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- W4283013977 endingPage "114394" @default.
- W4283013977 startingPage "114394" @default.
- W4283013977 abstract "Cell-based drug delivery systems (DDSs) have received attention recently because of their unique biological properties and self-powered functions, such as excellent biocompatibility, low immunogenicity, long circulation time, tissue-homingcharacteristics, and ability to cross biological barriers. A variety of cells, including erythrocytes, stem cells, and lymphocytes, have been explored as functional vectors for the loading and delivery of various therapeutic payloads (e.g., small-molecule and nucleic acid drugs) for subsequent disease treatment. These cell-based DDSs have their own unique in vivo fates, which are attributed to various factors, including their biological properties and functions, the loaded drugs and loading process, physiological and pathological circumstances, and the body's response to these carrier cells, which result in differences in drug delivery efficiency and therapeutic effect. In this review, we summarize the main cell-based DDSs and their biological properties and functions, applications in drug delivery and disease treatment, and in vivo fate and influencing factors. We envision that the unique biological properties, combined with continuing research, will enable development of cell-based DDSs as friendly drug vectors for the safe, effective, and even personalized treatment of diseases." @default.
- W4283013977 created "2022-06-18" @default.
- W4283013977 creator A5020819058 @default.
- W4283013977 creator A5029737609 @default.
- W4283013977 creator A5043917554 @default.
- W4283013977 creator A5047997811 @default.
- W4283013977 creator A5049692788 @default.
- W4283013977 date "2022-08-01" @default.
- W4283013977 modified "2023-10-16" @default.
- W4283013977 title "Cell-based drug delivery systems and their in vivo fate" @default.
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