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• W4283075158 abstract "<h3>Importance</h3> Limited studies have investigated the association between statin use and progression of arterial stiffness, a key player in the pathophysiology of cardiovascular disease. <h3>Objective</h3> To examine the association between statin use and progression of arterial stiffness in Chinese adults with high atherosclerotic risk measured by brachial-ankle pulse wave velocity (baPWV). <h3>Design, Setting, and Participants</h3> This retrospective cohort study enrolled 5105 adults with high atherosclerotic risk from the Kailuan General Hospital from 2010 to 2020. Data were analyzed from February 2021 to April 2022. <h3>Exposures</h3> Statin use information was retrieved from electronic medical records from 2010 to 2020, and statin users were those who have been prescribed any statin medications at least 6 months before baPWV measurements. Statin users were 1:1 matched with non–statin users by propensity score method. <h3>Main Outcomes and Measures</h3> Progression of baPWV was assessed using the absolute difference between baseline and follow-up baPWV, divided by the follow-up time in years. Multivariable linear regression models were used to estimate the association between statin use and arterial stiffness. <h3>Results</h3> Among 5105 adults with assessment of baPWV (mean [SD] age: 60.8 [9.7] years; 3842 [75.3%] men and 1263 [24.7%] women), 1310 statin users were matched with 1310 non–statin users (mean [SD] age, 63.2 [9.3] years). Compared with non–statin users, statin users were associated with significantly lower baPWV at baseline (difference: −33.6 cm/s; 95% CI, −62.1 to −5.1 cm/s). Among 1502 adults with repeated assessment of baPWV, 410 statin users were matched with 410 non–statin users (mean [SD] age, 62.9 [9.2] years). Compared with non–statin users, statin users had significantly slower progression of baPWV (difference, −23.3 cm/s per year; 95% CI, −40.6 to −6.0 cm/s per year) during a mean (SD) follow-up of 4.8 (2.7) years. A significantly slower progression of baPWV was observed in continuous statin users (difference, −24.2 cm/s per year; 95% CI, −42.2 to −6.3 cm/s per year) and high adherent users (difference, −39.7 cm/s per year; 95% CI, −66.9 to −12.4 cm/s per year), but not in discontinued users (difference, −17.3 cm/s per year; 95% CI, −52.4 to 17.8 cm/s per year) and low adherent users (difference, −17.9 cm/s per year; 95% CI, −36.5 to 0.7 cm/s per year), compared with non–statin users. <h3>Conclusions and Relevance</h3> In this cohort study, statin use was associated with slower progression of arterial stiffness in Chinese adults with high atherosclerotic risk." @default.
• W4283075158 created "2022-06-19" @default.
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• W4283075158 date "2022-06-17" @default.
• W4283075158 modified "2023-10-14" @default.
• W4283075158 title "Association Between Statin Use and Progression of Arterial Stiffness Among Adults With High Atherosclerotic Risk" @default.
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• W4283075158 doi "https://doi.org/10.1001/jamanetworkopen.2022.18323" @default.
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