FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283070333> ?p ?o ?g. }

• W4283070333 endingPage "753" @default.
• W4283070333 startingPage "747" @default.
• W4283070333 abstract "This study investigated the impact of magnetic mesoporous silica nanoparticles (MMSN)-encapsulated X-linked inhibitor of apoptosis protein (XIAP) and miR-233 on tumor microenvironment in cervical cancer, to provide targeted treatment and strategy, to improve radio sensitization of cancer cells. Cervical cancer cells were treated with normal saline (control group), XIAP-loaded metallic mesoporous silica nanoparticles (MMSNs), and miR-233-targeted material (XIAP group, XIAP+miR-233 group). Proliferation, apoptosis and colony forming ability of cancer cells were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method, flow cytometry and colony formation experiments. In vivo experiments were established to observe the impact of XIAP-loaded MMSNs and miR-233 on tumor growth. Administration of XIAP-loaded MMSNs suppressed tumor growth of cervical cancer, and presence of miR-233 targeted material further decreased tumor volume, increasing radio sensitization of cancer cells. In vitro experiments confirmed that, combined treatment of XIAP and miR-233 suppressed cancer cell proliferation and invasion when inducing apoptosis. XIAP MMSNs characterized by large unit surface area, high dispersion and adhesion, and prolonged circulation time, improving drug delivery and treatment selectivity of chemotherapeutic drugs. This study suggests that XIAP MMSNs with miR-233 material suppress cervical cancer cell progression and tumor growth when augmenting radiosensitization of cancer cells, providing evidence for targeted therapy for the disease." @default.
• W4283070333 created "2022-06-19" @default.
• W4283070333 creator A5001969147 @default.
• W4283070333 creator A5005815377 @default.
• W4283070333 creator A5012152127 @default.
• W4283070333 creator A5022802322 @default.
• W4283070333 creator A5047916176 @default.
• W4283070333 creator A5066730504 @default.
• W4283070333 creator A5085377271 @default.
• W4283070333 date "2022-03-01" @default.
• W4283070333 modified "2023-09-29" @default.
• W4283070333 title "X-Linked Inhibitor of Apoptosis Protein (XIAP)-Loaded Magnetic Mesoporous Silica Nanoparticles Incorporated with miR-233 to Improve Radio Sensitization of Cervical Cancer Cells and Promote Apoptosis" @default.
• W4283070333 cites W1488302720 @default.
• W4283070333 cites W149822561 @default.
• W4283070333 cites W1860742310 @default.
• W4283070333 cites W1981774836 @default.
• W4283070333 cites W1999660608 @default.
• W4283070333 cites W2010642206 @default.
• W4283070333 cites W2012899584 @default.
• W4283070333 cites W2028486025 @default.
• W4283070333 cites W2037145474 @default.
• W4283070333 cites W2065436007 @default.
• W4283070333 cites W2066064555 @default.
• W4283070333 cites W2070003597 @default.
• W4283070333 cites W2072077758 @default.
• W4283070333 cites W2080852098 @default.
• W4283070333 cites W2091126906 @default.
• W4283070333 cites W2215362841 @default.
• W4283070333 cites W2314180467 @default.
• W4283070333 cites W2346133077 @default.
• W4283070333 cites W2415237877 @default.
• W4283070333 cites W2464231245 @default.
• W4283070333 cites W2626318019 @default.
• W4283070333 cites W2777363333 @default.
• W4283070333 cites W2793919896 @default.
• W4283070333 cites W2799592570 @default.
• W4283070333 cites W2899135644 @default.
• W4283070333 cites W2905246928 @default.
• W4283070333 cites W2907991785 @default.
• W4283070333 cites W2909031803 @default.
• W4283070333 cites W3005708950 @default.
• W4283070333 cites W3039210207 @default.
• W4283070333 cites W3088986733 @default.
• W4283070333 cites W3101888604 @default.
• W4283070333 cites W3169439592 @default.
• W4283070333 cites W3176833090 @default.
• W4283070333 doi "https://doi.org/10.1166/jbn.2022.3281" @default.
• W4283070333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35715921" @default.
• W4283070333 hasPublicationYear "2022" @default.
• W4283070333 type Work @default.
• W4283070333 citedByCount "0" @default.
• W4283070333 crossrefType "journal-article" @default.
• W4283070333 hasAuthorship W4283070333A5001969147 @default.
• W4283070333 hasAuthorship W4283070333A5005815377 @default.
• W4283070333 hasAuthorship W4283070333A5012152127 @default.
• W4283070333 hasAuthorship W4283070333A5022802322 @default.
• W4283070333 hasAuthorship W4283070333A5047916176 @default.
• W4283070333 hasAuthorship W4283070333A5066730504 @default.
• W4283070333 hasAuthorship W4283070333A5085377271 @default.
• W4283070333 hasConcept C121608353 @default.
• W4283070333 hasConcept C126322002 @default.
• W4283070333 hasConcept C161790260 @default.
• W4283070333 hasConcept C185592680 @default.
• W4283070333 hasConcept C190283241 @default.
• W4283070333 hasConcept C192562407 @default.
• W4283070333 hasConcept C2777408456 @default.
• W4283070333 hasConcept C2777496208 @default.
• W4283070333 hasConcept C2778220009 @default.
• W4283070333 hasConcept C31573885 @default.
• W4283070333 hasConcept C33195913 @default.
• W4283070333 hasConcept C502942594 @default.
• W4283070333 hasConcept C55493867 @default.
• W4283070333 hasConcept C71924100 @default.
• W4283070333 hasConcept C82776694 @default.
• W4283070333 hasConcept C96232424 @default.
• W4283070333 hasConcept C98424977 @default.
• W4283070333 hasConceptScore W4283070333C121608353 @default.
• W4283070333 hasConceptScore W4283070333C126322002 @default.
• W4283070333 hasConceptScore W4283070333C161790260 @default.
• W4283070333 hasConceptScore W4283070333C185592680 @default.
• W4283070333 hasConceptScore W4283070333C190283241 @default.
• W4283070333 hasConceptScore W4283070333C192562407 @default.
• W4283070333 hasConceptScore W4283070333C2777408456 @default.
• W4283070333 hasConceptScore W4283070333C2777496208 @default.
• W4283070333 hasConceptScore W4283070333C2778220009 @default.
• W4283070333 hasConceptScore W4283070333C31573885 @default.
• W4283070333 hasConceptScore W4283070333C33195913 @default.
• W4283070333 hasConceptScore W4283070333C502942594 @default.
• W4283070333 hasConceptScore W4283070333C55493867 @default.
• W4283070333 hasConceptScore W4283070333C71924100 @default.
• W4283070333 hasConceptScore W4283070333C82776694 @default.
• W4283070333 hasConceptScore W4283070333C96232424 @default.
• W4283070333 hasConceptScore W4283070333C98424977 @default.
• W4283070333 hasIssue "3" @default.
• W4283070333 hasLocation W42830703331 @default.
• W4283070333 hasLocation W42830703332 @default.
• W4283070333 hasOpenAccess W4283070333 @default.
• W4283070333 hasPrimaryLocation W42830703331 @default.

• next