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- W4283029194 abstract "Abstract Memory-phenotype (MP) CD4 + T cells are a substantial population of conventional T cells that exist in steady-state mice, and their immunologic functions in autoimmune disease have not yet been studied. In this work, we unveil a unique phenotype of MP CD4 + T cells by analyzing single-cell transcriptomics and T cell receptor (TCR) repertoires. We found that steady-state MP CD4 + T cells exist regardless of germ and food-antigen which are composed of heterogenous effector subpopulations. Distinct subpopulations of MP CD4 + T cells are specifically activated by IL-1 family cytokines and STAT activators, revealing that the cells have TCR-independent effector functions. Especially, CCR6 high MP CD4 + T cells are major responders to IL-1β and IL-23 without MOG 35-55 antigen reactivity, which gives them pathogenic-Th17 characteristics and allows them to contribute to autoimmune encephalomyelitis. We identified Bhlhe40 in CCR6 high MP CD4 + T cells drives the expression of GM-CSF, contributing to CNS pathology in experimental autoimmune encephalomyelitis. Collectively, our findings reveal heterogeneity of MP CD4 + T cells that can contribute to autoimmune neuroinflammation in bystander manner synergistically with antigen-specific T cells." @default.
- W4283029194 created "2022-06-18" @default.
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- W4283029194 date "2022-06-17" @default.
- W4283029194 modified "2023-10-17" @default.
- W4283029194 title "Bystander memory-phenotype conventional CD4<sup>+</sup>T cells exacerbating autoimmune neuroinflammation" @default.
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- W4283029194 doi "https://doi.org/10.1101/2022.06.17.496529" @default.
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