Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283070830> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4283070830 endingPage "237" @default.
- W4283070830 startingPage "226" @default.
- W4283070830 abstract "Purpose: Renzhu ointment (Renzhuqigao, RZQG) is a patented herbal drug derived from Chinese traditional medicine formula and modern clinical experience for the transdermal treatment of non-infectious infantile diarrhoea. The safety of RZQG in preclinical studies has not been reported.Materials and methods: In this study, the pups of parent rats were examined for sub-chronic toxicity and developmental toxicity. After 21 days of birth, they were exposed to RZQG through their abdominal skin at doses of 0.1, 0.3, and 0.9 g/kg/day for 4 weeks and then were observed for another four weeks during their recovery period.Results: During the administration period, RZQG had no significant toxicological effect on body weight, food consumption, external eye examination, urinalysis, bone marrow examination, histopathology, central nervous system, reproductive system, or skeletal development. However, in the 0.9 g/kg/day group, the skin of some rats became dry and cracked, red and swollen, forming a white scab, while the white blood cells (WBC) count in female rats was lower and cholesterol (CHOL), triglycerides (TG), and glutamyl-transferase (GGT) were higher (p < 0.05).Conclusions: Rats receiving 0.9 g/kg/day exhibited skin irritation and were suspected to have a mild liver injury. There was no evidence of delayed toxicity four weeks after withdrawal. Therefore, the no-observed adverse effect level of RZQG was 0.3 g/kg/day (30 times the clinical dose planned and 4.92 times the human equivalent dose)." @default.
- W4283070830 created "2022-06-19" @default.
- W4283070830 creator A5018222802 @default.
- W4283070830 creator A5049428000 @default.
- W4283070830 creator A5050861802 @default.
- W4283070830 creator A5055659539 @default.
- W4283070830 creator A5069444065 @default.
- W4283070830 creator A5071672663 @default.
- W4283070830 creator A5076604571 @default.
- W4283070830 creator A5077115316 @default.
- W4283070830 creator A5086637531 @default.
- W4283070830 date "2022-06-24" @default.
- W4283070830 modified "2023-10-18" @default.
- W4283070830 title "Sub-chronic and developmental toxicity of transdermal delivery of Renzhu ointment in young SD rats" @default.
- W4283070830 cites W2016144148 @default.
- W4283070830 cites W2022499743 @default.
- W4283070830 cites W2024255851 @default.
- W4283070830 cites W2035603099 @default.
- W4283070830 cites W2039157028 @default.
- W4283070830 cites W2158601373 @default.
- W4283070830 cites W2159761322 @default.
- W4283070830 cites W2310834706 @default.
- W4283070830 cites W2548273539 @default.
- W4283070830 cites W2808957667 @default.
- W4283070830 cites W2904932344 @default.
- W4283070830 cites W2995967418 @default.
- W4283070830 cites W3036982713 @default.
- W4283070830 cites W3092849554 @default.
- W4283070830 cites W3094329929 @default.
- W4283070830 cites W3113667356 @default.
- W4283070830 doi "https://doi.org/10.1080/15569527.2022.2088781" @default.
- W4283070830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35712753" @default.
- W4283070830 hasPublicationYear "2022" @default.
- W4283070830 type Work @default.
- W4283070830 citedByCount "1" @default.
- W4283070830 countsByYear W42830708302023 @default.
- W4283070830 crossrefType "journal-article" @default.
- W4283070830 hasAuthorship W4283070830A5018222802 @default.
- W4283070830 hasAuthorship W4283070830A5049428000 @default.
- W4283070830 hasAuthorship W4283070830A5050861802 @default.
- W4283070830 hasAuthorship W4283070830A5055659539 @default.
- W4283070830 hasAuthorship W4283070830A5069444065 @default.
- W4283070830 hasAuthorship W4283070830A5071672663 @default.
- W4283070830 hasAuthorship W4283070830A5076604571 @default.
- W4283070830 hasAuthorship W4283070830A5077115316 @default.
- W4283070830 hasAuthorship W4283070830A5086637531 @default.
- W4283070830 hasConcept C126322002 @default.
- W4283070830 hasConcept C142724271 @default.
- W4283070830 hasConcept C197934379 @default.
- W4283070830 hasConcept C205679159 @default.
- W4283070830 hasConcept C2777495288 @default.
- W4283070830 hasConcept C2778488018 @default.
- W4283070830 hasConcept C2779225474 @default.
- W4283070830 hasConcept C2780026642 @default.
- W4283070830 hasConcept C29730261 @default.
- W4283070830 hasConcept C42407357 @default.
- W4283070830 hasConcept C53164099 @default.
- W4283070830 hasConcept C544855455 @default.
- W4283070830 hasConcept C71924100 @default.
- W4283070830 hasConcept C98274493 @default.
- W4283070830 hasConceptScore W4283070830C126322002 @default.
- W4283070830 hasConceptScore W4283070830C142724271 @default.
- W4283070830 hasConceptScore W4283070830C197934379 @default.
- W4283070830 hasConceptScore W4283070830C205679159 @default.
- W4283070830 hasConceptScore W4283070830C2777495288 @default.
- W4283070830 hasConceptScore W4283070830C2778488018 @default.
- W4283070830 hasConceptScore W4283070830C2779225474 @default.
- W4283070830 hasConceptScore W4283070830C2780026642 @default.
- W4283070830 hasConceptScore W4283070830C29730261 @default.
- W4283070830 hasConceptScore W4283070830C42407357 @default.
- W4283070830 hasConceptScore W4283070830C53164099 @default.
- W4283070830 hasConceptScore W4283070830C544855455 @default.
- W4283070830 hasConceptScore W4283070830C71924100 @default.
- W4283070830 hasConceptScore W4283070830C98274493 @default.
- W4283070830 hasFunder F4320321001 @default.
- W4283070830 hasFunder F4320335795 @default.
- W4283070830 hasIssue "3" @default.
- W4283070830 hasLocation W42830708301 @default.
- W4283070830 hasLocation W42830708302 @default.
- W4283070830 hasOpenAccess W4283070830 @default.
- W4283070830 hasPrimaryLocation W42830708301 @default.
- W4283070830 hasRelatedWork W1988133213 @default.
- W4283070830 hasRelatedWork W1994136014 @default.
- W4283070830 hasRelatedWork W2054169229 @default.
- W4283070830 hasRelatedWork W2099626796 @default.
- W4283070830 hasRelatedWork W2132960688 @default.
- W4283070830 hasRelatedWork W2258884813 @default.
- W4283070830 hasRelatedWork W2596429577 @default.
- W4283070830 hasRelatedWork W2945522913 @default.
- W4283070830 hasRelatedWork W3161051376 @default.
- W4283070830 hasRelatedWork W850202965 @default.
- W4283070830 hasVolume "41" @default.
- W4283070830 isParatext "false" @default.
- W4283070830 isRetracted "false" @default.
- W4283070830 workType "article" @default.