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• W4283080295 abstract "As the outermost barrier tissue of the body, the skin harbors a large number of innate lymphoid cells (ILCs) that help maintain local homeostasis in the face of changing environments. How skin-resident ILCs are regulated and function in local homeostatic maintenance is poorly understood. We here report the discovery of a cold-sensing neuron-initiated pathway that activates skin group 2 ILCs (ILC2s) to help maintain thermal homeostasis. In stearoyl-CoA desaturase 1 (SCD1) knockout mice whose skin is defective in heat maintenance, chronic cold stress induced excessive activation of CCR10 − CD81 + ST2 + skin ILC2s and associated inflammation. Mechanistically, stimulation of the cold-sensing receptor TRPM8 expressed in sensory neurons of the skin led to increased production of IL-18, which, in turn, activated skin ILC2s to promote thermogenesis. Our findings reveal a neuroimmune link that regulates activation of skin ILC2s to support thermal homeostasis and promotes skin inflammation after hyperactivation." @default.
• W4283080295 created "2022-06-19" @default.
• W4283080295 creator A5022105782 @default.
• W4283080295 creator A5028828648 @default.
• W4283080295 creator A5029215451 @default.
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• W4283080295 creator A5089138974 @default.
• W4283080295 creator A5090225509 @default.
• W4283080295 date "2022-06-24" @default.
• W4283080295 modified "2023-10-01" @default.
• W4283080295 title "Activation of CD81⁺skin ILC2s by cold-sensing TRPM8⁺neuron-derived signals maintains cutaneous thermal homeostasis" @default.
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