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- W4283072036 abstract "The tumor microenvironment (TME) plays an important role in neoplastic development. Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of the TME and degradation of the extracellular matrix (ECM) in a large variety of malignancies. Evidence has revealed that dysregulated MMPs can lead to ECM damage, the promotion of cell migration and tumor metastasis. The expression and activities of MMPs can be tightly regulated by TIMPs, multiple signaling pathways and noncoding RNAs. MMPs are also finely controlled by E3 ubiquitin ligases. The current review focuses on the molecular mechanism by which MMPs are governed by E3 ubiquitin ligases in carcinogenesis. Due to the essential role of MMPs in oncogenesis, they have been considered the attractive targets for antitumor treatment. Several strategies that target MMPs have been discovered, including the use of small-molecule inhibitors, peptides, inhibitory antibodies, natural compounds with anti-MMP activity, and RNAi therapeutics. However, these molecules have multiple disadvantages, such as poor solubility, severe side-effects and low oral bioavailability. Therefore, it is necessary to discover the novel inhibitors that suppress MMPs for cancer therapy. Here, we discuss the therapeutic potential of targeting E3 ubiquitin ligases to inhibit MMPs. We hope this review will stimulate the discovery of novel therapeutics for the MMP-targeted treatment of a variety of human cancers." @default.
- W4283072036 created "2022-06-19" @default.
- W4283072036 creator A5018113592 @default.
- W4283072036 creator A5038776482 @default.
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- W4283072036 creator A5077716269 @default.
- W4283072036 creator A5079681219 @default.
- W4283072036 date "2022-11-01" @default.
- W4283072036 modified "2023-10-17" @default.
- W4283072036 title "Targeting matrix metalloproteinases by E3 ubiquitin ligases as a way to regulate the tumor microenvironment for cancer therapy" @default.
- W4283072036 cites W1502344119 @default.
- W4283072036 cites W1549217097 @default.
- W4283072036 cites W1660470408 @default.
- W4283072036 cites W1707704257 @default.
- W4283072036 cites W1882059350 @default.
- W4283072036 cites W1964278005 @default.
- W4283072036 cites W1965205650 @default.
- W4283072036 cites W1965598402 @default.
- W4283072036 cites W1966980496 @default.
- W4283072036 cites W1971284419 @default.
- W4283072036 cites W1971462935 @default.
- W4283072036 cites W1978591675 @default.
- W4283072036 cites W1982030535 @default.
- W4283072036 cites W1982988030 @default.
- W4283072036 cites W1983614908 @default.
- W4283072036 cites W1984014002 @default.
- W4283072036 cites W1990706093 @default.
- W4283072036 cites W1995478441 @default.
- W4283072036 cites W1995708020 @default.
- W4283072036 cites W1999353132 @default.
- W4283072036 cites W2000285874 @default.
- W4283072036 cites W2003500892 @default.
- W4283072036 cites W2007691970 @default.
- W4283072036 cites W2011109079 @default.
- W4283072036 cites W2013464322 @default.
- W4283072036 cites W2014162746 @default.
- W4283072036 cites W2015116101 @default.
- W4283072036 cites W2015375238 @default.
- W4283072036 cites W2020235979 @default.
- W4283072036 cites W2027587678 @default.
- W4283072036 cites W2029187226 @default.
- W4283072036 cites W2031565845 @default.
- W4283072036 cites W2033341544 @default.
- W4283072036 cites W2033877970 @default.
- W4283072036 cites W2034483288 @default.
- W4283072036 cites W2035342682 @default.
- W4283072036 cites W2048313262 @default.
- W4283072036 cites W2048554743 @default.
- W4283072036 cites W2052550247 @default.
- W4283072036 cites W2053521300 @default.
- W4283072036 cites W2054455681 @default.
- W4283072036 cites W2055092042 @default.
- W4283072036 cites W2056290881 @default.
- W4283072036 cites W2059729323 @default.
- W4283072036 cites W2062353563 @default.
- W4283072036 cites W2063199747 @default.
- W4283072036 cites W2065340413 @default.
- W4283072036 cites W2066528969 @default.
- W4283072036 cites W2067576594 @default.
- W4283072036 cites W2072013301 @default.
- W4283072036 cites W2082985952 @default.
- W4283072036 cites W2084750055 @default.
- W4283072036 cites W2091998416 @default.
- W4283072036 cites W2101176202 @default.
- W4283072036 cites W2104148692 @default.
- W4283072036 cites W2112357436 @default.
- W4283072036 cites W2123322767 @default.
- W4283072036 cites W2132251735 @default.
- W4283072036 cites W2132523464 @default.
- W4283072036 cites W2138542236 @default.
- W4283072036 cites W2138888816 @default.
- W4283072036 cites W2145453023 @default.
- W4283072036 cites W2150251501 @default.
- W4283072036 cites W2150933596 @default.
- W4283072036 cites W2158705489 @default.
- W4283072036 cites W2220782796 @default.
- W4283072036 cites W2237983608 @default.
- W4283072036 cites W2252752229 @default.
- W4283072036 cites W2254625223 @default.
- W4283072036 cites W2255377321 @default.
- W4283072036 cites W2278703650 @default.
- W4283072036 cites W2312508287 @default.
- W4283072036 cites W2339282390 @default.
- W4283072036 cites W2339517282 @default.
- W4283072036 cites W2342305969 @default.
- W4283072036 cites W2416444310 @default.
- W4283072036 cites W2481563510 @default.
- W4283072036 cites W2504899658 @default.
- W4283072036 cites W2507916070 @default.
- W4283072036 cites W2509400142 @default.
- W4283072036 cites W2512899508 @default.
- W4283072036 cites W2513985818 @default.
- W4283072036 cites W2579718060 @default.
- W4283072036 cites W2587212963 @default.
- W4283072036 cites W2592710797 @default.
- W4283072036 cites W2598274320 @default.
- W4283072036 cites W2605078151 @default.