FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283074535> ?p ?o ?g. }

• W4283074535 endingPage "104055" @default.
• W4283074535 startingPage "104055" @default.
• W4283074535 abstract "Due to the presence of various phenolic compounds in D.sophia, this plant may have an inhibitory effect on α-Glc and ultimately diabetes control. Therefore, this work aims to scrutinize total phenolic, flavonoid contents, antioxidant capacity, and α-Glc inhibitory activity in aerial parts of methanolic D.sophia extract. The methanolic flower extracts were selected from among aerial parts for the experimental study of anti-diabetic effects by α-Glc inhibitory assays. The flower extracts were also studied by GC/MS to detect the compounds. The total phenolic and flavonoid contents were 21.38 ± 0.93 GAE/g and 96.2 ± 0.20 QE/g, respectively. The IC50 value of flower extract for α-Glc inhibition with mixed (Competitive/non-competitive) mode was found to be 20.34 ± 0.11 mg/ml. Furthermore, in-vivo studies showed that the blood glucose level reduced after consumption of flower extract compared to the control group. Twenty-one compounds were identified by GC/MS technique. These compounds were assessed for high docking scores against α-Glc in silico. Docking score calculations exhibited that the DES-α-Glc complex had a significantly higher binding energy (-6.13 Kcal/mol) than other compounds. The DES-α-Glc complex which displayed a higher docking energy value than the ACR was subjected to MDs studies. The findings of this study suggest that the flower extract of D.sophia can be used as a suitable additive in syrups or foods with anti-diabetic capacity." @default.
• W4283074535 created "2022-06-19" @default.
• W4283074535 creator A5011259094 @default.
• W4283074535 creator A5016847884 @default.
• W4283074535 creator A5023111251 @default.
• W4283074535 creator A5035269990 @default.
• W4283074535 creator A5035514926 @default.
• W4283074535 creator A5039363889 @default.
• W4283074535 date "2022-09-01" @default.
• W4283074535 modified "2023-10-18" @default.
• W4283074535 title "α-glucosidase inhibitory, antioxidant activity, and GC/MS analysis of Descurainia sophia methanolic extract: In vitro, in vivo, and in silico studies" @default.
• W4283074535 cites W1119486796 @default.
• W4283074535 cites W1970115948 @default.
• W4283074535 cites W1979509761 @default.
• W4283074535 cites W1988625184 @default.
• W4283074535 cites W1989582622 @default.
• W4283074535 cites W1993222740 @default.
• W4283074535 cites W2022971595 @default.
• W4283074535 cites W2024652253 @default.
• W4283074535 cites W2030843716 @default.
• W4283074535 cites W2037859272 @default.
• W4283074535 cites W2050045595 @default.
• W4283074535 cites W2060079863 @default.
• W4283074535 cites W2063731290 @default.
• W4283074535 cites W2072332315 @default.
• W4283074535 cites W2081131607 @default.
• W4283074535 cites W2085003543 @default.
• W4283074535 cites W2086472149 @default.
• W4283074535 cites W2089302393 @default.
• W4283074535 cites W2127062749 @default.
• W4283074535 cites W2134824140 @default.
• W4283074535 cites W2158919263 @default.
• W4283074535 cites W2469738507 @default.
• W4283074535 cites W2551567866 @default.
• W4283074535 cites W2584817868 @default.
• W4283074535 cites W2738105908 @default.
• W4283074535 cites W2772844214 @default.
• W4283074535 cites W2777510788 @default.
• W4283074535 cites W2790717534 @default.
• W4283074535 cites W2794690827 @default.
• W4283074535 cites W2797677845 @default.
• W4283074535 cites W2800250830 @default.
• W4283074535 cites W2803522209 @default.
• W4283074535 cites W2810920130 @default.
• W4283074535 cites W2883465725 @default.
• W4283074535 cites W2885064628 @default.
• W4283074535 cites W2894175307 @default.
• W4283074535 cites W2894357922 @default.
• W4283074535 cites W2896922334 @default.
• W4283074535 cites W2918882089 @default.
• W4283074535 cites W2933009095 @default.
• W4283074535 cites W2949806035 @default.
• W4283074535 cites W2969246006 @default.
• W4283074535 cites W2974127320 @default.
• W4283074535 cites W2990177226 @default.
• W4283074535 cites W2992127520 @default.
• W4283074535 cites W2997479242 @default.
• W4283074535 cites W3009822771 @default.
• W4283074535 cites W3026408804 @default.
• W4283074535 cites W3036402518 @default.
• W4283074535 cites W3088405594 @default.
• W4283074535 cites W3106181221 @default.
• W4283074535 cites W3170673291 @default.
• W4283074535 cites W3201729849 @default.
• W4283074535 cites W3209039719 @default.
• W4283074535 doi "https://doi.org/10.1016/j.arabjc.2022.104055" @default.
• W4283074535 hasPublicationYear "2022" @default.
• W4283074535 type Work @default.
• W4283074535 citedByCount "14" @default.
• W4283074535 countsByYear W42830745352022 @default.
• W4283074535 countsByYear W42830745352023 @default.
• W4283074535 crossrefType "journal-article" @default.
• W4283074535 hasAuthorship W4283074535A5011259094 @default.
• W4283074535 hasAuthorship W4283074535A5016847884 @default.
• W4283074535 hasAuthorship W4283074535A5023111251 @default.
• W4283074535 hasAuthorship W4283074535A5035269990 @default.
• W4283074535 hasAuthorship W4283074535A5035514926 @default.
• W4283074535 hasAuthorship W4283074535A5039363889 @default.
• W4283074535 hasBestOaLocation W42830745351 @default.
• W4283074535 hasConcept C104317684 @default.
• W4283074535 hasConcept C150903083 @default.
• W4283074535 hasConcept C159110408 @default.
• W4283074535 hasConcept C185592680 @default.
• W4283074535 hasConcept C202751555 @default.
• W4283074535 hasConcept C207001950 @default.
• W4283074535 hasConcept C2775905019 @default.
• W4283074535 hasConcept C2777752497 @default.
• W4283074535 hasConcept C2778004101 @default.
• W4283074535 hasConcept C2779054382 @default.
• W4283074535 hasConcept C41685203 @default.
• W4283074535 hasConcept C55493867 @default.
• W4283074535 hasConcept C556039675 @default.
• W4283074535 hasConcept C71240020 @default.
• W4283074535 hasConcept C71924100 @default.
• W4283074535 hasConcept C86803240 @default.
• W4283074535 hasConceptScore W4283074535C104317684 @default.
• W4283074535 hasConceptScore W4283074535C150903083 @default.
• W4283074535 hasConceptScore W4283074535C159110408 @default.

• next