FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283018236> ?p ?o ?g. }

• W4283018236 abstract "Abstract Background Leishmaniasis is a neglected infectious disease caused by protozoa of the genus Leishmania . The disease generally manifests as characteristic skin lesions which require lengthy treatment with antimonial drugs that are often associated with adverse side effects. Therefore, a number of studies have focused on natural compounds as promising drugs for its treatment. This study aimed to evaluate the effects of larval excretion/secretion products (ES) of Lucilia sericata in crude and fractionated forms on Leishmania major , by using in vitro and in vivo models. Methods The in vitro experiments involved evaluation of ES on both promastigotes and macrophage-engulfed amastigotes, whereas the in vivo experiments included comparative treatments of skin lesions in L. major -infected mice with Eucerin-formulated ES and Glucantime. Results The half maximal inhibitory concentrations of the crude ES, > 10-kDa ES fraction, < 10-kDa ES fraction, and Glucantime were 38.7 μg/ml, 47.6 μg/ml, 63.3 μg/ml, and 29.1 μg/ml, respectively. Significant differences were observed between percentage viabilities of promastigotes treated with the crude ES and its fractions compared with the negative control ( P < 0.0001). The crude ES was more effective on amastigotes than the two ES fractions at 300 μg/ml. The macroscopic measurements revealed that the reduction of lesion size in mice treated with the crude ES followed quicker cascades of healing than that of mice treated with Glucantime and the ES fractions. Conclusions The present study showed that the larval ES of L. sericata in both crude and fractionated forms are effective for both intracellular and extracellular forms of L. major . Also, the ES exert both topical and systemic effects on mice experimentally infected with L. major . Graphical abstract" @default.
• W4283018236 created "2022-06-18" @default.
• W4283018236 creator A5006720918 @default.
• W4283018236 creator A5008260461 @default.
• W4283018236 creator A5072722272 @default.
• W4283018236 date "2022-06-16" @default.
• W4283018236 modified "2023-10-14" @default.
• W4283018236 title "Therapeutic effects of Lucilia sericata larval excretion/secretion products on Leishmania major under in vitro and in vivo conditions" @default.
• W4283018236 cites W1564221315 @default.
• W4283018236 cites W1793577280 @default.
• W4283018236 cites W1918913058 @default.
• W4283018236 cites W1974046093 @default.
• W4283018236 cites W1981219820 @default.
• W4283018236 cites W2002493949 @default.
• W4283018236 cites W2026491092 @default.
• W4283018236 cites W2031089510 @default.
• W4283018236 cites W2031722061 @default.
• W4283018236 cites W2034293214 @default.
• W4283018236 cites W2034962303 @default.
• W4283018236 cites W2047581463 @default.
• W4283018236 cites W2049423468 @default.
• W4283018236 cites W2052841437 @default.
• W4283018236 cites W2056470069 @default.
• W4283018236 cites W2058136774 @default.
• W4283018236 cites W2068541511 @default.
• W4283018236 cites W2072945056 @default.
• W4283018236 cites W2074505948 @default.
• W4283018236 cites W2077052958 @default.
• W4283018236 cites W2079051443 @default.
• W4283018236 cites W2083623816 @default.
• W4283018236 cites W2089466401 @default.
• W4283018236 cites W2092403245 @default.
• W4283018236 cites W2092756371 @default.
• W4283018236 cites W2111398296 @default.
• W4283018236 cites W2116171405 @default.
• W4283018236 cites W2116833565 @default.
• W4283018236 cites W2130358862 @default.
• W4283018236 cites W2285866637 @default.
• W4283018236 cites W2296520086 @default.
• W4283018236 cites W2324612039 @default.
• W4283018236 cites W2467553170 @default.
• W4283018236 cites W2474438128 @default.
• W4283018236 cites W2507521849 @default.
• W4283018236 cites W2523775984 @default.
• W4283018236 cites W2607043161 @default.
• W4283018236 cites W2612178877 @default.
• W4283018236 cites W2615265512 @default.
• W4283018236 cites W2753707531 @default.
• W4283018236 cites W2763169689 @default.
• W4283018236 cites W2791033941 @default.
• W4283018236 cites W2918122250 @default.
• W4283018236 cites W2971783166 @default.
• W4283018236 cites W3003192558 @default.
• W4283018236 cites W3007951768 @default.
• W4283018236 cites W3017942183 @default.
• W4283018236 cites W3112039364 @default.
• W4283018236 cites W3136931345 @default.
• W4283018236 cites W3169119791 @default.
• W4283018236 cites W4248105672 @default.
• W4283018236 doi "https://doi.org/10.1186/s13071-022-05322-7" @default.
• W4283018236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35710519" @default.
• W4283018236 hasPublicationYear "2022" @default.
• W4283018236 type Work @default.
• W4283018236 citedByCount "3" @default.
• W4283018236 countsByYear W42830182362023 @default.
• W4283018236 crossrefType "journal-article" @default.
• W4283018236 hasAuthorship W4283018236A5006720918 @default.
• W4283018236 hasAuthorship W4283018236A5008260461 @default.
• W4283018236 hasAuthorship W4283018236A5072722272 @default.
• W4283018236 hasBestOaLocation W42830182361 @default.
• W4283018236 hasConcept C10146269 @default.
• W4283018236 hasConcept C136764020 @default.
• W4283018236 hasConcept C150903083 @default.
• W4283018236 hasConcept C173758957 @default.
• W4283018236 hasConcept C202751555 @default.
• W4283018236 hasConcept C203014093 @default.
• W4283018236 hasConcept C207001950 @default.
• W4283018236 hasConcept C2776555147 @default.
• W4283018236 hasConcept C2778207175 @default.
• W4283018236 hasConcept C2778575784 @default.
• W4283018236 hasConcept C2778702967 @default.
• W4283018236 hasConcept C2780599195 @default.
• W4283018236 hasConcept C2781092759 @default.
• W4283018236 hasConcept C41008148 @default.
• W4283018236 hasConcept C55493867 @default.
• W4283018236 hasConcept C59822182 @default.
• W4283018236 hasConcept C71928629 @default.
• W4283018236 hasConcept C86803240 @default.
• W4283018236 hasConcept C89423630 @default.
• W4283018236 hasConcept C98274493 @default.
• W4283018236 hasConcept C98319499 @default.
• W4283018236 hasConceptScore W4283018236C10146269 @default.
• W4283018236 hasConceptScore W4283018236C136764020 @default.
• W4283018236 hasConceptScore W4283018236C150903083 @default.
• W4283018236 hasConceptScore W4283018236C173758957 @default.
• W4283018236 hasConceptScore W4283018236C202751555 @default.
• W4283018236 hasConceptScore W4283018236C203014093 @default.
• W4283018236 hasConceptScore W4283018236C207001950 @default.
• W4283018236 hasConceptScore W4283018236C2776555147 @default.
• W4283018236 hasConceptScore W4283018236C2778207175 @default.

• next