FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283018044> ?p ?o ?g. }

• W4283018044 abstract "The moderate activation of T cells in mammals requires the costimulatory molecules, CD80 and CD86, on antigen-presenting cells to interact with their respective T cell receptors, CD28 and CD152 (CTLA-4), to promote costimulatory signals. In contrast, teleost fish (except salmonids) only possess CD80/86 as their sole primordial costimulatory molecule. However, the mechanism, which underlies the interaction between CD80/86 and its receptors CD28 and CD152 still requires elucidation. In this study, we cloned and identified the CD80/86, CD28, and CD152 genes of the grass carp (Ctenopharyngodon idella). The mRNA expression analysis showed that CD80/86, CD28, and CD152 were constitutively expressed in various tissues. Further analysis revealed that CD80/86 was highly expressed in IgM+ B cells. Conversely, CD28 and CD152 were highly expressed in CD4+ and CD8+ T cells. Subcellular localization illustrated that CD80/86, CD28, and CD152 are all located on the cell membrane. A yeast two-hybrid assay exhibited that CD80/86 can bind with both CD28 and CD152. In vivo assay showed that the expression of CD80/86 was rapidly upregulated in Aeromonas hydrophila infected fish compared to the control fish. However, the expression of CD28 and CD152 presented the inverse trend, suggesting that teleost fish may regulate T cell activation through the differential expression of CD28 and CD152. Importantly, we discovered that T cells were more likely to be activated by A. hydrophila after CD152 was blocked by anti-CD152 antibodies. This suggests that the teleost CD152 is an inhibitory receptor of T cell activation, which is similar to the mammalian CD152. Overall, this study begins to define the interaction feature between primordial CD80/86 and its receptors CD28 and CD152 in teleost fish, alongside providing a cross-species understanding of the evolution of the costimulatory signals throughout vertebrates." @default.
• W4283018044 created "2022-06-18" @default.
• W4283018044 creator A5002252254 @default.
• W4283018044 creator A5003642180 @default.
• W4283018044 creator A5004500525 @default.
• W4283018044 creator A5015337633 @default.
• W4283018044 creator A5033628878 @default.
• W4283018044 creator A5057277593 @default.
• W4283018044 creator A5075140744 @default.
• W4283018044 date "2022-06-16" @default.
• W4283018044 modified "2023-10-17" @default.
• W4283018044 title "Molecular and Functional Analyses of the Primordial Costimulatory Molecule CD80/86 and Its Receptors CD28 and CD152 (CTLA-4) in a Teleost Fish" @default.
• W4283018044 cites W1489480103 @default.
• W4283018044 cites W1543514149 @default.
• W4283018044 cites W1963861811 @default.
• W4283018044 cites W1969979294 @default.
• W4283018044 cites W1974381902 @default.
• W4283018044 cites W1975322648 @default.
• W4283018044 cites W2002778633 @default.
• W4283018044 cites W2008768526 @default.
• W4283018044 cites W2017281498 @default.
• W4283018044 cites W2021211970 @default.
• W4283018044 cites W2029175700 @default.
• W4283018044 cites W2034087823 @default.
• W4283018044 cites W2043326465 @default.
• W4283018044 cites W2046739604 @default.
• W4283018044 cites W2058406709 @default.
• W4283018044 cites W2072918899 @default.
• W4283018044 cites W2076258597 @default.
• W4283018044 cites W2086113459 @default.
• W4283018044 cites W2097230664 @default.
• W4283018044 cites W2101672858 @default.
• W4283018044 cites W2121498145 @default.
• W4283018044 cites W2128211447 @default.
• W4283018044 cites W2137813497 @default.
• W4283018044 cites W2149748445 @default.
• W4283018044 cites W2153185719 @default.
• W4283018044 cites W2154938671 @default.
• W4283018044 cites W2167096139 @default.
• W4283018044 cites W2253000935 @default.
• W4283018044 cites W2346835696 @default.
• W4283018044 cites W2483753885 @default.
• W4283018044 cites W2491666359 @default.
• W4283018044 cites W2560778673 @default.
• W4283018044 cites W2611301610 @default.
• W4283018044 cites W2620593030 @default.
• W4283018044 cites W2766334561 @default.
• W4283018044 cites W2766869398 @default.
• W4283018044 cites W2807489812 @default.
• W4283018044 cites W2847073070 @default.
• W4283018044 cites W2887811656 @default.
• W4283018044 cites W2897698729 @default.
• W4283018044 cites W2904469027 @default.
• W4283018044 cites W2957722758 @default.
• W4283018044 cites W2989873750 @default.
• W4283018044 cites W2999749404 @default.
• W4283018044 cites W3018134278 @default.
• W4283018044 cites W3112482910 @default.
• W4283018044 cites W3212885582 @default.
• W4283018044 cites W4205277423 @default.
• W4283018044 cites W4223629051 @default.
• W4283018044 doi "https://doi.org/10.3389/fimmu.2022.885005" @default.
• W4283018044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35784316" @default.
• W4283018044 hasPublicationYear "2022" @default.
• W4283018044 type Work @default.
• W4283018044 citedByCount "2" @default.
• W4283018044 countsByYear W42830180442022 @default.
• W4283018044 countsByYear W42830180442023 @default.
• W4283018044 crossrefType "journal-article" @default.
• W4283018044 hasAuthorship W4283018044A5002252254 @default.
• W4283018044 hasAuthorship W4283018044A5003642180 @default.
• W4283018044 hasAuthorship W4283018044A5004500525 @default.
• W4283018044 hasAuthorship W4283018044A5015337633 @default.
• W4283018044 hasAuthorship W4283018044A5033628878 @default.
• W4283018044 hasAuthorship W4283018044A5057277593 @default.
• W4283018044 hasAuthorship W4283018044A5075140744 @default.
• W4283018044 hasBestOaLocation W42830180441 @default.
• W4283018044 hasConcept C148125776 @default.
• W4283018044 hasConcept C153911025 @default.
• W4283018044 hasConcept C154317977 @default.
• W4283018044 hasConcept C170493617 @default.
• W4283018044 hasConcept C202751555 @default.
• W4283018044 hasConcept C203014093 @default.
• W4283018044 hasConcept C2776090121 @default.
• W4283018044 hasConcept C2778297330 @default.
• W4283018044 hasConcept C2778297628 @default.
• W4283018044 hasConcept C2781101188 @default.
• W4283018044 hasConcept C2781403440 @default.
• W4283018044 hasConcept C39347974 @default.
• W4283018044 hasConcept C505870484 @default.
• W4283018044 hasConcept C55493867 @default.
• W4283018044 hasConcept C86803240 @default.
• W4283018044 hasConcept C8891405 @default.
• W4283018044 hasConcept C95444343 @default.
• W4283018044 hasConceptScore W4283018044C148125776 @default.
• W4283018044 hasConceptScore W4283018044C153911025 @default.
• W4283018044 hasConceptScore W4283018044C154317977 @default.
• W4283018044 hasConceptScore W4283018044C170493617 @default.
• W4283018044 hasConceptScore W4283018044C202751555 @default.
• W4283018044 hasConceptScore W4283018044C203014093 @default.

• next