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• W4283072260 endingPage "110907" @default.
• W4283072260 startingPage "110907" @default.
• W4283072260 abstract "Caudal block helps relieve pain after sub-umbilical surgery in pediatric patients; however, the duration for which it exerts its analgesic effect is limited. The addition of certain adjuvant agents to local anesthetics (LAs) that are used to administer caudal block can prolong postoperative analgesia. Therefore, we aimed to compare the efficiencies and side effects of caudal adjuvants in the settings of pediatric lower abdominal and urological surgeries. A network meta-analysis (NMA). One hundred and twelve randomized controlled trials (RCTs) involving 6800 pediatric patients were included in the final analysis. Different adjuvant agents, namely clonidine, dexamethasone, dexmedetomidine, fentanyl, ketamine, magnesium, midazolam, morphine, neostigmine, and tramadol. The primary outcome was the duration of analgesia. The secondary outcomes included the requirement for additional analgesia, analgesic consumption, and postoperative complications. The effects and rankings were evaluated using NMA and the surface under the cumulative ranking curve scores, respectively. Neostigmine, dexmedetomidine, and dexamethasone were found to be the three most effective adjuvants that prolong the duration of analgesia for caudal block, and these adjuvants extended this duration by 8.9 h (95% confidence interval [CI], 7.1–10.7), 7.3 h (95% CI, 6.0–8.6), and 5.9 h (95% CI, 4.0–7.7), respectively. Caudal neostigmine was associated with an increase in the incidence of postoperative nausea and vomiting, whereas dexmedetomidine and dexamethasone showed no postoperative complications. This NMA provided evidence and suggested that dexmedetomidine and dexamethasone may be the most beneficial adjuvant pharmaceutics adding to LAs for caudal block in children. However, given the off-label status of caudal dexmedetomidine and dexamethasone, further high-quality RCTs are still warranted, especially to determine whether delayed neurological complications will occur." @default.
• W4283072260 created "2022-06-19" @default.
• W4283072260 creator A5011932006 @default.
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• W4283072260 creator A5028617095 @default.
• W4283072260 creator A5036159131 @default.
• W4283072260 creator A5049408675 @default.
• W4283072260 date "2022-10-01" @default.
• W4283072260 modified "2023-09-25" @default.
• W4283072260 title "Comparison of adjuvant pharmaceuticals for caudal block in pediatric lower abdominal and urological surgeries: A network meta-analysis" @default.
• W4283072260 cites W134548526 @default.
• W4283072260 cites W1500554236 @default.
• W4283072260 cites W1512480940 @default.
• W4283072260 cites W1529701853 @default.
• W4283072260 cites W1537972189 @default.
• W4283072260 cites W1604678961 @default.
• W4283072260 cites W1851466778 @default.
• W4283072260 cites W185775143 @default.
• W4283072260 cites W1913109589 @default.
• W4283072260 cites W1935178325 @default.
• W4283072260 cites W1939298252 @default.
• W4283072260 cites W1964956610 @default.
• W4283072260 cites W1965302235 @default.
• W4283072260 cites W1966540872 @default.
• W4283072260 cites W1967862123 @default.
• W4283072260 cites W1970222294 @default.
• W4283072260 cites W1972967759 @default.
• W4283072260 cites W1973825736 @default.
• W4283072260 cites W1976330014 @default.
• W4283072260 cites W1982518048 @default.
• W4283072260 cites W1985949691 @default.
• W4283072260 cites W1988514595 @default.
• W4283072260 cites W1990507564 @default.
• W4283072260 cites W1992885035 @default.
• W4283072260 cites W1993873525 @default.
• W4283072260 cites W2005501262 @default.
• W4283072260 cites W2008805389 @default.
• W4283072260 cites W2008988249 @default.
• W4283072260 cites W2018739740 @default.
• W4283072260 cites W2019281143 @default.
• W4283072260 cites W2019875891 @default.
• W4283072260 cites W2022868163 @default.
• W4283072260 cites W2026768731 @default.
• W4283072260 cites W2026801013 @default.
• W4283072260 cites W2030330586 @default.
• W4283072260 cites W2031853993 @default.
• W4283072260 cites W2034967012 @default.
• W4283072260 cites W2038465395 @default.
• W4283072260 cites W2038703024 @default.
• W4283072260 cites W2040740212 @default.
• W4283072260 cites W2041251004 @default.
• W4283072260 cites W2047968861 @default.
• W4283072260 cites W2049891044 @default.
• W4283072260 cites W2057097485 @default.
• W4283072260 cites W2061933350 @default.
• W4283072260 cites W2062284527 @default.
• W4283072260 cites W2064116139 @default.
• W4283072260 cites W2074484173 @default.
• W4283072260 cites W2078518565 @default.
• W4283072260 cites W2079527780 @default.
• W4283072260 cites W2083132715 @default.
• W4283072260 cites W2083551291 @default.
• W4283072260 cites W2085645028 @default.
• W4283072260 cites W2086353990 @default.
• W4283072260 cites W2091144355 @default.
• W4283072260 cites W2093789474 @default.
• W4283072260 cites W2100243067 @default.
• W4283072260 cites W2103325063 @default.
• W4283072260 cites W2105602787 @default.
• W4283072260 cites W2107272463 @default.
• W4283072260 cites W2118291309 @default.
• W4283072260 cites W2119360594 @default.
• W4283072260 cites W2141162363 @default.
• W4283072260 cites W2145082159 @default.
• W4283072260 cites W2150510807 @default.
• W4283072260 cites W2167508078 @default.
• W4283072260 cites W2170363811 @default.
• W4283072260 cites W2293087638 @default.
• W4283072260 cites W2316520842 @default.
• W4283072260 cites W2344167437 @default.
• W4283072260 cites W2412424887 @default.
• W4283072260 cites W2416828224 @default.
• W4283072260 cites W2485569989 @default.
• W4283072260 cites W2521563251 @default.
• W4283072260 cites W2524425435 @default.
• W4283072260 cites W2604185889 @default.
• W4283072260 cites W2607847717 @default.
• W4283072260 cites W2618239590 @default.
• W4283072260 cites W2624736328 @default.
• W4283072260 cites W2667124606 @default.
• W4283072260 cites W2736054093 @default.
• W4283072260 cites W2786678026 @default.
• W4283072260 cites W2787033326 @default.
• W4283072260 cites W2802006344 @default.
• W4283072260 cites W2817192291 @default.
• W4283072260 cites W2892281064 @default.

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