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• W4283065714 abstract "Obesity is one of the most common diseases of civilization, and approximately 13 % of the world's adult population is obese. Obesity is defined as excessive accumulation of fat in the human body, which leads to adverse health effects such as metabolic syndrome, type 2 diabetes, and fatty liver disease (e.g., nonalcoholic liver disease). The development of obesity is accompanied by changes in the levels of certain bioelements such as copper and zinc. These elements may have an influence on the proper functioning of the central nervous system.Fifty-six male Wistar rats (initial weight 290-300 g) were divided into seven experimental groups. They were fed with different feeding patterns (constant versus intermittent-binge access) and exposed to different diets (high sucrose versus high fat) to analyze the factors that affect the organ weight gain (pancreas, spleen, liver, testes, and kidneys) and total body weight gain. Further, zinc and copper levels in the serum of the animals were determined. The relationship between organ and body weight and serum metal concentration was analyzed by cluster and principal component analyses.Rats with unlimited access to high fat diet (HF) and restricted intake of high sugar diet (for 2-hours daily-HSB and every second day-IHSB) have elevated body weight in comparison to the control. However, the heaviest organ weights were recorded in the HSB rats compared to the control group (pancreas, 14 %; spleen, 9 %; kidneys, 5 %; and liver, 3 %). On the other hand, an average 20 % decrease in zinc concentration was observed in rats fed with high-fat diet compared to the control. Moreover, an 18 % decrease in copper levels was observed in rats that had periodic access to high-fat diet every 2 h daily and for 2 h every other day compared to the control.Both the high-sucrose and high-fat diets had an influence on body and organ weights. This study demonstrates an association between the different types of diet and the parameters investigated (body and organ weights and concentration of serum bioelements)." @default.
• W4283065714 created "2022-06-19" @default.
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• W4283065714 date "2022-09-01" @default.
• W4283065714 modified "2023-10-01" @default.
• W4283065714 title "The influence of high-fat and high-sucrose feeding regimes on organ weight, body weight, and serum concentration of bioelements in rats" @default.
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• W4283065714 doi "https://doi.org/10.1016/j.jtemb.2022.127020" @default.
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