Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283020937> ?p ?o ?g. }
- W4283020937 endingPage "1290" @default.
- W4283020937 startingPage "1290" @default.
- W4283020937 abstract "The dried stigmas of Crocus sativus L. (Iridaceae) are traditionally processed to produce saffron, a spice widely used as a food coloring and flavoring agent, which is important in the pharmaceutical and textile dye-producing industries. The labor-intensive by-hand harvesting and the use of only a small amount of each flower cause saffron to be the most expensive spice in the world. Crocus sp. petals are by-products of saffron production and represent an interesting raw material for the preparation of extracts intended for health protection in the perspective of a circular economy. In the present study, ethanolic extract from Crocus sativus L. petals (Crocus sativus L. petal extract, CsPE) was tested on macrophages by in vitro models of inflammation and osteoclastogenesis. The extract was found to be endowed with anti-inflammatory activity, significantly reducing the nitric oxide production and IL-6 release by RAW 264.7 murine cells. Moreover, CsPE demonstrated an anti-osteoclastogenic effect, as revealed by a complete inhibition of tartrate-resistant acid phosphatase (TRAP)-positive osteoclast formation and a decreased expression of key osteoclast-related genes. This study, which focuses on the macrophage as the target cell of the bioactive extract from Crocus sativus L. petals, suggests that the petal by-product of saffron processing can usefully be part of a circular economy network aimed at producing an extract that potentially prevents bone disruption." @default.
- W4283020937 created "2022-06-18" @default.
- W4283020937 creator A5021481850 @default.
- W4283020937 creator A5028097286 @default.
- W4283020937 creator A5047813375 @default.
- W4283020937 creator A5061339768 @default.
- W4283020937 creator A5061844227 @default.
- W4283020937 creator A5065656217 @default.
- W4283020937 creator A5077471218 @default.
- W4283020937 creator A5087829389 @default.
- W4283020937 date "2022-06-17" @default.
- W4283020937 modified "2023-09-30" @default.
- W4283020937 title "Crocus sativus L. Petal Extract Inhibits Inflammation and Osteoclastogenesis in RAW 264.7 Cell Model" @default.
- W4283020937 cites W1535110134 @default.
- W4283020937 cites W1862241321 @default.
- W4283020937 cites W1976176778 @default.
- W4283020937 cites W2014620242 @default.
- W4283020937 cites W2021016137 @default.
- W4283020937 cites W2027215054 @default.
- W4283020937 cites W2027508606 @default.
- W4283020937 cites W2031466740 @default.
- W4283020937 cites W2032922770 @default.
- W4283020937 cites W2039615256 @default.
- W4283020937 cites W2040337853 @default.
- W4283020937 cites W2042123130 @default.
- W4283020937 cites W2068176262 @default.
- W4283020937 cites W2084319580 @default.
- W4283020937 cites W2101459489 @default.
- W4283020937 cites W2115219445 @default.
- W4283020937 cites W2158070898 @default.
- W4283020937 cites W2188591325 @default.
- W4283020937 cites W2244844822 @default.
- W4283020937 cites W231343894 @default.
- W4283020937 cites W2478096332 @default.
- W4283020937 cites W2491700311 @default.
- W4283020937 cites W2606722962 @default.
- W4283020937 cites W2621823771 @default.
- W4283020937 cites W2760730058 @default.
- W4283020937 cites W2794814583 @default.
- W4283020937 cites W2799784143 @default.
- W4283020937 cites W2800808913 @default.
- W4283020937 cites W2803973097 @default.
- W4283020937 cites W2883400524 @default.
- W4283020937 cites W2891046942 @default.
- W4283020937 cites W2898404024 @default.
- W4283020937 cites W2964552970 @default.
- W4283020937 cites W2967267233 @default.
- W4283020937 cites W2978430409 @default.
- W4283020937 cites W2981939716 @default.
- W4283020937 cites W3003939541 @default.
- W4283020937 cites W3013522609 @default.
- W4283020937 cites W3014146563 @default.
- W4283020937 cites W3037089604 @default.
- W4283020937 cites W3040751232 @default.
- W4283020937 cites W3045803663 @default.
- W4283020937 cites W3083952170 @default.
- W4283020937 cites W3085653110 @default.
- W4283020937 cites W3093208992 @default.
- W4283020937 cites W3093365748 @default.
- W4283020937 cites W3100184869 @default.
- W4283020937 cites W3107854795 @default.
- W4283020937 cites W3123345304 @default.
- W4283020937 cites W3135046771 @default.
- W4283020937 cites W3143279666 @default.
- W4283020937 cites W3170009450 @default.
- W4283020937 cites W3174314935 @default.
- W4283020937 cites W3183441742 @default.
- W4283020937 cites W3186345730 @default.
- W4283020937 cites W3198390820 @default.
- W4283020937 cites W3204508218 @default.
- W4283020937 cites W3210219832 @default.
- W4283020937 cites W4205393898 @default.
- W4283020937 cites W4210324600 @default.
- W4283020937 doi "https://doi.org/10.3390/pharmaceutics14061290" @default.
- W4283020937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35745865" @default.
- W4283020937 hasPublicationYear "2022" @default.
- W4283020937 type Work @default.
- W4283020937 citedByCount "3" @default.
- W4283020937 countsByYear W42830209372022 @default.
- W4283020937 countsByYear W42830209372023 @default.
- W4283020937 crossrefType "journal-article" @default.
- W4283020937 hasAuthorship W4283020937A5021481850 @default.
- W4283020937 hasAuthorship W4283020937A5028097286 @default.
- W4283020937 hasAuthorship W4283020937A5047813375 @default.
- W4283020937 hasAuthorship W4283020937A5061339768 @default.
- W4283020937 hasAuthorship W4283020937A5061844227 @default.
- W4283020937 hasAuthorship W4283020937A5065656217 @default.
- W4283020937 hasAuthorship W4283020937A5077471218 @default.
- W4283020937 hasAuthorship W4283020937A5087829389 @default.
- W4283020937 hasBestOaLocation W42830209371 @default.
- W4283020937 hasConcept C120545014 @default.
- W4283020937 hasConcept C185592680 @default.
- W4283020937 hasConcept C2776337548 @default.
- W4283020937 hasConcept C2777637054 @default.
- W4283020937 hasConcept C2779571273 @default.
- W4283020937 hasConcept C2780715101 @default.
- W4283020937 hasConcept C31903555 @default.
- W4283020937 hasConcept C55493867 @default.