FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283028311> ?p ?o ?g. }

• W4283028311 abstract "Although dairy intake has been shown to have a neutral or some beneficial effect on major cardiometabolic risk factors, the impact of dairy, and especially dairy fat, on immune function remains to be investigated. To understand the effect of consuming dairy fat on cardiometabolic risk factors and immune function, we used an established low birthweight (LBW) swine model of diet-induced insulin resistance to compare high-fat and low-fat dairy products to a control high-fat diet (CHF). LBW piglets were randomized to consume one of the 3 experimental HF diets: (1) CHF, (2) CHF diet supplemented with 3 servings/day of high-fat dairy (HFDairy) and (3) CHF diet supplemented with 3 servings/day of low-fat dairy (LFDairy). As comparison groups, normal birthweight (NBW) piglets were fed a CHF (NBW-CHF) or standard pig grower diet (NBW-Chow). A total of 35 pigs completed the study and were fed for a total of 7 weeks, including 1 week of CHF transition diet. At 12 weeks of age, piglets were euthanized. Fasting blood and tissue samples were collected. Ex vivo cytokine production by peripheral blood mononuclear cells (PBMCs) stimulated with pokeweed (PWM), phytohemagglutinin (PHA) and phorbol myristate acetate-ionomycin (PMA-I) were assessed. As expected, LBW-CHF piglets showed early signs of insulin resistance (HOMA-IR, P model = 0.08). Feeding high-fat dairy products improved fasting plasma glucose concentrations more than low-fat dairy compared to LBW-CHF ( P &lt; 0.05). Irrespective of fat content, dairy consumption had neutral effect on fasting lipid profile. We have also observed lower production of IL-2 after PWM and PHA stimulation as well as lower production of TNF-α and IFN-γ after PWM stimulation in LBW-CHF than in NBW-Chow (all, P &lt; 0.05), suggesting impaired T cell and antigen presenting cell function. While feeding high-fat dairy had minimal effect on immune function, feeding low-fat dairy significantly improved the production of IL-2, TNF-α and IFN-γ after PWM stimulation, IL-2 and IFN-γ after PHA stimulation as well as TNF-α after PMA-I stimulation compared to LBW-CHF (all, P &lt; 0.05). These data provide novel insights into the role of dairy consumption in counteracting some obesity-related cardiometabolic and immune perturbations." @default.
• W4283028311 created "2022-06-18" @default.
• W4283028311 creator A5004078949 @default.
• W4283028311 creator A5029808251 @default.
• W4283028311 creator A5030691366 @default.
• W4283028311 creator A5034805295 @default.
• W4283028311 creator A5047028631 @default.
• W4283028311 creator A5059872775 @default.
• W4283028311 creator A5069891436 @default.
• W4283028311 creator A5078668623 @default.
• W4283028311 date "2022-06-17" @default.
• W4283028311 modified "2023-10-18" @default.
• W4283028311 title "Effect of High-Fat and Low-Fat Dairy Products on Cardiometabolic Risk Factors and Immune Function in a Low Birthweight Swine Model of Diet-Induced Insulin Resistance" @default.
• W4283028311 cites W1541608094 @default.
• W4283028311 cites W1799339811 @default.
• W4283028311 cites W1961576110 @default.
• W4283028311 cites W1979245738 @default.
• W4283028311 cites W2022091218 @default.
• W4283028311 cites W2022142180 @default.
• W4283028311 cites W2041492180 @default.
• W4283028311 cites W2076973333 @default.
• W4283028311 cites W2093537833 @default.
• W4283028311 cites W2106684817 @default.
• W4283028311 cites W2128382817 @default.
• W4283028311 cites W2135909428 @default.
• W4283028311 cites W2149357130 @default.
• W4283028311 cites W2164023673 @default.
• W4283028311 cites W2294976580 @default.
• W4283028311 cites W2403366498 @default.
• W4283028311 cites W2409158180 @default.
• W4283028311 cites W2515488592 @default.
• W4283028311 cites W2549595479 @default.
• W4283028311 cites W2553359562 @default.
• W4283028311 cites W2555125137 @default.
• W4283028311 cites W2567214101 @default.
• W4283028311 cites W2594648396 @default.
• W4283028311 cites W2605431828 @default.
• W4283028311 cites W2612189159 @default.
• W4283028311 cites W2771968994 @default.
• W4283028311 cites W2801032953 @default.
• W4283028311 cites W2889517260 @default.
• W4283028311 cites W2896906720 @default.
• W4283028311 cites W2897756848 @default.
• W4283028311 cites W2901147774 @default.
• W4283028311 cites W2901557220 @default.
• W4283028311 cites W2915971168 @default.
• W4283028311 cites W2921553057 @default.
• W4283028311 cites W2943192903 @default.
• W4283028311 cites W2948019194 @default.
• W4283028311 cites W2979096256 @default.
• W4283028311 cites W2998756426 @default.
• W4283028311 cites W3003265560 @default.
• W4283028311 cites W3016020611 @default.
• W4283028311 cites W3024155893 @default.
• W4283028311 cites W3028398368 @default.
• W4283028311 cites W3120181244 @default.
• W4283028311 cites W3120977825 @default.
• W4283028311 cites W3127026580 @default.
• W4283028311 cites W3135171367 @default.
• W4283028311 cites W3137274905 @default.
• W4283028311 cites W3152705473 @default.
• W4283028311 cites W3182663601 @default.
• W4283028311 cites W3206502406 @default.
• W4283028311 cites W4200022914 @default.
• W4283028311 cites W4210474003 @default.
• W4283028311 doi "https://doi.org/10.3389/fnut.2022.923120" @default.
• W4283028311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35782930" @default.
• W4283028311 hasPublicationYear "2022" @default.
• W4283028311 type Work @default.
• W4283028311 citedByCount "3" @default.
• W4283028311 countsByYear W42830283112022 @default.
• W4283028311 countsByYear W42830283112023 @default.
• W4283028311 crossrefType "journal-article" @default.
• W4283028311 hasAuthorship W4283028311A5004078949 @default.
• W4283028311 hasAuthorship W4283028311A5029808251 @default.
• W4283028311 hasAuthorship W4283028311A5030691366 @default.
• W4283028311 hasAuthorship W4283028311A5034805295 @default.
• W4283028311 hasAuthorship W4283028311A5047028631 @default.
• W4283028311 hasAuthorship W4283028311A5059872775 @default.
• W4283028311 hasAuthorship W4283028311A5069891436 @default.
• W4283028311 hasAuthorship W4283028311A5078668623 @default.
• W4283028311 hasBestOaLocation W42830283111 @default.
• W4283028311 hasConcept C126322002 @default.
• W4283028311 hasConcept C134018914 @default.
• W4283028311 hasConcept C140793950 @default.
• W4283028311 hasConcept C203014093 @default.
• W4283028311 hasConcept C2776977481 @default.
• W4283028311 hasConcept C2777391703 @default.
• W4283028311 hasConcept C2779306644 @default.
• W4283028311 hasConcept C71924100 @default.
• W4283028311 hasConcept C86803240 @default.
• W4283028311 hasConcept C8891405 @default.
• W4283028311 hasConceptScore W4283028311C126322002 @default.
• W4283028311 hasConceptScore W4283028311C134018914 @default.
• W4283028311 hasConceptScore W4283028311C140793950 @default.
• W4283028311 hasConceptScore W4283028311C203014093 @default.
• W4283028311 hasConceptScore W4283028311C2776977481 @default.
• W4283028311 hasConceptScore W4283028311C2777391703 @default.
• W4283028311 hasConceptScore W4283028311C2779306644 @default.
• W4283028311 hasConceptScore W4283028311C71924100 @default.

• next