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- W4283073503 endingPage "104626" @default.
- W4283073503 startingPage "104626" @default.
- W4283073503 abstract "Lactic acid bacteria (LAB) influence multiple aspects of host brain function via the production of active metabolites in the gut, which is known as the pre/probiotic action. However, little is known about the biogenic effects of LAB on host brain function. Here, we reported that the Lactobacillus plantarum SBT2227 promoted sleep in Drosophila melanogaster. Administration of SBT2227 primarily increased the amount of sleep and decreased sleep latency at the beginning of night-time. The sleep-promoting effects of SBT2227 were independent of the existing gut flora. Furthermore, heat treatment or mechanical crushing of SBT2227 did not suppress the sleep-promoting effects, indicative of biogenic action. Transcriptome analysis and RNAi mini-screening for gut-derived peptide hormones revealed the requirement of neuropeptide F, a homolog of the mammalian neuropeptide Y, for the action of SBT2227. These biogenic effects of SBT2227 on the host sleep provide new insights into the interaction between the brain and gut bacteria." @default.
- W4283073503 created "2022-06-19" @default.
- W4283073503 creator A5017529117 @default.
- W4283073503 creator A5043859072 @default.
- W4283073503 creator A5052023233 @default.
- W4283073503 creator A5067796718 @default.
- W4283073503 date "2022-07-01" @default.
- W4283073503 modified "2023-09-26" @default.
- W4283073503 title "Biogenic action of Lactobacillus plantarum SBT2227 promotes sleep in Drosophila melanogaster" @default.
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