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- W4283020110 abstract "Abstract Background Children with Mycoplasma pneumoniae pneumonia (MPP) exhibit decreased CD47 expression, which correlates with disease. CD47 expression is suppressed by miR-222-3p, which is elevated in MPP, and CD47 interaction with receptor SIRPα promotes phagocytosis. We hypothesized that suppressed CD47 expression contributes to the development of MPP. Methods Ninety-three children hospitalized at Children’s Hospital of Soochow University and requiring bronchoscopy were enrolled in the study; 65 were diagnosed with MPP (MPP group) and 28 presented with a bronchial foreign body (control group). Blood tests/biochemistry and cellular/humoral immunity markers were evaluated. miR-222-3p, CD47 and SIRPα expressions in bronchoalveolar lavage fluid (BALF) were determined using RT-qPCR and IL-4, IL-6, and IL-8 using ELISA. Results The MPP group displayed disordered coagulation, increased CD19 + CD23+, and ratio of CD4+/CD8 + cells, and increased IgA, IgG, and IgM concentrations (P < 0.05). The BALF cellular content in the MPP group revealed a decrease in macrophages and an increase in neutrophils (P < 0.05). miR-222-3p, IL-4, IL-6, and IL-8 expression in BALF was greater in the MPP group (P < 0.05) while CD47 and SIRPα expression was suppressed (P < 0.05). CD47 expression positively correlated with SIRPα and negatively correlated with miR-222-3P, IL-4, IL-6, IL-8 (P < 0.05). Conclusions Low CD47 and SIRPα expression in children with MPP likely leads macrophages to engulf Mycoplasma pneumoniae and mediate an inflammatory response. IL-4, IL-6, and IL-8 are associated with development of MPP and could be useful as a reference index to judge the degree of inflammation." @default.
- W4283020110 created "2022-06-18" @default.
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- W4283020110 date "2022-06-16" @default.
- W4283020110 modified "2023-10-16" @default.
- W4283020110 title "Potential mechanism of CD47 in Mycoplasma pneumoniae pneumonia" @default.
- W4283020110 doi "https://doi.org/10.21203/rs.3.rs-1715071/v1" @default.
- W4283020110 hasPublicationYear "2022" @default.
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