FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283066935> ?p ?o ?g. }

• W4283066935 endingPage "28475" @default.
• W4283066935 startingPage "28455" @default.
• W4283066935 abstract "Critical bone defects with a sluggish rate of auto-osteoconduction and imperfect reconstruction are motivators for the development of an alternate innovative approach for the regeneration of bone. Tissue engineering for bone regeneration signifies an advanced way to overcome this problem by creating an additional bone tissue substitute. Among different fabrication techniques, the 3D printing technique is obviously the most efficient and advanced way to fabricate an osteoconductive scaffold with a controlled porous structure. In the current article, the polycarbonate and polyester diol based polyurethane-urea (P12) was synthesized and 3D porous nanohybrid scaffolds (P12/TP-nHA) were fabricated using the 3D printing technique by incorporating the osteoconductive nanomaterial titanium phosphate adorned nanohydroxyapatite (TP-nHA). To improve the bioactivity, the surface of the fabricated scaffolds was modified with the immobilized biomolecule polydopamine (PDA) at room temperature. XPS study as well as the measurement of surface wettability confirmed the higher amount of PDA immobilization on TP-nHA incorporated nanohybrid scaffolds through the dative bone formation between the vacant d orbital of the incorporated titanium ion and the lone pair electron of the catechol group of dopamine. The incorporated titanium phosphate (TP) increased the tensile strength (53.1%) and elongation at break (96.8%) of the nanohybrid composite as compared to pristine P12. Moreover, the TP incorporated nanohybrid scaffold with calcium and phosphate moieties and a higher amount of immobilized active biomolecule improved the in vitro bioactivity, including the cell viability, cell proliferation, and osteogenic gene expression using hMSCs, of the fabricated nanohybrid scaffolds. A rat tibia defect model depicted that the TP incorporated nanohybrid scaffold with immobilized PDA enhanced the in vivo bone regeneration ability compared to the control sample without revealing any organ toxicity signifying the superior osteogenic bioactivity. Thus, a TP augmented polydopamine immobilized polyurethane-urea based nanohybrid 3D printed scaffold with improved physicochemical properties and osteogenic bioactivity could be utilized as an excellent advanced material for bone regeneration substitute." @default.
• W4283066935 created "2022-06-19" @default.
• W4283066935 creator A5032182253 @default.
• W4283066935 creator A5039944092 @default.
• W4283066935 creator A5047148317 @default.
• W4283066935 creator A5072756017 @default.
• W4283066935 creator A5077947010 @default.
• W4283066935 creator A5078690737 @default.
• W4283066935 creator A5081759943 @default.
• W4283066935 creator A5086126785 @default.
• W4283066935 date "2022-06-17" @default.
• W4283066935 modified "2023-10-17" @default.
• W4283066935 title "Metal Ion Augmented Mussel Inspired Polydopamine Immobilized 3D Printed Osteoconductive Scaffolds for Accelerated Bone Tissue Regeneration" @default.
• W4283066935 cites W1572706276 @default.
• W4283066935 cites W1770785006 @default.
• W4283066935 cites W1972451730 @default.
• W4283066935 cites W1974790802 @default.
• W4283066935 cites W1976500358 @default.
• W4283066935 cites W1977214686 @default.
• W4283066935 cites W1986500139 @default.
• W4283066935 cites W1987500206 @default.
• W4283066935 cites W1999071133 @default.
• W4283066935 cites W2016378412 @default.
• W4283066935 cites W2017224869 @default.
• W4283066935 cites W2021790237 @default.
• W4283066935 cites W2026286211 @default.
• W4283066935 cites W2036262690 @default.
• W4283066935 cites W2045383620 @default.
• W4283066935 cites W2060216842 @default.
• W4283066935 cites W2061310848 @default.
• W4283066935 cites W2072447060 @default.
• W4283066935 cites W2091853021 @default.
• W4283066935 cites W2100931541 @default.
• W4283066935 cites W2126438640 @default.
• W4283066935 cites W2132131875 @default.
• W4283066935 cites W2194100348 @default.
• W4283066935 cites W2235627208 @default.
• W4283066935 cites W2267854315 @default.
• W4283066935 cites W2319860567 @default.
• W4283066935 cites W2323258862 @default.
• W4283066935 cites W2404121463 @default.
• W4283066935 cites W2578851460 @default.
• W4283066935 cites W2605908661 @default.
• W4283066935 cites W2623981860 @default.
• W4283066935 cites W2746778334 @default.
• W4283066935 cites W2754538438 @default.
• W4283066935 cites W2791792013 @default.
• W4283066935 cites W2802912347 @default.
• W4283066935 cites W2888331203 @default.
• W4283066935 cites W2894065078 @default.
• W4283066935 cites W2901631637 @default.
• W4283066935 cites W2903066046 @default.
• W4283066935 cites W2908079042 @default.
• W4283066935 cites W2911972687 @default.
• W4283066935 cites W2912880623 @default.
• W4283066935 cites W2925331595 @default.
• W4283066935 cites W2941843716 @default.
• W4283066935 cites W2960491998 @default.
• W4283066935 cites W2961085314 @default.
• W4283066935 cites W2969301237 @default.
• W4283066935 cites W2989734340 @default.
• W4283066935 cites W3081158075 @default.
• W4283066935 cites W3089221467 @default.
• W4283066935 cites W3126630152 @default.
• W4283066935 cites W3181661995 @default.
• W4283066935 cites W3198197177 @default.
• W4283066935 cites W4229794550 @default.
• W4283066935 cites W903904613 @default.
• W4283066935 doi "https://doi.org/10.1021/acsami.2c01657" @default.
• W4283066935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35715225" @default.
• W4283066935 hasPublicationYear "2022" @default.
• W4283066935 type Work @default.
• W4283066935 citedByCount "7" @default.
• W4283066935 countsByYear W42830669352022 @default.
• W4283066935 countsByYear W42830669352023 @default.
• W4283066935 crossrefType "journal-article" @default.
• W4283066935 hasAuthorship W4283066935A5032182253 @default.
• W4283066935 hasAuthorship W4283066935A5039944092 @default.
• W4283066935 hasAuthorship W4283066935A5047148317 @default.
• W4283066935 hasAuthorship W4283066935A5072756017 @default.
• W4283066935 hasAuthorship W4283066935A5077947010 @default.
• W4283066935 hasAuthorship W4283066935A5078690737 @default.
• W4283066935 hasAuthorship W4283066935A5081759943 @default.
• W4283066935 hasAuthorship W4283066935A5086126785 @default.
• W4283066935 hasConcept C115537861 @default.
• W4283066935 hasConcept C127413603 @default.
• W4283066935 hasConcept C136229726 @default.
• W4283066935 hasConcept C159985019 @default.
• W4283066935 hasConcept C171056886 @default.
• W4283066935 hasConcept C171250308 @default.
• W4283066935 hasConcept C192562407 @default.
• W4283066935 hasConcept C2778606738 @default.
• W4283066935 hasConcept C2779868350 @default.
• W4283066935 hasConcept C42360764 @default.
• W4283066935 hasConcept C49853544 @default.
• W4283066935 hasConcept C49892992 @default.
• W4283066935 hasConcept C521977710 @default.
• W4283066935 hasConcept C71924100 @default.

• next