same person is not expected to cause serious adverse events. However, it is unclear what problems may arise in the case of allogeneic transplantation. Different types of risks will also exist depending on other transplantation routes, such as localization to the knee-joint only or circulation inflow and lung entrapment. In addition, since the cause of trisomy 7 occurrence remains unclear, it is necessary to clarify the mechanism of trisomy 7 in OA to perform cell therapy for OA patients in a safe manner." @default.
• W4283013453 created "2022-06-18" @default.
• W4283013453 creator A5039180718 @default.
• W4283013453 creator A5057511781 @default.
• W4283013453 creator A5068969088 @default.
• W4283013453 date "2022-12-01" @default.
• W4283013453 modified "2023-09-29" @default.
• W4283013453 title "Safety of using cultured cells with trisomy 7 in cell therapy for treating osteoarthritis" @default.
• W4283013453 cites W1967684815 @default.
• W4283013453 cites W1976828590 @default.
• W4283013453 cites W1978351945 @default.
• W4283013453 cites W1981311870 @default.
• W4283013453 cites W1996972223 @default.
• W4283013453 cites W2000628323 @default.
• W4283013453 cites W2008721567 @default.
• W4283013453 cites W2008990603 @default.
• W4283013453 cites W2010620515 @default.
• W4283013453 cites W2018648995 @default.
• W4283013453 cites W2030457606 @default.
• W4283013453 cites W2032647229 @default.
• W4283013453 cites W2046674871 @default.
• W4283013453 cites W2047328992 @default.
• W4283013453 cites W2049802626 @default.
• W4283013453 cites W2051893135 @default.
• W4283013453 cites W2059070156 @default.
• W4283013453 cites W2063070261 @default.
• W4283013453 cites W2081829830 @default.
• W4283013453 cites W2084914185 @default.
• W4283013453 cites W2091803112 @default.
• W4283013453 cites W2094022717 @default.
• W4283013453 cites W2094044265 @default.
• W4283013453 cites W2104316705 @default.
• W4283013453 cites W2109268637 @default.
• W4283013453 cites W2115284537 @default.
• W4283013453 cites W2115324900 @default.
• W4283013453 cites W2118146052 @default.
• W4283013453 cites W2120104265 @default.
• W4283013453 cites W2123019826 @default.
• W4283013453 cites W2136982551 @default.
• W4283013453 cites W2140115841 @default.
• W4283013453 cites W2141391981 @default.
• W4283013453 cites W2146429076 @default.
• W4283013453 cites W2158780936 @default.
• W4283013453 cites W2174039816 @default.
• W4283013453 cites W2232950207 @default.
• W4283013453 cites W2238465256 @default.
• W4283013453 cites W2256958843 @default.
• W4283013453 cites W2309051064 @default.
• W4283013453 cites W2333262620 @default.
• W4283013453 cites W2340484500 @default.
• W4283013453 cites W2395903840 @default.
• W4283013453 cites W2586232176 @default.
• W4283013453 cites W2765490946 @default.
• W4283013453 cites W2800091981 @default.
• W4283013453 cites W2804865700 @default.
• W4283013453 cites W2902401105 @default.
• W4283013453 cites W2956415166 @default.
• W4283013453 cites W2957619314 @default.
• W4283013453 cites W2985612751 @default.
• W4283013453 cites W3047351870 @default.
• W4283013453 cites W3049201850 @default.
• W4283013453 cites W3086979901 @default.
• W4283013453 cites W3089040287 @default.
• W4283013453 cites W3167779616 @default.
• W4283013453 cites W3177518581 @default.
• W4283013453 cites W3189360279 @default.
• W4283013453 cites W4245895550 @default.
• W4283013453 doi "https://doi.org/10.1016/j.reth.2022.06.003" @default.
• W4283013453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35785042" @default.
• W4283013453 hasPublicationYear "2022" @default.
• W4283013453 type Work @default.
• W4283013453 citedByCount "3" @default.
• W4283013453 countsByYear W42830134532022 @default.
• W4283013453 countsByYear W42830134532023 @default.
• W4283013453 crossrefType "journal-article" @default.
• W4283013453 hasAuthorship W4283013453A5039180718 @default.
• W4283013453 hasAuthorship W4283013453A5057511781 @default.
• W4283013453 hasAuthorship W4283013453A5068969088 @default.
• W4283013453 hasBestOaLocation W42830134533 @default.
• W4283013453 hasConcept C10882517 @default.
• W4283013453 hasConcept C126322002 @default.
• W4283013453 hasConcept C142724271 @default.
• W4283013453 hasConcept C198826908 @default.
• W4283013453 hasConcept C204787440 @default.
• W4283013453 hasConcept C2776164576 @default.
• W4283013453 hasConcept C2776229224 @default.
• W4283013453 hasConcept C28328180 @default.
• W4283013453 hasConcept C2911091166 @default.
• W4283013453 hasConcept C502942594 @default.
• W4283013453 hasConcept C54355233 @default.
• W4283013453 hasConcept C60644358 @default.
• W4283013453 hasConcept C71924100 @default.
• W4283013453 hasConcept C86803240 @default.
• W4283013453 hasConceptScore W4283013453C10882517 @default.
• W4283013453 hasConceptScore W4283013453C126322002 @default.
• W4283013453 hasConceptScore W4283013453C142724271 @default.
• W4283013453 hasConceptScore W4283013453C198826908 @default.
• W4283013453 hasConceptScore W4283013453C204787440 @default.

• next