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- W4283077751 abstract "Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes.Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. Children later diagnosed with type 1 diabetes and/or who tested positive for multiple islet autoantibodies (n = 43) were compared with control individuals (n = 79) who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis.No differences in the umbilical cord blood methylation patterns were observed between the cases and controls at a false discovery rate <0.05.Based on our results, differences between children who progress to type 1 diabetes and those who remain healthy throughout childhood are not yet present in the perinatal DNA methylome. However, we cannot exclude the possibility that such differences would be found in a larger dataset." @default.
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- W4283077751 date "2022-06-18" @default.
- W4283077751 modified "2023-10-17" @default.
- W4283077751 title "Umbilical cord blood DNA methylation in children who later develop type 1 diabetes" @default.
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- W4283077751 doi "https://doi.org/10.1007/s00125-022-05726-1" @default.
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